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Metrion Biosciences and International Scientific Consortium publish data and new recommendations for in vitro risk assessment of the cardiac safety of new medicines

Metrion today announced it has contributed to two new peer-reviewed papers under the U.S. FDA CiPA (Comprehensive in vitro Proarrhythmia Assay) initiative.

From Metrion Biosciences Limited 7 Apr 2020

Study provides insights into pain signaling mechanism in the brain

Fast communication between our brain cells - or neurotransmission as it is called - is hugely important for our brain to work properly. Some of the messengers involved in this form of communication are neuropeptides, which are chemicals produced in the brain.

31 Mar 2020

Research shows how stress restructures the brain

Stress restructures the brain by halting the production of crucial ion channel proteins, according to research in mice recently published in JNeurosci.

25 Mar 2020

Cryo-electron microscopy helps visualize ball-and-chain inactivation of ion channels

Ion channels, which allow potassium and sodium ions to flow in and out of cells, are crucial in neuronal 'firing' in the central nervous system and for brain and heart function.

19 Mar 2020

A previously unknown mechanism could be new therapeutic target for cancer immunotherapy

Researchers at UC have discovered a previously unknown mechanism that could explain the reason behind decreased immune function in cancer patients and could be a new therapeutic target for immunotherapy for those with head and neck cancers.

10 Mar 2020

A highly conserved protein contributes to sensing mechanical pain, study shows

Researchers at McGill University have discovered that a protein found in the membrane of our sensory neurons are involved in our capacity to feel mechanical pain, laying the foundation for the development of powerful new analgesic drugs.

24 Feb 2020

Unveiling the structure of the influenza virus

The flu season is coming, and the frigid temperatures make it worse. The influenza B virus is the causative agent of the common flu, but over the past years, it has become more potent in causing disease. Now, a team of MIT scientists has found and unveiled the structure of the virus, particularly the key influenza protein, in the hopes to develop new drugs to combat influenza.

4 Feb 2020

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Integral Molecular, the leader in discovering antibodies against multipass membrane proteins, announces lead monoclonal antibodies (MAbs) against P2X7, a structurally complex ion channel that is the target for autoimmune disorders including atopic dermatitis and glomerulonephritis.

10 Jan 2020

Atomic-level structure of cardiac sodium channel

Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their function, malfunctions, disruption by many disease mutations, and response to medication.

20 Dec 2019

OU study explores how menthol's irritant sensation is transmitted by the nervous system

A new University of Oklahoma study could have implications on our understanding of how certain sensory signals are transmitted through the body.

18 Dec 2019

The Acoustics of the Brain: Random-access 3D Microscopy in Neuroscience

Máté Marosi and Zsolt Iván discuss the use of acousto-optic microscopes to study neural networks in the brain, from cell bodies to dendrites, to tiny spines.

From Femtonics Ltd. 17 Dec 2019

Study provides new insight into learning mechanisms of the cerebellum

In mere milliseconds trillions of chemical reactions ignite signals that travel across the billions of neurons in our brain. As we go through our daily lives and absorb new knowledge these neurons begin to modify themselves and change their signaling properties.

6 Dec 2019

Metrion and LifeArc extend neuroscience-focused ion channel drug discovery collaboration

Metrion Biosciences Limited, the specialist ion channel CRO and drug discovery company, and LifeArc, a leading UK independent medical research charity, today announced an extension of their neuroscience-focused ion channel drug discovery collaboration, following the success of the initial twelve-month agreement.

From Metrion Biosciences Limited 4 Dec 2019

New human colon-on-a-chip enables in vitro study of mucus physiology

We have a mutualistic but complicated relationship with the collection of microbes in our gut known as the intestinal microbiome.

3 Dec 2019

BGU researchers discover gene that causes nighttime atrial fibrillation

Genetic studies spanning three generations of a Persian Jewish family by researchers at Ben-Gurion University of the Negev. have identified a gene that causes nighttime atrial fibrillation (AFib).

18 Nov 2019

Understanding how pressure is regulated in the eye could lead to new treatments for glaucoma

Scientists in the University of Arizona Department of Physiology have identified a potential molecular mechanism that may hold the key to understanding how pressure is regulated in the eye.

14 Nov 2019

Cleveland Clinic researchers identify novel target for anti-fibrotic therapies

In a new study published in Science Signaling, Cleveland Clinic researchers have identified a novel target for new therapies that may help to treat or prevent a host of fibrotic conditions, which contribute to nearly half of overall mortality in the United States.

13 Nov 2019

Tulane virus needs intracellular calcium to replicate

Some gastrointestinal viruses need calcium. They need calcium ions to carry out several essential aspects of viral life, such as entry into host cells, genome replication and building new viruses to invade other cells. The cells invaded by viruses also use calcium. They use it as signals to regulate many of the cells' own processes, but viruses can takeover cellular calcium signaling to satisfy their own needs.

13 Nov 2019

Scientists identify new mechanism for the development of Parkinson's disease

An international research team including scientists from the University of Cologne have identified a new mechanism for the development of Parkinson's disease, which could prove to be the starting point for the development of a more targeted therapy.

12 Nov 2019