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New signaling mechanism implicated in the development of ventricular fibrillation

A study led by Guadalupe Sabio and José Jalife at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid has identified a new signaling mechanism implicated in the development of ventricular fibrillation, a type of arrhythmia, or irregular heartbeat.

27 Nov 2023

The future of functional foods: Leveraging Dendrobium officinale for optimal gut health and disease prevention

The structure, extraction, health benefits, and mechanisms of Dendrobium officinale polysaccharides (DOPs).

27 Nov 2023

Mendelian randomization reveals a causal relationship between diabetes mellitus and pancreatic cancer

Announcing a new article publication for BIO Integration journal. This study investigates the association between diabetes mellitus and susceptibility to pancreatic cancer by using Mendelian randomization (MR) methods and an extensive human genome-wide association study (GWAS) dataset.

23 Nov 2023

Microautophagy plays crucial role in lysosome repair, promoting healthy aging

To age or not to age! How does aging affect organisms on a cellular level? What mechanisms help cells survive self-inflicted or external harm? It is known that lysosomes-;critically important cellular structures-;are crucial for digesting damaged cellular components and pathogens, and maintain stability within cells and tissues.

21 Nov 2023

Bacteria fight phages with RNA-based immune defense

There's no organism on earth that lives free of threat-;including bacteria. Predatory viruses known as phages are among their most dire foes, infiltrating their cells to replicate and take over.

15 Nov 2023

Charting the future of IBD treatment: From immune modulators to microRNA therapies

In a recent study published in the journal eGastroenterology, researchers delved into the latest therapeutic strategies for managing inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The paper discusses emerging treatments ranging from immune-modulating drugs and biologics to novel approaches like microRNA upregulators and stem cell therapies, highlighting the need for precision medicine in IBD care.

8 Nov 2023

Proteomic study pinpoints potential biomarkers for long-COVID diagnosis and persistent health impacts

A two-year longitudinal study highlights proteomic changes in long-COVID patients, revealing potential biomarkers for diagnosis and shedding light on the persistent physiological challenges faced by survivors.

7 Nov 2023

Yabing Chen receives NIH grants to advance vascular disease research

Yabing Chen, Ph.D., has been awarded two National Institutes of Health grants totaling more than $5 million to further her research into vascular diseases ranging from hardening of the arteries to dementia.

6 Nov 2023

New mechanism discovered for aspirin's cancer-fighting properties

LMU researchers have identified a signaling pathway by which aspirin can inhibit colorectal cancer.

2 Nov 2023

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Dendritic cells play a key role in the mammalian immune system. These cells are present throughout the human body and are known to capture foreign bodies, i.e., antigens, using extendable "arms" called dendrites.

30 Oct 2023

Study shows phages can promote mammalian cellular growth and survival

Bacteriophages, also called phages, are viruses that infect and kill bacteria, their natural hosts. But from a macromolecular viewpoint, phages can be viewed as nutritionally enriched packets of nucleotides wrapped in an amino acid shell.

26 Oct 2023

Newly identified small molecule can suppress growth of breast and ovarian cancers in animal models

Researchers at Baylor College of Medicine have identified a small molecule named 5D4 that can suppress the growth of breast and ovarian cancers in animal models.

25 Oct 2023

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

The research paper explores the multifaceted role of the IL-17 family in immune response, covering everything from infection control to pathological conditions like autoimmune diseases and cancer. Future therapies may exploit IL-17's unique signaling pathways to offer more targeted and cost-effective treatments.

12 Oct 2023

New topical drug shows promise in preventing cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma is the second most common type of skin cancer in the United States, impacting approximately 700,000 people each year.

11 Oct 2023

Scientists identify nearly a dozen genes responsible for coronary artery calcification

An international team of scientists has identified nearly a dozen genes that contribute to calcium buildup in our coronary arteries that can lead to life-threatening coronary artery disease, a condition responsible for up to one in four deaths in the United States.

11 Oct 2023

DNA aptamers: A versatile tool for regenerative medicine and beyond

Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine.

10 Oct 2023

Macrophages play a central role in intestinal cell renewal, study reveals

A research team from MedUni Vienna and the FWF-sponsored Special Research Area SFB F83 Immunometabolism has now demonstrated for the first time the central role of macrophages in the renewal of intestinal cells, which sheds light on the complex interplay between immune cells and tissue regeneration.

10 Oct 2023

Discovery of a novel therapeutic target for pancreatic cancer

A novel amino acid transporter-based therapeutic target for pancreatic ductal adenocarcinoma (PDAC).

10 Oct 2023

Drug combo safely decreases pancreatic cancer growth in mice

A new combination of treatments safely decreased growth of pancreatic cancer in mice by preventing cancer cells from scavenging for fuel, a new study finds.

9 Oct 2023

Study uncovers novel therapeutic target for osteoblastic lesions in prostate cancer bone metastasis

In a study published in the journal Genes & Diseases, researchers from Army Medical University and Shenzhen University investigated the pivotal role of miR-18a-5p, a microRNA, in the development and progression of osteoblastic lesions resulting from prostate cancer (PCa) bone metastasis.

9 Oct 2023

Signaling Pathway News and Research

New signaling mechanism implicated in the development of ventricular fibrillation

The future of functional foods: Leveraging Dendrobium officinale for optimal gut health and disease prevention

Mendelian randomization reveals a causal relationship between diabetes mellitus and pancreatic cancer

Microautophagy plays crucial role in lysosome repair, promoting healthy aging

Bacteria fight phages with RNA-based immune defense

Charting the future of IBD treatment: From immune modulators to microRNA therapies

Proteomic study pinpoints potential biomarkers for long-COVID diagnosis and persistent health impacts

Yabing Chen receives NIH grants to advance vascular disease research

New mechanism discovered for aspirin's cancer-fighting properties

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Study shows phages can promote mammalian cellular growth and survival

Newly identified small molecule can suppress growth of breast and ovarian cancers in animal models

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

New topical drug shows promise in preventing cutaneous squamous cell carcinoma

Scientists identify nearly a dozen genes responsible for coronary artery calcification

DNA aptamers: A versatile tool for regenerative medicine and beyond

Macrophages play a central role in intestinal cell renewal, study reveals

Discovery of a novel therapeutic target for pancreatic cancer

Drug combo safely decreases pancreatic cancer growth in mice

Study uncovers novel therapeutic target for osteoblastic lesions in prostate cancer bone metastasis

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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