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Mechanistic connections between vascular health and dementia risk in older adults

A new review paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 10, entitled, "Peripheral vascular dysfunction and the aging brain."

12 Jun 2024

Germ cells drive sex-dependent lifespan differences in vertebrate animals

Women live longer than men. This isn't unique to humans, either; we see this trend in a wide range of other animals.

12 Jun 2024

Frailty as a major predictor of postoperative outcomes in elderly non-cardiac surgery patients

A new study of Medicare beneficiaries aged 65 and older undergoing non-cardiac surgeries has revealed that frailty is a significant predictor of postoperative outcomes, regardless of the type of surgery performed.

12 Jun 2024

Integration of genomics, epigenomics, and transcriptomics in understanding Alzheimer's pathogenesis

With the advent of new omics technologies in recent years, there has been a deluge of complex, high-dimensional data on Alzheimer's disease (AD).

12 Jun 2024

New AARF-D award supports Temple researchers to explore synapse function in the aging brain

Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia.

12 Jun 2024

Multi-center study validates systemic score in identifying high-risk patients with Still's disease

A multi-centre, observational, prospective study was designed to evaluate the clinical usefulness of the systemic score in predicting life-threatening evolution – defined as the development of macrophage activation syndrome (MAS) and/or mortality.

12 Jun 2024

Long-read RNA sequencing reveals novel insights into alternative splicing and disease genetics

Tokyo Medical and Dental University (TMDU) researchers harness long-read RNA sequencing to decode genetic intricacies and disease links.

12 Jun 2024

UC San Diego engineers develop algae-based microrobots for lung cancer treatment

Engineers at the University of California San Diego have developed microscopic robots, known as microrobots, capable of swimming through the lungs to deliver cancer-fighting medication directly to metastatic tumors.

12 Jun 2024

UNF researchers awarded U.S. patent for targeted cancer-fighting compound

Three University of North Florida (UNF) researchers have been awarded a U.S. patent for a targeted cancer-fighting compound, or peptoid, that the team has discovered targets certain breast, colon and lung cancers and stops them from progressing.

12 Jun 2024

Nutrients deficiency pattern possible important risk factor for mortality in older adults with hypertension

Researchers determine the impact of nutrient deficiencies on mortality risk in older adults with hypertension.

12 Jun 2024

Macrophages play an unexpected role in the complicated obesity-cancer connection

Immune system cells called macrophages play an unexpected role in the complicated connection between obesity and cancer, a Vanderbilt University Medical Center-led research team has discovered.

12 Jun 2024

Study identifies genetic predictors of X chromosome loss in aging women

Researchers have identified inherited genetic variants that may predict the loss of one copy of a woman's two X chromosomes as she ages, a phenomenon known as mosaic loss of chromosome X, or mLOX.

12 Jun 2024

Climate change-related environmental stressors associated with increased CVD mortality

Cardiovascular disease (CVD) is the leading cause of death worldwide, accounting for approximately one in every three deaths, with more than 20 million deaths reported in 2021 according to a 2024 World Heart Federation report.

12 Jun 2024

Rising syphilis cases highlight gaps in public knowledge on symptoms and treatment

Syphilis cases are on the rise around the globe, but many Americans don't know the symptoms.

12 Jun 2024

Nasal microbiota composition predicts sepsis with high accuracy in ICU settings

The nasal microbiota of intensive care unit (ICU) patients effectively distinguishes sepsis from non-septic cases and outperforms analyzing the gut microbiota to predict sepsis, according to a new study published in Microbiology Spectrum, a journal of the American Society for Microbiology.

12 Jun 2024

Enhancing CAR-T cell therapy with biodegradable scaffolds

CAR-T cell therapies are transforming the treatment of previously incurable blood cancers. Six approved CAR-T products have been administered to more than 20,000 people, and more than 500 clinical trials are underway.

12 Jun 2024

Combining anlotinib with STUPP regimen improves survival in glioblastoma patients

Glioblastoma multiforme (GBM) is among the most aggressive forms of brain tumors, with few effective treatment options and a bleak prognosis.

12 Jun 2024

First-in-human trial shows safety and efficacy of CAR T cell therapy for advanced prostate cancer

Treating prostate cancer with immunotherapy is currently difficult to do. But results from a first in-human phase 1 trial using a chimeric antigen receptor (CAR) T cell therapy developed by researchers from City of Hope, one of the largest cancer research and treatment organizations in the United States, showed that patients with advanced prostate cancer can be treated safely with the cellular immunotherapy with promising therapeutic activity, according to the phase 1 trial study published today in Nature Medicine.

12 Jun 2024

Inflammation in mid-life as a predictor of mobility decline in older age

In a recent study published in the Journal of the American Geriatric Society, having high inflammation in mid-life was associated with a clinically meaningful slower gait speed-;an indicator of mobility-;20 years later.

12 Jun 2024

Childhood sensitivity to parental praise predicts emotional development

A new study published in Developmental Science found that children who were more positively sensitive to their parents' praise when they were 3 years old had fewer behavioral and emotional problems when they were 5–7 years old.

12 Jun 2024

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Research News and Research

Mechanistic connections between vascular health and dementia risk in older adults

Germ cells drive sex-dependent lifespan differences in vertebrate animals

Frailty as a major predictor of postoperative outcomes in elderly non-cardiac surgery patients

Integration of genomics, epigenomics, and transcriptomics in understanding Alzheimer's pathogenesis

New AARF-D award supports Temple researchers to explore synapse function in the aging brain

Multi-center study validates systemic score in identifying high-risk patients with Still's disease

Long-read RNA sequencing reveals novel insights into alternative splicing and disease genetics

UC San Diego engineers develop algae-based microrobots for lung cancer treatment

UNF researchers awarded U.S. patent for targeted cancer-fighting compound

Nutrients deficiency pattern possible important risk factor for mortality in older adults with hypertension

Macrophages play an unexpected role in the complicated obesity-cancer connection

Study identifies genetic predictors of X chromosome loss in aging women

Climate change-related environmental stressors associated with increased CVD mortality

Rising syphilis cases highlight gaps in public knowledge on symptoms and treatment

Nasal microbiota composition predicts sepsis with high accuracy in ICU settings

Enhancing CAR-T cell therapy with biodegradable scaffolds

Combining anlotinib with STUPP regimen improves survival in glioblastoma patients

First-in-human trial shows safety and efficacy of CAR T cell therapy for advanced prostate cancer

Inflammation in mid-life as a predictor of mobility decline in older age

Childhood sensitivity to parental praise predicts emotional development

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