Microarray News and Research

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New test predicts how breast cancer patients respond to chemotherapy

Researchers at the Swiss Institute of Bioinformatics and the Swiss National Center of Competence in Research in Molecular Oncology in Lausanne have developed a new test to predict how breast cancer patients respond to chemotherapy, which could help change how treatment is delivered in the future.

3 Feb 2009

Chronic drinking causes more liver injury than acute or binge drinking

Alcohol consumption is known to cause liver damage. Yet the specifics of alcohol-induced liver injury can differ depending on the pattern of drinking.

3 Feb 2009

Roche NimbleGen microarray technology enables highest-resolution map of human genome copy number variation

Roche NimbleGen's CGH microarray platform was used to generate the highest-resolution map of human genome copy number variation.

23 Jan 2009

First genetic map of obesity

The first genetic map of obesity has been constructed using DNA microarray technology.

21 Jan 2009

Researchers find genes that fuse in cancer

Using new technologies that make it easier to sequence the human genome, researchers at the University of Michigan Comprehensive Cancer Center have identified a series of genes that become fused when their chromosomes trade places with each other.

12 Jan 2009

Gene abnormality found to predict childhood leukemia relapse

Scientists have identified mutations in a gene that predict a high likelihood of relapse in children with acute lymphoblastic leukemia (ALL).

8 Jan 2009

Gene mutations found to predict acute lymphoblastic leukemia relapse

Scientists have identified mutations in a gene that predict a high likelihood of relapse in children with acute lymphoblastic leukemia (ALL).

7 Jan 2009

Metadherin gene linked to metastasis of breast cancer

A team of researchers at Princeton University and The Cancer Institute of New Jersey has identified a long-sought gene that is fatefully switched on in 30 to 40 percent of all breast cancer patients, spreading the disease, resisting traditional chemotherapies and eventually leading to death.

5 Jan 2009

Inherited factors play key role in breast cancer

New research in mice and five independent collections of human breast tumors has enabled National Cancer Institute (NCI) scientists to confirm that genes for factors contributing to susceptibility for breast cancer metastasis can be inherited.

5 Jan 2009

Archived blood from infant heel stick tests could lead to discoveries about diseases that have roots in perinatal period

Van Andel Institute (VAI) researchers are the first to apply a new technology to measure on a large scale the presence of genes in blood spots - the blood drawn from newborn infants to screen for health-threatening conditions.

16 Dec 2008

Gene subnetworks provide new prognostic markers for breast cancer

The metastasis or spread of breast cancer to other tissues in the body can be predicted more accurately by examining subnetworks of gene expression patterns in a patient's tumor, than by conventional gene expression microarrays, according to a presentation at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco.

15 Dec 2008

GUMC researchers find gene inactivated in two aggressive cancers

Researchers at Georgetown University Medical Center have found a gene they say is inactivated in two aggressive cancers - malignant melanoma, a form of skin cancer, and glioblastoma multiforme, a lethal brain tumor.

15 Dec 2008

A new approach improves prioritization of disease-associated SNPs

The more often a gene is differentially expressed, the more likely it is to contain disease-associated DNA variants.

5 Dec 2008

New technique provides closer look at DNA and mRNA

In a study in the advance online edition of Nature Structural and Molecular Biology, researchers from Albert Einstein College of Medicine describe a technique for looking more precisely at a fundamental step of a cell's life - a gene, DNA, being read into a message, mRNA.

3 Dec 2008

Researchers identify a potentially universal mechanism of aging

Like our current financial crisis, the aging process might also be a product excessive deregulation.

26 Nov 2008

Roche NimbleGen launches microarrays for analysis of DNA copy number variation

Roche NimbleGen, Inc. has launched NimbleGen Comparative Genomic Hybridization (CGH) microarrays in a 12x135K format for analysis of DNA copy number variation.

19 Nov 2008

Microarray analysis improves prenatal diagnosis

A "chip" or array that can quickly detect disorders such as Down syndrome or other diseases associated with chromosomal abnormalities proved an effective tool in prenatal diagnosis in a series of 300 cases at Baylor College of Medicine, said researchers in a report that appears in the current issue of the journal Prenatal Diagnosis.

17 Nov 2008

First comprehensive genetic blueprint of a forming mammalian organ

Part of an international consortium sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a research team led by Cincinnati Children's Hospital Medical Center reports the creation of a detailed genome-based atlas for understanding healthy and abnormal kidney development and disease.

11 Nov 2008

New therapeutic target for inflammatory disorders

Researchers at Hospital for Special Surgery have identified a potential new therapeutic target that could be used to treat inflammatory disorders, such as rheumatoid arthritis.

6 Nov 2008

Scientists map molecular regulation of fat-cell genetics

A research team led by Mitchell Lazar, MD, PhD, Director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania School of Medicine, has used state-of-the-art genetic technology to map thousands of positions where a molecular "master regulator" of fat-cell biology is nestled in DNA to control genes in these cells.

5 Nov 2008