Germline News and Research

RSS

Study confirms no preexisting B-cell immunity against SARS-CoV-2 in pre-pandemic samples

A recent study finds that there is no considerable B-cell immunity against SARS-CoV-2 in unexposed healthy individuals.

23 Mar 2022

Study investigates germinal center of antibody-mediated immunity against SARS-CoV-2

In a new study, researchers explored the germinal center of antibody-mediated immunity towards SARS-CoV-2.

23 Mar 2022

Mayo Clinic researchers report differences in genomic data quality among racial groups

Mayo Clinic researchers studied the differences in genomic data quality among racial groups in one of the largest and most widely used cancer research datasets, The Cancer Genome Atlas.

17 Mar 2022

Study isolated largest panel of β-CoV broadly neutralizing antibodies to date

Researchers isolated a large panel of broadly neutralizing antibodies from COVID-19 recovered-vaccinated donors.

10 Mar 2022

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

A new study used glycoprotein profiling technology platform that couples high-resolution LC-MS for glycoprotein analysis in regards to COVID-19.

9 Mar 2022

Research reveals a possible strategy to prevent B-cell acute lymphoblastic leukemia

Short-term treatment with the drug ruxolitinib prevents B-cell acute lymphoblastic leukemia (B-ALL) in mice that have a genetic predisposition to the disease.

8 Feb 2022

Exploring receptor-blocking conserved non-neutralizing antibodies for SARS-CoV-2 therapy

In a new study, researchers hypothesized and developed broad-spectrum SARS-CoV-2 inhibitors, ReconnAbs, by modifying the existing non-neutralizing antibodies targeted towards the highly conserved epitopes of the SARS-CoV-2 spike (S) protein combined with a receptor-blocking component.

28 Jan 2022

Exploring loss of Y chromosome in white blood cells as a risk-factor of life-threatening COVID-19 in men

Researchers published a study exploring the possibilities of predisposing men for a life-threatening disease course of COVID-19.

24 Jan 2022

Human endogenous retrovirus type W envelope protein found to be a biomarker of COVID-19 severity

A new study revealed that the expression of HERV-W envelope protein (ENV) in lymphoid cells from COVID-19 patients correlated with disease outcome making them biomarkers of lymphocyte exhaustion.

24 Jan 2022

Researchers identify first known patients with BUB1 biallelic mutations

A new study published in Science Advances described the first two patients known to have mutations in both copies of BUB1, a critical gene for cell division.

20 Jan 2022

Researchers report isolation of potently neutralizing antibodies against highly transmissible SARS-CoV-2 variants

A recent preprint discusses using a combinatorial phage-display library approach to COVIID-19 antibodies.

18 Jan 2022

Broad cross-neutralization antibodies found to be effective against SARS-CoV-2 Omicron variant

A new study aimed to explore whether there is a way to induce the production of potent neutralizing antibodies capable of neutralizing all SARS-CoV-2 variants - including Omicron.

7 Jan 2022

Study analyzes the contribution of AI to cancer patient care and vaccine design

Artificial Intelligence/Machine Learning (AI/ML) is the development of computer systems that are able to perform tasks that would normally require human intelligence. AI/ML is used by people every day, for example, while using smart home devices or digital voice assistants.

8 Dec 2021

Systematic survey of human SARS-CoV-2 monoclonal antibodies

Scientists have mined information from several research publications and patents to create a dataset of approximately 8000 human antibodies to the SARS-CoV-2 spike from more than 200 donors.

2 Dec 2021

High prevalence of germline variants in Japanese patients with pheochromocytoma and paraganglioma

Certain kinds of tumors can be inherited within families. Identifying the underlying genetic cause is important in treatment, but most studies on these tumors have been carried out on Caucasian populations.

19 Nov 2021

Mechanisms and strategies for antibody binding and escape in SARS-CoV-2

A new study investigated the mechanisms for binding and strategies to escape several hNAbs used by SARS-CoV-2 strains through molecular simulations.

10 Nov 2021

Study points to a new, effective treatment option for patients with mesothelioma

Combining the immunotherapy agent durvalumab with the chemotherapy agents pemetrexed and cisplatin or carboplatin may provide a new treatment option for patients who have inoperable pleural mesothelioma, a cancer of the tissues lining the lungs, according to a phase II clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center and the Bloomberg~Kimmel Institute for Cancer Immunotherapy.

8 Nov 2021

Discovery of potent neutralizing antibodies against SARS-CoV-2 variants

In a recent study, the researchers identify and characterize mAbs that are effective against the wild-type SARS-CoV-2 strain and B.1.351 variant.

8 Nov 2021

CHOP-led network receives NIH-supported resources to unlock mysteries behind pediatric brain tumors

Unlocking the genetic mysteries behind pediatric brain tumors is at the heart of the mission of the Center for Data Driven Discovery in Biomedicine (D3b) at Children's Hospital of Philadelphia (CHOP). The Children's Brain Tumor Network (CBTN), a multi-institutional brain tumor research program with its operations center housed at D3b, has collected tumor samples from patients all over the world.

3 Nov 2021

Study suggests seropositive individuals produce anti-SARS-CoV-2 antibodies with improved potency and breadth

Researchers isolated single cells among individuals with and without prior infection with the SARS-CoV-2 vaccinated with BNT162b2 mRNA vaccine and compared the nature of the neutralizing antibody response against the original Wuhan virus and the subsequent variants.

25 Oct 2021