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Researchers to apply smartphone apps to manage anxiety, depression in breast cancer patients

Home sensors to monitor cancer patients' pain. A smartphone app to manage breast cancer patients' anxiety and depression. And $12 million in new grant funding to pay for even more health care advances, earned from just a $2 million initial investment.

23 Apr 2021

SARS-CoV-2-associated ssRNAs trigger inflammation and immunity via toll-like receptors

Severe COVID-19 causes sepsis-like manifestations, intense lung injury, and multi-organ failure, all associated with the overproduction of pro-inflammatory cytokines. This "cytokine storm" directly correlates with poor prognosis in this subgroup of patients.

21 Apr 2021

Study provides the first extensive genetic and phenotype landscape of peripartum cardiomyopathy

Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), a rare condition characterized by weakness of the heart muscle that begins sometime during the final month of pregnancy through five months after delivery.

20 Apr 2021

Study sheds new light on the ability of pancreatic cancer cells to metastasize

With an overall survival rate of 9% for those diagnosed, pancreatic cancer remains exceedingly difficult to treat. However, the patient's primary tumor typically isn't what leads to death - it is the cancer's ability to evade detection and metastasize to other organs.

19 Apr 2021

Researchers identify two distinct phenotypes of COVID-19-associated ARDS

Approximately one in four patients hospitalized for the acute respiratory distress syndrome (ARDS) associated with severe COVID-19 infections may have a distinct phenotype (disease presentation) or biochemical profile associated with organ dysfunction, blood-clotting abnormalities and greater risk of death than patients with other, seemingly similar forms of the disease, researchers at Massachusetts General Hospital have found.

15 Apr 2021

Early exposure to air pollutant may contribute to non-atopic childhood asthma

Asthma afflicts more than 300 million people worldwide. The most severe manifestation, known as non-Th2, or non-atopic childhood asthma, represents the majority of the cases, greater than 85%, particularly in low-income countries, according to Hyunok Choi, an associate professor at the Lehigh University College of Health.

15 Apr 2021

Phase II of Singapore's National Precision Medicine strategy to begin in April 2021

Precision medicine is part of Singapore's Research, Innovation and Enterprise (RIE) 2025 strategic goal to transform and protect the health of every Singaporean.

7 Apr 2021

Finding ways to reverse a genetic cause of poor stress responses in mice

Everyone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well as others.

7 Apr 2021

UCI receives $4.2 million grant to study sporadic inclusion body myositis affecting aging adults

The National Institute of Arthritis and Musculoskeletal and Skin Diseases has awarded UCI a 5-year, $4.2 million grant to study sporadic inclusion body myositis (sIBM), which affects aging adults causing asymmetric muscle weakness and severe disability. The disease is currently untreatable and poorly understood.

6 Apr 2021

Researchers evaluate new drug for spinal muscular atrophy in a broader spectrum of patients

The rarity of spinal muscular atrophy (SMA) means that promising new treatments may be tested in only a limited spectrum of patients before approval. Investigators evaluated a newly approved drug, onasemnogene abeparvovec, in a broader spectrum of patients in order to obtain expanded data on its side effects profile.

6 Apr 2021

Study identifies three clinical COVID-19 phenotypes

In a new study, researchers identify three clinical COVID-19 phenotypes, reflecting patient populations with different comorbidities, complications and clinical outcomes.

3 Apr 2021

Proper choice of control group nullifies most observed genetic markers for severe COVID-19, study suggests

A new study deals with the genetic contribution to severe disease following infection with this virus, showing that the association of severity with specific human genes described in an earlier study is not obvious.

2 Apr 2021

Scientists review current knowledge of the role of calcium-sensing receptor in immune cells

In a new publication from Cardiovascular Innovations and Applications, Wenxiu Liu, Yutong Guo, Yue Liu, Jiaxing Sun and Xinhua Yin from The First Affiliated Hospital of Harbin Medical University, Heilongjiang, China consider calcium-sensing receptors of immune cells and diseases.

