Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Validation of cardiovascular risk scores in a liver transplant population

Two methods of assessing a patient's risk of cardiovascular events - SCORE and PROCAM - proved more valuable for liver transplant recipients than an alternative method, according to a new study.

7 Mar 2006

Researchers transplant insulin-producing neonatal porcine islet cells into monkeys

A team of researchers from the University of Alberta, the Yerkes National Primate Research Center of Emory University and the Emory Transplant Center has successfully transplanted insulin-producing neonatal porcine islet cells into monkeys, a procedure the researchers say represents a promising intermediate solution to the critical supply problem in clinical islet cell transplantation.

27 Feb 2006

Herbal supplements and plastic surgery don't mix well

Natural herbal supplements are supposed to help boost our immune systems, give us more energy and make us generally healthier.

14 Feb 2006

Sirolimus reduces risk of cancer in kidney transplant patients

A new study published in this month's issue of the Journal of the American Society of Nephrology shows that the risk of cancer in kidney transplant recipients was reduced by more than 50% at five years post transplantation in those patients who were treated with sirolimus following withdrawal of cyclosporine at three months.

13 Feb 2006

Cyclosporine suppresses hepatitis C virus and increases the chance of a sustained virological response after liver transplantation

Liver transplant patients with hepatitis C virus (HCV) achieved significantly better long-term viral response when taking the immunosuppressive agent Cyclosporine along with interferon-ribavirin combination therapy. Cyclosporine also showed efficacy against Hepatitis C virus in vitro.

5 Jan 2006

French woman has worlds' first face transplant

The operation apparently lasted several hours where tissues, muscles, arteries and veins were taken from a brain-dead donor and attached to the patient's lower face.

30 Nov 2005

Ischemic brain injury - another promising avenue for stem cell therapy

Adult stem cell therapy quickly and significantly improves recovery of motor function in an animal model for the ischemic brain injury that occurs in about 10 percent of babies with cerebral palsy, researchers report.

4 Oct 2005

People who receive a kidney transplant are nearly four times more likely to develop melanoma

...a rare but deadly form of skin cancer, according to a study led by Christopher Hollenbeak, Ph.D., associate professor, Departments of Surgery and Health Evaluation Sciences, Penn State College of Medicine, Penn State Milton S. Hershey Medical Center.

28 Sep 2005

Transplanted insulin-producing cells survive better when the activation of NKT cells are blocked

Scientists in Japan have found a way to improve on a promising diabetes treatment. In the October 3 issue of The Journal of Experimental Medicine, Masaru Taniguchi and colleagues report that transplanted insulin-producing cells survive better when the activation of a specific type of immune cell is blocked.

27 Sep 2005

People who receive a kidney transplant are nearly four times more likely to develop melanoma

...a rare but deadly form of skin cancer, according to a study in the November 1, 2005 issue of Cancer, a peer-reviewed journal of the American Cancer Society.

26 Sep 2005

Dental problems caused by radiation, chemotherapy should be treated before a child undergoes immunosuppression as part of bone marrow transplantation therapy

Many children who undergo bone marrow transplantation (BMT) as part of cancer treatment already have dental abnormalities that leave them vulnerable to potentially life-threatening bacterial infections, according to investigators at St. Jude Children's Research Hospital. A report on this study appears in the prepublication online edition of Bone Marrow Transplantation.

29 Aug 2005

SPF may not be enough to protect against skin cancer

Immune protection factor (IPF) in sunscreens and its relation to sun protection factor (SPF) is essential in determining skin cancer prevention ability, researchers found.

29 Aug 2005

Stem cell therapy can be used effectively to treat heart attacks, or myocardial infarction, in pigs

In just two months, stem cells harvested from another pig's bone marrow and injected into the animal's damaged heart restored heart function and repaired damaged heart muscle by 50 percent to 75 percent.

25 Jul 2005

Minimally invasive colorectal surgery may have a less pronounced inflammatory response

Minimally invasive colorectal surgery may have a less pronounced inflammatory response and less of a suppressing effect on the immune system than conventional surgery, resulting in a possible reduction in post-operative complications, according to a study in the July issue of Archives of Surgery.

19 Jul 2005

Researchers clarifiy role of Notch protein in T-cell development

Researchers at the University of Pennsylvania School of Medicine have recently clarified the role of the Notch protein in T-cell development. T cells are required for many aspects of immunity, including fighting viral infections, providing cancer surveillance, and regulating multiple aspects of the immune response.

6 Jul 2005

Breast cancer chemotherapy regimen associated with life-threatening complications

The chemotherapy regimen of doxorubicin plus docetaxel, used to treat breast cancer in a clinical trial, was associated with an increased risk of serious complications, resulting in the premature termination of the trial, according to a study in the May 18 issue of JAMA.

17 May 2005

High levels of immunosuppressant may lead to tumor recurrence

A new study on the incidence of liver cancer after transplant found that high levels of the immunosuppressant cyclosporine favored tumor recurrence and identified blood levels of the drug that should not be exceeded. Lower levels of cyclosporine levels did not affect rejection rates.

22 Apr 2005

Cyclosporine inhalation solution (CyIS) significantly improves long-term survival in lung-transplant patients

Data presented for the first time at the 25th Annual Meeting and Scientific Session of the International Society for Heart and Lung Transplantation (ISHLT) show that cyclosporine inhalation solution (CyIS) significantly improves long-term survival in lung-transplant patients compared to placebo.

10 Apr 2005

Donor age has no affect on long-term liver transplant survival

A new study on the effect of donor age on survival and recurrence of hepatitis C after liver transplantation found that it influenced short-term survival, but had no long-term effect.

22 Mar 2005

Antiretroviral therapy may prevent some cancers in people with HIV

In people infected with human immunodeficiency virus (HIV), highly active antiretroviral therapy (HAART) may prevent most excess cases of Kaposi sarcoma and non-Hodgkin lymphoma, according to a new study in the March 16 issue of the Journal of the National Cancer Institute.

15 Mar 2005

Immunosuppression News and Research

Further Reading

Validation of cardiovascular risk scores in a liver transplant population

Researchers transplant insulin-producing neonatal porcine islet cells into monkeys

Herbal supplements and plastic surgery don't mix well

Sirolimus reduces risk of cancer in kidney transplant patients

Cyclosporine suppresses hepatitis C virus and increases the chance of a sustained virological response after liver transplantation

French woman has worlds' first face transplant

Ischemic brain injury - another promising avenue for stem cell therapy

People who receive a kidney transplant are nearly four times more likely to develop melanoma

Transplanted insulin-producing cells survive better when the activation of NKT cells are blocked

People who receive a kidney transplant are nearly four times more likely to develop melanoma

Dental problems caused by radiation, chemotherapy should be treated before a child undergoes immunosuppression as part of bone marrow transplantation therapy

SPF may not be enough to protect against skin cancer

Stem cell therapy can be used effectively to treat heart attacks, or myocardial infarction, in pigs

Minimally invasive colorectal surgery may have a less pronounced inflammatory response

Researchers clarifiy role of Notch protein in T-cell development

Breast cancer chemotherapy regimen associated with life-threatening complications

High levels of immunosuppressant may lead to tumor recurrence

Cyclosporine inhalation solution (CyIS) significantly improves long-term survival in lung-transplant patients

Donor age has no affect on long-term liver transplant survival

Antiretroviral therapy may prevent some cancers in people with HIV

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