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Scientists aim to develop business plan to guide drug development for potential use in patients

What if an experimental treatment for an aggressive breast cancer had the potential to save women's lives, but nobody could use it because there was no money to develop and test it? With funding sources for research and development more scarce than in the past, it is not an unusual situation. It's a problem that Sourav Sinha, a Master's degree candidate at Rutgers' Graduate School of Biomedical Sciences, is working to tackle head-on.

24 Jan 2014

American Humane and TGen uncover genetic basis of obsessive-compulsive disorder in dogs

Every year, one out of every 88 children in the United States is diagnosed with some form of autism, with these numbers steadily rising over the last decade. Alarmingly, it is believed that now one of every 54 young boys has some form of the disease.

24 Jan 2014

Focused ultrasound exam accurately identifies heart problems in athletes

A young athlete in seemingly excellent health dies suddenly from a previously undetected cardiovascular condition such as hypertrophic cardiomyopathy in nearly every U.S. state annually.

24 Jan 2014

Physical activity actively enhances longevity among cancer survivors

Physical activity significantly extends the lives of male cancer survivors, a new study of 1,021 men has found.

24 Jan 2014

Use of twice-daily pill could turn deadly blood cancer into highly treatable disease

Use of a twice-daily pill could turn a deadly blood cancer into a highly treatable disease, according to scientists at Weill Cornell Medical College who led a multinational research team.

24 Jan 2014

Study suggests potential therapeutic role of aspirin in inhibiting vestibular schwannoma growth

Researchers from Massachusetts Eye and Ear, Harvard Medical School, Massachusetts Institute of Technology and Massachusetts General Hospital have demonstrated, for the first time, that aspirin intake correlates with halted growth of vestibular schwannomas (also known as acoustic neuromas), a sometimes lethal intracranial tumor that typically causes hearing loss and tinnitus.

24 Jan 2014

Scientists develop mathematical model to predict tumor behavior and personalized therapies

Dana-Farber Cancer Institute scientists have developed a mathematical model to predict how a patient's tumor is likely to behave and which of several possible treatments is most likely to be effective.

24 Jan 2014

Etoposide plus cisplatin remains best for limited-stage SCLC

Etoposide plus cisplatin, given alongside accelerated hyperfractionated thoracic radiotherapy, remains the gold standard regimen for patients with limited-stage small-cell lung cancer, Japanese researchers say.

23 Jan 2014

Research reveals new information about the genetic complexity underpinning schizophrenia

The Icahn School of Medicine at Mount Sinai today announced the publication of two papers in the journal Nature that reveal new information about the genetic complexity underpinning schizophrenia. These collaborative studies represent the largest exome sequencing efforts to date to elucidate this mental illness, and together found that the disorder is likely caused by far more rare genetic mutations than previously suspected.

23 Jan 2014

New tools to increase precision and safety of radiation treatment in cancer patients

A scientific breakthrough may give the field of radiation oncology new tools to increase the precision and safety of radiation treatment in cancer patients by helping doctors "see" the powerful beams of a linear accelerator as they enter or exit the body.

23 Jan 2014

Researchers find definitive link between intimate partner violence and HIV risk

Researchers from The Miriam Hospital and the University of Rochester have found a definitive link between violence among intimate partners and an increased risk of HIV infection. The study is online in the journal Women & Health.

23 Jan 2014

Exposing adolescent to marijuana can lead to behavioral alterations in next generation

Exposing adolescent rats to THC (tetrahydrocannabinol) -the primary psychoactive ingredient in marijuana—can lead to molecular and behavioral alterations in the next generation of offspring, even though progeny were not directly exposed to the drug, researchers at the Icahn School of Medicine at Mount Sinai have found.

23 Jan 2014

Hispanic women twice as likely as white women to be affected by vulvodynia

Hispanic women surveyed in the metro Detroit area were twice as likely as white women to be affected by vulvodynia, unexplained vulvar pain that can make sex, tampon use or even sitting excruciating. Meanwhile, the condition affected half as many black women, new University of Michigan research shows.

