Acetylation News and Research

RSS

Acetylation (or in IUPAC nomenclature ethanoylation) describes a reaction that introduces an acetyl functional group into an organic compound. Deacetylation is the removal of the acetyl group.

HMGB1 as a key mediator in liver disease pathogenesis

Liver diseases, both acute and chronic, continue to pose significant clinical challenges due to high morbidity and mortality rates.

8 Nov 2024

Curcumin compound reactivates Epstein–Barr virus, offering safer cancer therapy

A novel curcumin derivative, C210, activates the Epstein–Barr virus (EBV) lytic cycle without producing infectious virions by disrupting HSP90. This discovery opens avenues for safer EBV-positive cancer therapies.

5 Nov 2024

RNA modifications and their role in cancer development

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications.

25 Oct 2024

Unraveling the mechanisms of B-cell maturation in blood cancer

Over four hundred people, 80% of them being children under 14 years old, will be diagnosed with B-cell Acute Lymphoblastic Leukaemia (B-ALL) next year in Spain, according to the latest projections from the Spanish network of cancer registries (REDECAN).

21 Oct 2024

Transposable elements found to be dysregulated in Alzheimer's brains, revealing potential targets for therapy

Study reveals widespread dysregulation of transposable elements (TEs) in aging human brains with Alzheimer's disease, using advanced techniques like CRISPR interference to identify TE-related risk genes.

9 Oct 2024

Environmental factors significantly impact gene expression through epigenetic modifications

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role in understanding the complex interplay between genetics and the environment. The review article "Epigenetics and Environmental Health" provides an in-depth analysis of how epigenetic modifications can influence the onset and progression of various diseases, particularly cancer and cardiovascular diseases.

8 Oct 2024

Innovative HiTIP-seq method advances epigenetic research in pediatric brain tumors

Diffuse midline glioma (DMG) is a highly aggressive and fatal pediatric high-grade glioma that primarily affects critical regions of the central nervous system, such as the pons, thalamus, and spinal cord.

24 Sep 2024

New histone tag discovery offers hope for myelin repair in neurodegenerative diseases

In a groundbreaking study, researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have identified a distinct histone tag in adult oligodendrocyte progenitor cells (OPCs) that may pave the way for innovative therapies targeting myelin repair, a critical target for several neurodegenerative and psychiatric disorders, including multiple sclerosis, Alzheimer's disease, and schizophrenia.

12 Aug 2024

Understanding the epigenetic regulation of hepatic stellate cells in NAFLD

Non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, affecting approximately 38% of the global population from 2016 to 2019.

25 Jul 2024

Synergistic cytotoxicity in pancreatic cancer: HDAC, PARP inhibitors, and decitabine show promise

A new research paper was published in Oncotarget's Volume 15 on June 3, 2024, entitled, "Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy."

5 Jun 2024

Mediterranean dietary adherence can reduce mortality risk in women

The association between Mediterranean diet adherence and any-cause mortality risk.

5 Jun 2024

Mediterranean diet linked to lower mortality risk in women

Investigators from Brigham and Women's Hospital identified and assessed underlying mechanisms that may explain the Mediterranean diet's 23 percent reduction in all-cause mortality risk for American women.

31 May 2024

Study reveals molecular changes in 19 organs due to exercise

The health benefits of exercise are well known but new research shows that the body's response to exercise is more complex and far-reaching than previously thought.

2 May 2024

Anti-cancer drug shows promise in treating brain injuries after stroke

A study by the Institut de Neurociències of the UAB (INc-UAB) demonstrates in animal models the benefits of vorinostat after having suffered a stroke.

28 Feb 2024

Study sheds light on the composition of nuclear matrix in Arabidopsis thaliana

Chromatin is a unique DNA and protein complex that makes up the chromosomes. Specific proteins (histones) wind up the DNA like small cable drums to package the long DNA.

23 Feb 2024

Ketogenic diet boosts brain's natural calm to combat epilepsy

A study in Cell Discovery shows the ketogenic diet increases brain GABA levels and the GABA/glutamate ratio through β-hydroxybutyric acid, offering a potential mechanism for its effectiveness in reducing epilepsy seizures.

15 Feb 2024

Mad2 expression levels with chromosomal abnormalities can be a biomarker for esophageal cancer

A new research paper was published in Oncotarget's Volume 15 on February 5, 2024, entitled, "Differential expression of Mad2 gene is consequential to the patterns of histone H3 post-translational modifications in its promoter region in human esophageal cancer samples."

12 Feb 2024

Wayne State researchers secure $1.4 million DoD grant for prostate cancer study

A team of researchers from Wayne State University was awarded a $1.4 million, three-year grant from the U.S. Department of Defense for the study, "Cytochrome c acetylation drives prostate cancer aggressiveness and Warburg effect."

7 Feb 2024

Angelica gigas extract emerges as a potential treatment for vascular disease

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction."

28 Dec 2023

Redefining the battle against Alzheimer's with tau-focused treatments

Researchers explore the potential of tau-targeting therapies in treating Alzheimer's disease, focusing on immunotherapies and strategies to improve their efficacy. The study dives into the complex biology of tau proteins, their modifications, and how they can be targeted to halt the progression of Alzheimer's.

29 Oct 2023