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Spatial arrangement of inhibitory connections shapes brain network criticality

In neuroscience, the brain criticality hypothesis proposes that neurons in the brain are arranged in such a way that neural activity lies at or near a transition point between two extremes: an ordered state where neural activity dies out quickly and a disordered state where neural activity tends to spread quickly and potentially grow uncontrollably.

13 Nov 2026

Your brain may reveal your Alzheimer’s risk before symptoms appear

Researchers developed the ARC brain connectivity score to distinguish cognitive resilience from vulnerability and improve early Alzheimer’s risk assessment.

13 Nov 2026

Single-cell spatial atlas profiles 850,000 cells across breast cancer progression

Researchers at The University of Texas MD Anderson Cancer Center have created one of the most detailed maps to date of the cell environment surrounding ductal carcinoma in situ (DCIS), the most common form of preinvasive, or stage 0, breast cancer.

13 Nov 2026

Scientists unveil first comprehensive atlas of basal ganglia cell types

Capturing a complete picture of what causes brain diseases from schizophrenia and Parkinson's disease to addiction has long remained a challenge to scientists.

12 Nov 2026

Human heart tissue model offers insights into inherited cardiomyopathy

Inherited cardiomyopathies - diseases of the heart muscle, which cause the heart to have a harder time pumping blood to the rest of the body - are the leading cause of heart failure in young adults.

12 Nov 2026

Inhaled living medicine reduces drug-resistant lung biofilms in the lungs of pigs

A "living medicine" has thinned biofilms of antibiotic-resistant Pseudomonas aeruginosa in the lungs of pigs, according to the findings of a study published today in the journal eBioMedicine.

12 Nov 2026

Immune and metabolic shifts drive acute pancreatitis into chronic disease

Pancreatitis is clinically classified into acute pancreatitis (AP) and chronic pancreatitis (CP). Most patients with AP recover without residual pancreatic dysfunction; a subset develops recurrent AP, and only selected high-risk individuals-particularly those with ongoing etiological exposure, genetic susceptibility, or severe necrotizing disease-progress to CP.

12 Nov 2026

Experimental vaccines aim to treat and prevent aggressive cancers

For more than three decades, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center researchers have pursued an ambitious idea: that vaccines could train the immune system to recognize and fight cancer.

12 Nov 2026

Richmond Pharmacology highlights encouraging first-in-human results for Regeneron's investigational RNAi therapy in MASLD

Richmond Pharmacology, a specialist early-phase clinical research organization, has announced encouraging results from a first-in-human clinical trial evaluating CIDEBsiRNA, an investigational RNA interference (RNAi) therapy developed by Regeneron Pharmaceuticals, Inc.

12 Nov 2026

Type 2 diabetes accelerates jawbone loss and causes tooth loss

Type 2 diabetes (T2D) is a chronic metabolic disorder whose global burden continues to rise. Beyond its systemic effects, T2D compromises skeletal health and markedly worsens loss of alveolar bone—the bone that anchors teeth—leading to tooth loosening, increased mobility, and eventual tooth loss.

11 Nov 2026

Environmental experiences trigger widespread changes in brain cell connections

Experiences and changes in environment cause widespread alterations in connections between brain cells, influencing brain activity, research suggests.

11 Nov 2026

Rare genetic mutation may protect against Parkinson's and Lewy body dementia

A rare genetic mutation may protect against developing Parkinson's disease and Lewy body dementia, a new study from researchers at Oregon Health & Science University suggests.

11 Nov 2026

Chronic stress promotes oral cancer through a brain–immune pathway

Chronic psychological stress is increasingly recognized as a risk factor for cancer, but how the brain communicates with the immune system to promote tumors has remained unclear.

11 Nov 2026

Exercise benefits mental health, so why is the genetic evidence so mixed?

A systematic review of 61 Mendelian randomization studies found limited and inconsistent genetic evidence that general physical activity causally improves mental health or cognitive outcomes; 30 studies reported only null or directionally opposite findings. More consistent evidence emerged for aerobic exercise and reduced depression risk, and for physical fitness traits, particularly muscle strength and muscle mass, in relation to better mental and cognitive health, although methodological limitations prevent definitive causal conclusions.

11 Nov 2026

Researchers identify previously unknown cause of fatal newborn brain disorder

Researchers at King Abdullah University of Science and Technology (KAUST) and King Faisal Specialist Hospital and Research Center (KFSHRC) identify a previously unknown cause of a fatal newborn brain disorder, giving long-awaited answers to families whose children were affected by the disease.

11 Nov 2026