29 Mar 2021

Study identifies key features in SARS-CoV-2 genome essential for replication in respiratory cells

Researchers at the Institute of Medical Virology, the University of Zurich in Switzerland, have identified features in the SARS-CoV-2 genome that are important for human respiratory cell growth.

29 Mar 2021

Persistent impact on smell and taste in COVID-19 patients one year later

The presentation of the infection ranges from asymptomatic, through dry cough with fever, anosmia/dysgeusia, to shortness of breath with severe acute respiratory distress syndrome (ARDS). A new preprint research paper posted to the medRxiv* server reports on the clinical progression of anosmia and dysgeusia, in particular, one year after the infection.

29 Mar 2021

Research could lead to a personalized approach for treating sickle cell disease

Sickle cell disease is the most prevalent inherited blood disorder in the world, affecting 70,000 to 100,000 Americans. However, it is considered an orphan disease, meaning it impacts less than 200,000 people nationally, and is therefore underrepresented in therapeutic research.

24 Mar 2021

Pangolin coronavirus sheds light on UK SARS-CoV-2 variant's evolutionary trajectory

Researchers at the Division of Infection and Immunity, University College London, UK, have provided key insights into the characteristics of the B.1.1.7 (or UK) variant of SARS-CoV-2.

24 Mar 2021

Cellular senescence of cancer-associated fibroblasts play a key role in peritoneal dissemination

Through an analysis of cellular components (cell fractions) from malignant ascites (fluid buildup in the abdomen caused by gastric cancer), a research collaboration based in Kumamoto University (Japan) has demonstrated that cellular senescence of cancer-associated fibroblasts (CAFs) play an important role in the peritoneal dissemination of gastric cancer foci (cells different from surrounding cells).

23 Mar 2021

Hidden genetic defects can lead to all kinds of serious illnesses

For the first time researchers from Hebrew University of Jerusalem, Radboudumc, Maastricht UMC+ and international colleagues have gained insight into the "hidden genetic defects" of the general European population.

19 Mar 2021

A complete genetic and clinical analysis of individuals with SCN2A-related disorders

Researchers from Children's Hospital of Philadelphia affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) have compiled a complete genetic and clinical analysis of more than 400 individuals with SCN2A-related disorder, which has been linked to a variety of neurodevelopmental disorders, including epilepsy and autism.

17 Mar 2021

Phenotype News and Research

Researchers to apply smartphone apps to manage anxiety, depression in breast cancer patients

SARS-CoV-2-associated ssRNAs trigger inflammation and immunity via toll-like receptors

Study provides the first extensive genetic and phenotype landscape of peripartum cardiomyopathy

Study sheds new light on the ability of pancreatic cancer cells to metastasize

Researchers identify two distinct phenotypes of COVID-19-associated ARDS

Early exposure to air pollutant may contribute to non-atopic childhood asthma

Phase II of Singapore's National Precision Medicine strategy to begin in April 2021

Finding ways to reverse a genetic cause of poor stress responses in mice

UCI receives $4.2 million grant to study sporadic inclusion body myositis affecting aging adults

Researchers evaluate new drug for spinal muscular atrophy in a broader spectrum of patients

Study identifies three clinical COVID-19 phenotypes

Proper choice of control group nullifies most observed genetic markers for severe COVID-19, study suggests

Scientists review current knowledge of the role of calcium-sensing receptor in immune cells

Study identifies key features in SARS-CoV-2 genome essential for replication in respiratory cells

Persistent impact on smell and taste in COVID-19 patients one year later

Research could lead to a personalized approach for treating sickle cell disease

Pangolin coronavirus sheds light on UK SARS-CoV-2 variant's evolutionary trajectory

Cellular senescence of cancer-associated fibroblasts play a key role in peritoneal dissemination

Hidden genetic defects can lead to all kinds of serious illnesses

A complete genetic and clinical analysis of individuals with SCN2A-related disorders

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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