Chromosome 4 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 4, one copy inherited from each parent, form one of the pairs. Chromosome 4 spans more than 191 million DNA building blocks (base pairs) and represents more than 6 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 4 likely contains between 1,300 and 1,600 genes.

Genes on chromosome 4 are among the estimated 20,000 to 25,000 total genes in the human genome.

Y chromosome loss in men can lead to deadly heart failure, research shows

The loss of the male sex chromosome as many men age causes the heart muscle to scar and can lead to deadly heart failure, new research from the University of Virginia School of Medicine shows.

14 Jul 2022

Study describes biochemical pathway that leads to inflammation characteristic of autoimmune diseases

Mitochondria are self-contained organelles (they possess their own mini-chromosome and DNA) residing within cells and are charged with the job of generating the chemical energy needed to fuel functions essential to life and well-being.

13 Jul 2022

New underlying cause of Wiskott-Aldrich syndrome discovered

Researchers at the Salk Institute and King Abdullah University of Science and Technology (KAUST) in Saudi Arabia have discovered a new underlying cause of Wiskott-Aldrich syndrome, a rare genetic disease that leads to bleeding and immune deficiencies in babies.

13 Jul 2022

Genetically-enhanced biocontrols can help eradicate invasive alien mammals

Invasive alien mammals can have catastrophic impacts on native flora and fauna, causing species extinctions and driving profound environmental change.

8 Jul 2022

Study identifies chromosomal abnormalities associated with relapse in frequent subtype of childhood B-ALL

An international research team coordinated by Dr. Oscar Molina and Dr. Pablo Menéndez, from the Josep Carreras Leukaemia Research Institute, identifies chromosomal abnormalities associated to relapse in a frequent subset of B-cell Acute Lymphoblastic Leukemia (B-ALL), a severe condition affecting especially children.

7 Jul 2022

The role of myostatin in female fertility

A new study discusses some of the key functions of myostatin in female reproductive health and disease.

6 Jul 2022

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

The Damon Runyon Cancer Research Foundation has named five new Damon Runyon Clinical Investigators.

6 Jul 2022

Biologists shed light on the evolution and consequences of selfish genetic elements

The human genome is littered with "selfish genetic elements," which do not seem to benefit their hosts, but instead seek only to propagate themselves.

6 Jul 2022

"Selfish chromosomes" explain why most human embryos die very early on, study suggests

New research by a scientist at the Milner Center for Evolution at the University of Bath suggests that "selfish chromosomes" explain why most human embryos die very early on. The study, published in PLoS, Biology, explaining why fish embryos are fine but sadly humans' embryos often don't survive, has implications for the treatment of infertility.

6 Jul 2022

New, safer CRISPR approach may help correct genetic defects in the future

Curing debilitating genetic diseases is one of the great challenges of modern medicine. During the past decade, development of CRISPR technologies and advancements in genetics research brought new hope for patients and their families, although the safety of these new methods is still of significant concern.

1 Jul 2022

NUS researchers discover a new way to interpret unsolved Mendelian diseases

The development of an embryo is a well-orchestrated string of processes, ensuring correct formation and positioning of vital organs of the growing organism.

29 Jun 2022

Duke researchers identify role for key gene in developmental disability syndrome

A single gene that was previously found to be the driving force in a rare syndrome linked to epilepsy, autism and developmental disability has been identified as a linchpin in the formation of healthy neurons.

28 Jun 2022

Study identifies critical genes and biological pathways related to COVID-19 myocarditis

Scientists from China have recently deciphered the genetic network and biological mechanisms associated with COVID-19 myocarditis using bioinformatic methods.

28 Jun 2022

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

Lamivudine, a commonly-used antiretroviral drug for treating HIV, improves cognition in a mouse model of Down syndrome, according to the findings of a joint new study by researchers at the Centre for Genomic Regulation (CRG) and the IrsiCaixa AIDS Research Institute, a center jointly promoted by the "la Caixa" Foundation and the Department of Health of the Generalitat de Catalunya.

28 Jun 2022

Recombinant SARS-CoV-2 harboring double reporters for COVID-19 surveillance

In a recent article posted to the bioRxiv* preprint server, researchers at Texas Biomedical Research Institute, Georgia State University, and the University of Alabama at Birmingham developed a bireporter-expressing recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) for tracking SARS-CoV-2 infection.

27 Jun 2022

Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

Results of a study of molecular tumor profiling in young patients revealed a high rate of genetic alterations with potential for impacting clinical care, including clarifying diagnoses and treatment with matched, precision cancer drugs.

23 Jun 2022

Scientists publish a robust framework to analyze chromosomal instability in human cancers

Scientists have found a way to identify and interpret 'signatures' that reveal the complex genetic causes of some of the deadliest cancers – which often have a survival rate of less than 10%.

15 Jun 2022

Study sheds light on inhibition of awn elongation in sorghum

Over the years, the domestication of grasses like wheat, rice, barley, and sorghum for consumption has resulted in certain modifications to their morphology. One such modification is the partial or complete elimination of the 'awns', which are the bristle- or needle-like appendages extending from the tip of the lemma in grass spikelets.

15 Jun 2022

Chromosome organization affects evolution of DNA in archaea

The structure of how DNA is stored in archaea makes a significant difference to how quickly it evolves, according to a new study by Indiana University researchers.

14 Jun 2022

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Researchers described potential mechanisms of coronaviruses that could lead to DNA damage and the potential link between SARS-CoV-2 activity and such mechanisms.

14 Jun 2022

Chromosome 4 News and Research

Further Reading

Y chromosome loss in men can lead to deadly heart failure, research shows

Study describes biochemical pathway that leads to inflammation characteristic of autoimmune diseases

New underlying cause of Wiskott-Aldrich syndrome discovered

Genetically-enhanced biocontrols can help eradicate invasive alien mammals

Study identifies chromosomal abnormalities associated with relapse in frequent subtype of childhood B-ALL

The role of myostatin in female fertility

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

Biologists shed light on the evolution and consequences of selfish genetic elements

"Selfish chromosomes" explain why most human embryos die very early on, study suggests

New, safer CRISPR approach may help correct genetic defects in the future

NUS researchers discover a new way to interpret unsolved Mendelian diseases

Duke researchers identify role for key gene in developmental disability syndrome

Study identifies critical genes and biological pathways related to COVID-19 myocarditis

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

Recombinant SARS-CoV-2 harboring double reporters for COVID-19 surveillance

Molecular tumor profiling in pediatric cancer patients significantly impacts clinical care

Scientists publish a robust framework to analyze chromosomal instability in human cancers

Study sheds light on inhibition of awn elongation in sorghum

Chromosome organization affects evolution of DNA in archaea

The potential mechanisms of SARS-CoV-2 to induce DNA damage

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