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P-stalk ribosomes identified as key regulators of immune evasion in cancer

Research uncovers how P-stalk ribosomes regulate cytokine responses, driving immune evasion in tumors across multiple cancer types. It offers new insights into post-translational mechanisms influencing immunotherapy success.

23 Oct 2024

Genetic variant identified as potential predictor for severe ulcerative colitis

The HLA-DRB1*01:03 genetic variant is associated with severe ulcerative colitis, significantly raising the risk of major surgeries and hospitalizations.

21 Oct 2024

Genetic risk factors for long-COVID uncovered in a large multi-ethnic study

Researchers identified genetic loci and phenotypes linked to long-COVID in the largest multi-ethnic GWAS, revealing increased risk factors for chronic conditions like fatigue, depression, and fibromyalgia.

16 Oct 2024

Scientists detect replication-competent Oropouche virus in semen of traveler, sparking transmission fears

Researchers confirmed the presence of replication-competent Oropouche virus in semen, raising concerns about potential sexual transmission following a traveler's infection.

9 Oct 2024

Cardiovascular disease pathways associated with psoriasis, but not other immune-mediated diseases

A genetic connection between cardiovascular disease and psoriasis highlights shared inflammatory pathways, emphasizing the need for cardiovascular monitoring.

19 Sep 2024

Long COVID patients maintain robust immune memory two years after infection

Researchers discovered that SARS-CoV-2-specific T and B cells in long COVID patients are maintained for two years, similar to fully recovered individuals, offering insights into long-term immunity.

17 Sep 2024

Breakthrough metabolomic aging score that predicts mortality better than traditional methods

Researchers developed a metabolomic aging score using NMR biomarkers that predicts short-term mortality and disease risk more accurately than other aging metrics.

16 Sep 2024

Shorter leukocyte telomere length and greater LTL attrition tied to cystic fibrosis severity

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 16 on August 29, 2024, entitled, "Leukocyte telomere length and attrition in association with disease severity in cystic fibrosis patients."

12 Sep 2024

COVID-19 reduces male fertility by affecting semen quality and hormone levels

Study reveals that SARS-CoV-2 significantly impairs male fertility by reducing semen quality and altering reproductive hormone levels, with partial recovery post-treatment.

11 Sep 2024

New insights into stiff-person syndrome, advancing diagnosis and treatment

Research explores the complexities of diagnosing and treating stiff-person syndrome, emphasizing the uncertain role of GAD antibodies and the promise of novel therapies.

5 Sep 2024

The role of HPV in male fertility: New data on sperm quality and oxidative stress

Findings indicate HR-HPV infections affect sperm health, increasing oxidative stress and altering cytokine levels, emphasizing HPV's impact on male fertility.

27 Aug 2024

Osteoporosis and aging linked at cellular level

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 14, entitled, "Association between osteoporosis and the rate of telomere shortening."

5 Aug 2024

Exploring alemtuzumab in reduced-toxicity conditioning for Asian patients with inborn errors of immunity

Allogeneic hematopoietic cell transplantation (HCT) is a commonly used curative therapy for individuals with inborn errors of immunity (IEI).

28 Jul 2024

Long-term immune changes persist in unvaccinated COVID-19 patients

Study reveals that unvaccinated individuals experience significant long-term changes in immune parameters up to ten months post-COVID-19 infection, with a shift towards a Th2 cytokine profile.

21 Jul 2024

Novel peptide PEPITEM shows promise in fighting 'inflammaging'

A naturally occurring peptide called PEPITEM could potentially rejuvenate the immune response in older individuals and protect against 'inflammaging', which is widely believed to be the root cause of many age-related diseases.

18 Jul 2024

How lipoproteins shape your metabolic health

Study provides a comprehensive review of the lipoprotein pathway and its impact on healthy metabolism, highlighting the roles of HDL, LDL, and other lipoproteins in cardiovascular health and disease.

11 Jul 2024

Novel Co-STAR cells show promise in targeting and eradicating cancer

Using genetic engineering techniques, investigators at the Johns Hopkins Kimmel Cancer Center and its Ludwig Center, the Lustgarten Laboratory and Bloomberg~Kimmel Institute for Cancer Immunotherapy have designed a novel type of cell to recognize and fight cancer.