Cell Metabolism News and Research

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Impaired energy production in heart muscle may underlie heart failure in some hypertensive patients

Many people with long-standing high blood pressure develop heart failure. But some don't. Daniel P. Kelly, M.D., and colleagues at Washington University School of Medicine in St. Louis and other institutions are trying to figure out what could explain that difference.

13 Aug 2007

Impaired energy production in heart muscle may underlie heart failure in some hypertensive patients

Many people with long-standing high blood pressure develop heart failure.

12 Aug 2007

New player in the control of HDL cholesterol

Researchers have identified a new player in the control of so-called "good" cholesterol that circulates in the bloodstream and reduces heart attack risk, according to a report in the August issue of Cell Metabolism, a publication of Cell Press.

8 Aug 2007

Bacteria - you can live without 'em, but it won't do you any good!

The finding challenges the conventional wisdom that even harmless bacteria – and the immune response they provoke – suck up the energy of the host organism and hasten its death.

8 Aug 2007

Suicide gene therapy for cancer

Cutting-edge research at South Dakota State University may yield a new therapy that targets only cancer cells, leaving healthy cells unharmed.

18 Jul 2007

Master switch for the production of brown fat discovered

Researchers at Dana-Farber Cancer Institute have identified a long-sought "master switch" in mice for the production of brown fat, a type of adipose tissue that generates heat and counters obesity caused by overeating.

11 Jul 2007

Adiponectin serves as energy-conserving signal to the brain

A fat-derived protein known for its effects on the liver and skeletal muscle might also serve as an energy-conserving signal to the brain during periods of starvation, suggests a new study in the July issue of Cell Metabolism, a publication of Cell Press.

11 Jul 2007

New regulator of fat metabolism identified

Over the past several years, animal studies have shown that high-fat, low-carbohydrate “ketogenic” diets cause demonstrable changes in metabolism and subsequent weight loss.

8 Jun 2007

Mouse hibernation hormones described

A key hormone enables starving mice to alter their metabolism and “hibernate” to conserve energy, revealing a novel molecular target for drugs to treat human obesity and metabolic disorders, UT Southwestern Medical Center researchers have found.

8 Jun 2007

Discovery of cellular processes which regulate heart's energy supply

The heart needs a steady supply of energy to function properly. MUHC researcher Dr. Vincent Gigure's and his colleagues recently identified several genetic programs which work together to ensure this energy is available.

10 May 2007

Global heartbeat control suggests therapy for beating heart failure

Keeping a healthy heart beating requires the production of a constant supply of energy, a feat depending on the coordination of several genetic programs.

9 May 2007

Plant chemical harmine fights diabetes in mice

After screening hundreds of compounds for their effects on fat development, researchers have discovered that an ingredient found in some plants fights diabetes in mice without some of the side effects attributed to other antidiabetes drugs.

9 May 2007

Study provides better understanding of how to treat individuals affected by copper imbalances

Copper is an essential part of our lives. From copper pipes and wires - to important copper-containing proteins in the body, copper is necessary for healthy growth and neurological development.

2 May 2007

Important new discovery in metabolomics

St. Jude investigators have mapped out many of the dynamic genetic and biochemical changes that make up a cell's response to a shortage of a molecule called Coenzyme A (CoA), a key player in metabolism.

27 Apr 2007

Researchers identify new player in the 'fat from food' game

UCLA investigators have identified a new molecule that may help regulate the delivery of fats to cells for energy and storage.

4 Apr 2007

Scientists identify new molecule that may help regulate the delivery of fats to cells

Published in the April issue of the journal Cell Metabolism, the finding could lead to a better understanding of how we utilize fats from the foods we eat.

4 Apr 2007

New 'platform' for processing dietary fat discovered

A new "platform" with a crucial role in the body's ability to process and take up fat from the diet has been found, according to a report in the April issue of the journal Cell Metabolism, published by Cell Press.

3 Apr 2007

Researchers discover factor that controls blood sugar's manufacture in a novel way

Researchers have discovered a factor that controls blood sugar's manufacture in a novel way: by limiting the supply of its building blocks. The findings are reported in the April issue of the journal Cell Metabolism, published by Cell Press.

3 Apr 2007

Researchers spot molecular player in insulin resistance and type 2 diabetes

Scientists at Weill Cornell Medical College have identified a protein called Rab10 as an important partner in the insulin-mediated uptake of glucose by cells, opening the way to potential new drug targets for the prevention and treatment of type 2 diabetes.

3 Apr 2007

Regulator of cholesterol production identified

By first probing the way primitive yeast make cholesterol, a team of scientists has discovered a long-sought protein whose human counterpart controls cholesterol production and potentially drug metabolism.

20 Feb 2007