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Researchers identify ion channel switches that regulate dopamine release in the brain

Researchers have identified two ion channel switches that regulate the release of dopamine in the brain, a first step that might one day lead to therapeutics for a wide range of diseases and disorders that currently have few solutions.

11 Aug 2023

Scientists discover a therapeutic target for Alzheimer's disease

Scientists at Université Laval and the University of Lethbridge have succeeded in reversing certain cognitive manifestations associated with Alzheimer's disease in an animal model of the disease.

10 Aug 2023

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

Researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication.

10 Aug 2023

Mice lacking TMCO3 gene have shortened bones

Through next-generation sequencing, investigators have identified a mutation in the TMCO3 gene in two sisters with short stature.

9 Aug 2023

Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management

Study identifies gene fusions to understand their relationship with observed pathologies in cancer patients.

8 Aug 2023

Metrion Biosciences announces launch of Good Laboratory Practice (GLP) hERG Screening Service

Metrion Biosciences Limited, the specialist ion channel contract research and drug discovery company, today announced it has received notification from the UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) that the Company is now a member of the UK GLP (Good Laboratory Practice) Compliance Monitoring Programme, and is, therefore, able to offer GLP compliant hERG ion channel screening services to the global life sciences community.

From Metrion Biosciences Limited 7 Aug 2023

New technique enables high-resolution analysis of DNA

Function and form are deeply intertwined in biology. Knowing how organisms grow, adapt and reproduce requires understanding their physical structures. Hence the transformative power of the microscope across the past four centuries of science.

4 Aug 2023

Surprising new role for a key immune regulator revealed

A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

3 Aug 2023

Uncommon genetic allele variants may play a vital role in treatment-resistant depression, finds study

The association between treatment-resistant depression and uncommon functional genetic alleles.

3 Aug 2023

New drug shows promise for treating chronic neuropathic pain

A non-opioid designer molecule for treating chronic neuropathic pain by calming hyperactive pain-sensing neurons in the peripheral nervous system has had promising results in a preclinical study conducted by researchers at Weill Cornell Medicine and the Burke Neurological Institute.

2 Aug 2023

Two new subtypes of HPV+ head and neck cancers identified

Cases of human papillomavirus (HPV)-associated cancers of the head and neck, known as head and neck squamous cell carcinoma (HNSCC), are rapidly increasing throughout the United States.

31 Jul 2023

Newly identified protein plays a key role in the action of emerging anticancer therapies

Scientists have identified a protein that plays a pivotal role in the action of several emerging cancer therapies. The researchers say the discovery will likely aid efforts to fine-tune the use of immunotherapies against several challenging cancers.

31 Jul 2023

Trial evaluates purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

Researchers investigated the safety and pharmacokinetics of JNJ-54175446 in a double-blind, multicenter, randomized controlled trial (RCT).

31 Jul 2023

New gene therapy shows promise in reversing chronic pain

Researchers at NYU College of Dentistry's Pain Research Center have developed a gene therapy that treats chronic pain by indirectly regulating a specific sodium ion channel, according to a new study published in the Proceedings of the National Academy of Sciences.

27 Jul 2023

Long-term high fluoride exposure during adolescence causes hippocampal impairments

Researchers evaluated the impacts of prolonged fluoride exposure during adolescence and adulthood on cognition and associated hippocampal alterations.

13 Jul 2023

How the brain keeps blood sugar levels in check

The body's blood glucose level needs to be maintained in a relatively narrow range. It cannot be too high, as it can lead to diabetes, and it cannot be too low because it can cause fainting or even death.

11 Jul 2023

Columbia researchers develop first fully organic bioelectronic device

As researchers make major advances in medical care, they are also discovering that the efficacy of these treatments can be enhanced by individualized approaches.

10 Jul 2023

LIONESS: A new tool for unraveling mysteries of the brain

Brain tissue is one of the most intricate specimens that scientists have arguably ever dealt with. Packed with currently immeasurable amount of information, the human brain is the most sophisticated computational device with its network of around 86 billion neurons.

10 Jul 2023

New insights into the growth dynamics of mineral dendrites

An international research team involving scientists from the University of Vienna, the Faculty of Physics of the University of Warsaw and Univeristy of Edinburgh has described the process of growing three-dimensional manganese dendrites.

10 Jul 2023

Novel workflow reveals untapped diversity in fatty acid isomers across all life forms

Researchers introduced a comprehensive workflow to discover unsaturated fatty acids (FA).

6 Jul 2023

Ion News and Research

Researchers identify ion channel switches that regulate dopamine release in the brain

Scientists discover a therapeutic target for Alzheimer's disease

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

Mice lacking TMCO3 gene have shortened bones

Molecular insights: Detecting gene fusions offers new avenues for advanced cancer management

Metrion Biosciences announces launch of Good Laboratory Practice (GLP) hERG Screening Service

New technique enables high-resolution analysis of DNA

Surprising new role for a key immune regulator revealed

Uncommon genetic allele variants may play a vital role in treatment-resistant depression, finds study

New drug shows promise for treating chronic neuropathic pain

Two new subtypes of HPV+ head and neck cancers identified

Newly identified protein plays a key role in the action of emerging anticancer therapies

Trial evaluates purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

New gene therapy shows promise in reversing chronic pain

Long-term high fluoride exposure during adolescence causes hippocampal impairments

How the brain keeps blood sugar levels in check

Columbia researchers develop first fully organic bioelectronic device

LIONESS: A new tool for unraveling mysteries of the brain

New insights into the growth dynamics of mineral dendrites

Novel workflow reveals untapped diversity in fatty acid isomers across all life forms

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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