Disease Modeling News and Research

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Hybrid approach reveals details about genes involved in Meier-Gorlin syndrome

Meier-Gorlin syndrome, or MGS, is a rare genetic developmental disorder that causes dwarfism, small ears, a small brain, missing patella and other skeletal abnormalities. In severe cases, MGS results in miscarriages and stillbirths.

14 Dec 2020

Researchers develop analytical model to gauge SARS-CoV-2 transmission dynamics in schools

Research highlight the risk of virus spread in schools in the Netherlands. Since most schools across countries have resumed in-person or face-to-face classes, knowing the virus's risk and transmission dynamics in this context is crucial.

9 Dec 2020

Synthetic biology and machine-learning can speed up maturation of lab-grown organ

Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine-learning algorithm to create human liver organoids with blood- and bile-handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life.

8 Dec 2020

Study describes the early evolution of oral poliovirus vaccine

While the world reels from the spread of SARS-CoV2, the new coronavirus behind COVID-19, a much older and previously feared scourge--poliovirus--is close to being completely eradicated.

19 Nov 2020

Global collaboration provides a COVID-19 disease map

A collaboration of researchers from 120 different institutes across 30 countries including France, Germany, Australia, Japan, USA, India, Turkey, Brazil, and Canada initiated an effort to develop a COVID-19 Disease Map - a collection of computational models and diagrams of molecular mechanisms implicated in COVID-19.

2 Nov 2020

Scientists develop new model of coronavirus diffusion through a community

The coronavirus doesn't spread uniformly through a community.But in the world of disease modeling, many projections take a high-level approach to a geographic area, like a county or state, and forecast based on a general idea that a virus will take root and spread at an equal rate until it reaches its peak of infection.

30 Oct 2020

Tabba Heart Institute and IHME partner to improve cardiovascular health in Pakistan

Tabba Heart Institute and the Institute for Health Metrics and Evaluation at the University of Washington's School of Medicine are partnering to improve public knowledge and inform policymakers of cardiovascular health in Pakistan by collecting and sharing data, leveraging their expertise in health metrics sciences to provide more accurate estimates of the national and provincial burden of cardiovascular diseases in Pakistan.

28 Oct 2020

Adult stem cell-based lung organoid models emulate host immune response in fatal COVID-19

Recently, a team of researchers from the University of California San Diego and The Scripps Research Institute, CA, USA, showed that an integrated stem cell-based disease modeling and computational approach is crucial for simulating the host immune response in fatal COVID-19 patients.

19 Oct 2020

NIH provides $9.3 million grant to create new Center for Precision Animal Modeling at UAB

A new Center for Precision Animal Modeling, or C-PAM, has been created at the University of Alabama at Birmingham, supported by a five-year, $9.3 million grant from the National Institutes of Health's Office of Research Infrastructure Programs.

9 Oct 2020

Viral loads peak before symptom onset in COVID-19

By reviewing published literature on viral loads and viral shedding, researchers found that viral loads for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)peak before symptoms are seen. This has substantial implications for prevention strategies.

5 Oct 2020

NIH awards grants for using bioengineered models to improve clinical trial design

Clinical Trials on a Chip researchers plan to build and test common and rare disease models to help improve the clinical trial process.

30 Sep 2020

Gruthan Bioscience to develop new class of cholesterol-lowering drugs

Gruthan Bioscience, LLC, a Medical University of South Carolina startup based in Charleston, South Carolina, received a Small Business technology Transfer (STTR) award from the National Heart, Blood and Lung Institute in August to take the next step in developing a novel class of cholesterol-lowering drugs to treat familial hypercholesterolemia.

24 Sep 2020

Curi Bio Announces Mantarray™ Platform for Analysis of 3D Engineered Muscle Tissues for Discovery of New Therapeutics

Curi Bio today announced the Mantarray™ platform for human-relevant 3D engineered muscle tissue (EMT) analysis.

From Curi Bio 16 Sep 2020

Balancing COVID-19 risk with educational benefits in school reopening decisions

Now a new study by researchers at the Institute for Disease Modeling and published on the preprint server medRxiv* in September 2020 focuses on modeling the potential risk of COVID-19 for school students and staff if schools are re-opened in a range of scenarios. This could guide further research on the health and educational outcomes of school reopenings.

14 Sep 2020

New EU research project seeks to kickstart the development of "Organoid Cell Atlas"

HCA|Organoid is a new EU research project that combines single-cell profiling and organoid technology to validate organoids as faithful models of human biology.

31 Aug 2020

Inconsistent implementation of COVID-19 control has dire consequences

Researchers in the United States have conducted a study highlighting the potential unintended consequences of implementing coronavirus disease 2019 (COVID-19) control policies in an inconsistent, patchy manner.

25 Aug 2020

Researchers achieve bleeding-free anti-coagulation with synthetic inhibitor

Patients who suffer from thrombosis, pulmonary embolism or stroke are usually put on drugs that help their blood flow more smoothly through their body.

4 Aug 2020

Scientists develop human lung organoids to study SARS-CoV-2 infection

Now, a new study published on the preprint server bioRxiv in July 2020 reports the development of a human distal lung culture system that can be functionally tested. This will help not only to understand how this infection produces disease but also to test the proliferative capacity of the stem cells in this part of the body.

30 Jul 2020

NanoSurface Biomedical is now Curi Bio

NanoSurface Biomedical, a leading developer of human stem cell-based biotechnology products, today announced a comprehensive rebrand, including a change of the company’s name to Curi Bio.

From Curi Bio 15 Jul 2020

Fred Hutch joins new clinical trials network to fight COVID-19

Fred Hutchinson Cancer Research Center has been named the coordinating center for vaccine clinical trials of the COVID-19 Prevention Network.

8 Jul 2020