23 Jan 2014

Clinician scientist receives RPB Career Development Award to support eye research

The Harvard Medical School (HMS) Department of Ophthalmology has been granted a $250,000 Research to Prevent Blindness (RPB) Career Development Award to support eye research conducted by Jason I. Comander, M.D., Ph.D. The support will be provided over a four-year period.

22 Jan 2014

Strategic placement of care managers in PCMHs can improve outcomes for high-risk diabetes patients

Patient centered medical homes (PCMHs) have been found to be an effective way to help care for patients with chronic diseases such as diabetes. Dr. Robert Gabbay, M.D., Ph.D., FACP, Chief Medical Officer and Senior Vice President at Joslin Diabetes Center, and his team conducted a study that shows the strategic placement of care managers in PCMHs can further improve patient outcomes for high-risk diabetes patients.

22 Jan 2014

Clues of "silent thief of sight”: Glaucoma

Glaucoma is sometimes called the "silent thief of sight" because it slowly damages the eyes and can cause irreparable harm before there is any vision loss. But this disease is stealthy in more ways than one.

22 Jan 2014

Study: CIEDs used by physicians today were approved as supplements to premarket approved models

The Food and Drug Administration (FDA) ensures that high-risk medical devices, such as implantable cardioverter-defibrillators and pacemakers, are safe and effective through its premarket approval (PMA) pathway, during which manufacturers must collect preclinical and clinical data before the device is approved.

From Medtronic 22 Jan 2014

Brain imaging via MRI scans may be useful biomarker for early detection of subtle developmental abnormalities

Researchers at Penn Medicine have generated a brain development index from MRI scans that captures the complex patterns of maturation during normal brain development.

22 Jan 2014

Scientists showcase HDL nanotherapy that may provide solution to repeat heart attacks

Up to 30 percent of heart attack patients suffer a new heart attack because cardiologists are unable to control inflammation inside heart arteries - the process that leads to clots rupturing and causing myocardial infarction or stroke.

22 Jan 2014

Kolltan Pharmaceuticals announces treatment of first cancer patient with KTN3379

Kolltan Pharmaceuticals, a privately held biopharmaceutical company, today announced treatment of the first cancer patient with Kolltan's lead drug candidate, KTN3379, as part of a Phase 1 clinical study evaluating safety, preliminary evidence of antitumor activity, and pharmacokinetics. KTN3379 is a human monoclonal antibody that blocks the activity of ErbB3, a member of the ErbB family of receptor tyrosine kinases.

21 Jan 2014

Medical School News and Research

Scientists aim to develop business plan to guide drug development for potential use in patients

American Humane and TGen uncover genetic basis of obsessive-compulsive disorder in dogs

Focused ultrasound exam accurately identifies heart problems in athletes

Physical activity actively enhances longevity among cancer survivors

Use of twice-daily pill could turn deadly blood cancer into highly treatable disease

Study suggests potential therapeutic role of aspirin in inhibiting vestibular schwannoma growth

Scientists develop mathematical model to predict tumor behavior and personalized therapies

Etoposide plus cisplatin remains best for limited-stage SCLC

Research reveals new information about the genetic complexity underpinning schizophrenia

New tools to increase precision and safety of radiation treatment in cancer patients

Researchers find definitive link between intimate partner violence and HIV risk

Exposing adolescent to marijuana can lead to behavioral alterations in next generation

Hispanic women twice as likely as white women to be affected by vulvodynia

Clinician scientist receives RPB Career Development Award to support eye research

Strategic placement of care managers in PCMHs can improve outcomes for high-risk diabetes patients

Clues of "silent thief of sight”: Glaucoma

Study: CIEDs used by physicians today were approved as supplements to premarket approved models

Brain imaging via MRI scans may be useful biomarker for early detection of subtle developmental abnormalities

Scientists showcase HDL nanotherapy that may provide solution to repeat heart attacks

Kolltan Pharmaceuticals announces treatment of first cancer patient with KTN3379

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