Lysine News and Research

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SARS-CoV-2 mutation T478K spreading at alarming speed in Mexico

Several SARS-CoV-2 variants have emerged, posing a renewed threat to COVID-19 containment and to vaccine and drug efficacy. In this study, we analyzed more than 820,000 SARS-CoV-2 genomic sequences deposited up to March 26, 2021 and identified a novel T478K mutation located on the SARS-CoV-2 Spike protein.

30 Mar 2021

New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

A new study describes the use of a combination of virtual and experimental screening protocols to identify potential inhibitors of the virus, which could lead to rapid drug development.

24 Mar 2021

Scientists explore structure of SARS-CoV-2 receptor-binding domain with G485R mutation

Researchers at the Bio21 Institute and Department of Biochemistry and Pharmacology, The University of Melbourne, studied the structure of a SARS-CoV-2 spike receptor-binding domain (RBD) with a G485R mutation. This mutation is a residue and not directly involved in interactions with the angiotensin-converting enzyme 2 (ACE2) residues but found in the Β1´/Β2' loop region.

18 Mar 2021

Study identifies how environmental information is transmitted by non-DNA molecules in the sperm

It has long been understood that a parent's DNA is the principal determinant of health and disease in offspring.

16 Mar 2021

Backtracking occurs within SARS-CoV-2 replication-transcription complex

Researchers continue to achieve a better understanding of SARS-CoV-2, the virus behind the ongoing COVID-19 pandemic. One such effort has been reported in a new preprint on the bioRxiv server, dealing with the phenomenon of backtracking.

16 Mar 2021

Chromatin-regulating enzyme found to be a key driver of common lung cancer

A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common type of lung cancer. Drugs that target the enzyme could improve treatment and survival rates for this particular cancer.

15 Mar 2021

Researchers identify epigenetic mechanism responsible for lifelong stress susceptibility

An epigenetic modification that occurs in a major cell type in the brain's reward circuitry controls how stress early in life increases susceptibility to additional stress in adulthood, researchers at the Icahn School of Medicine at Mount Sinai have learned.

15 Mar 2021

Vegan diet affects bone health, shows study

The vegan diet is on trend. How this type of diet affects health is the subject of scientific studies.

4 Mar 2021

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Researchers found a small molecule that inhibits different virus proteins and significantly reduces infection in cells. Combined with the antiviral remdesivir, its potency increases significantly, suggesting it may be a potential antiviral candidate for the treatment of COVID-19.

4 Mar 2021

Researchers explore how N501Y mutation in SARS-CoV-2 increases viral transmissibility

Researchers at Erasmus University Medical Center in The Netherlands have explored how and why new variants of SARS-CoV-2 have exhibited heightened infectivity.

24 Feb 2021

Two potent SARS-CoV-2 neutralizing antibodies effective against B.1.351 and B.1.1.7 variants

By analyzing the cryoEM structures of antibodies against the SARS-CoV-2 virus, researchers report that the neutralizing capabilities of two antibodies are not affected by new strains as these antibodies target regions of the virus away from the ACE2 binding regions.

23 Feb 2021

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

A new research paper recently uploaded to the preprint server bioRxiv by Jesse D. Bloom et al. (22nd Feb 2021) aims to map all of the currently circulating SARS-CoV-2 lineages with resistance towards LY-CoV555 and LY-CoV016, and document the specific mutations that confer resistance, ultimately suggesting that future monoclonal antibody cocktails should target a more diverse range of epitopes.

23 Feb 2021

E484K mutation is potentially associated with SARS-CoV-2 adaptive fitness

A team of Brazilian scientists has recently conducted genomic and phylogenetic analyses of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome to understand the viral evolution process better. Their analyses reveal that the E484K mutated variant of SARS-CoV-2 is present in three different lineages in four Brazilian regions and that the mutation may serve as a common solution for viral evolution.

31 Jan 2021

Lysine News and Research

SARS-CoV-2 mutation T478K spreading at alarming speed in Mexico

New covalent and non-covalent SARS-CoV-2 inhibitors discovered in silico

Scientists explore structure of SARS-CoV-2 receptor-binding domain with G485R mutation

Study identifies how environmental information is transmitted by non-DNA molecules in the sperm

Backtracking occurs within SARS-CoV-2 replication-transcription complex

Chromatin-regulating enzyme found to be a key driver of common lung cancer

Researchers identify epigenetic mechanism responsible for lifelong stress susceptibility

Vegan diet affects bone health, shows study

Study reveals a small molecule inhibits SARS-CoV-2 infection in cells

Researchers explore how N501Y mutation in SARS-CoV-2 increases viral transmissibility

Two potent SARS-CoV-2 neutralizing antibodies effective against B.1.351 and B.1.1.7 variants

SARS-CoV-2 mutations allow escape from clinical monoclonal antibodies

E484K mutation is potentially associated with SARS-CoV-2 adaptive fitness

Newly designed Biomesh minimizes postsurgical complications of hernia repair

Study reveals the role of SETD2 protein in cancer cells, cell migration, and autophagy

Researchers explain the role of enzyme that facilitates appropriate development of mouse embryo

Oral hormone therapy significantly alters the metabolome of postmenopausal women

Hybrid approach reveals details about genes involved in Meier-Gorlin syndrome

Researchers develop wound-healing gel based on a substance produced by Trichoderma fungi

N439K mutation of SARS-CoV-2 may be more infectious and antibody resistant than Wuhan strain

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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