Phosphorylation News and Research

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Discovering how cells reorganize during division

A living cell is a bustling metropolis, with countless molecules and proteins navigating crowded spaces in every direction.

29 Oct 2024

RNA modifications and their role in cancer development

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications.

25 Oct 2024

P-stalk ribosomes identified as key regulators of immune evasion in cancer

Research uncovers how P-stalk ribosomes regulate cytokine responses, driving immune evasion in tumors across multiple cancer types. It offers new insights into post-translational mechanisms influencing immunotherapy success.

23 Oct 2024

The molecular underpinnings by which traumatic brain injury increases Alzheimer's disease risk

Findings indicate BAG3 modulation after traumatic brain injury may mitigate tau buildup and cognitive deficits, presenting a target for Alzheimer's prevention.

18 Oct 2024

New glucose-sensitive insulin NNC2215 could transform diabetes care by lowering hypoglycemia risk

NNC2215, a glucose-sensitive insulin, offers improved glycemic control by dynamically adjusting to blood sugar levels, reducing hypoglycemia in diabetes care.

18 Oct 2024

Novel method boosts MSC efficacy for articular cartilage repair

Researchers from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, alongside collaborators from the National University of Singapore Tissue Engineering Programme (NUSTEP), have developed a novel method to enhance the ability of mesenchymal stromal cells (MSCs) to generate cartilage tissue by adding ascorbic acid (AA) during MSC expansion.

18 Oct 2024

Researchers uncover the potential of JAK inhibitors to treat life-threatening skin disease

Researchers identified Janus kinase inhibitors as a promising treatment for the severe drug-induced skin condition toxic epidermal necrolysis, by analyzing patient biopsies with deep visual proteomics.

17 Oct 2024

New synthesis technology promises faster production of mRNA vaccines

In an era where viral outbreaks can escalate into global pandemics with alarming speed, the ability to quickly develop new vaccines has become crucial.

17 Oct 2024

Unique protein complex found to influence brain function and anxiety

Scientists at Université de Montréal and its affiliated Montreal Clinical Research Institute (IRCM) have uncovered unique roles for a protein complex in the structural organization and function of brain cell connectivity, as well as in specific cognitive behaviors.

12 Oct 2024

CKMT2 regulates mitochondrial function and energy metabolism in type 2 diabetes

Creatine kinase M2 (CKMT2) plays a key role in mitochondrial dysfunction in type 2 diabetes, affecting energy metabolism in skeletal muscle.

10 Oct 2024

Researchers uncover secret to regulating the body's internal clock

Scientists from Duke-NUS Medical School and the University of California, Santa Cruz, have discovered the secret to regulating our internal clock.

7 Oct 2024

KiNet web portal enhances study of kinase functions in cellular signaling pathways

Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These interactions play a vital role in modulating complex signaling pathways that control various cellular processes, such as cell growth, differentiation, and response to environmental stimuli.

4 Oct 2024

Researchers identify a protein that recharges T cells for long-lasting cancer remission

Research shows Fc–IL-4 revitalizes exhausted CD8+ T cells, boosting antitumor responses and highlighting the potential of combining type 1 and type 2 immunity.

30 Sep 2024

Researchers gain new understanding of how immune cells respond to heat during fever

The study reveals that moderate fever enhances CD4 T cell activity while reducing regulatory T cell suppression, highlighting temperature's immune effects.

25 Sep 2024

New insights into the mechanism of autophagy activation

24 Sep 2024

Scientists identify new trigger for autophagy

An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy, a self-degradation process cells use to eliminate unneeded or damaged components. In recent years, autophagy has also been recognized for its roles in aging and lifespan regulation.

24 Sep 2024

Blood microRNAs can predict conversion from mild cognitive impairment to dementia due to Alzheimer’s disease

This study identifies serum miRNA signatures as promising biomarkers for Alzheimer's, enhancing prediction of MCI conversion to AD with clinical relevance.

23 Sep 2024

Scientists pinpoint thousands of gene variants linked to breast and ovarian cancer risk

Scientists have pinpointed thousands of genetic changes in a gene that may increase a person's risk of developing breast and ovarian cancer, paving the way for better risk assessment and more personalised care.

18 Sep 2024

Activation of PPARβ/δ-AMPK pathway shown to slow liver fibrosis development

A study led by Manuel Vázquez Carrera, group leader at the Diabetes and Associated Metabolic Diseases Networking Biomedical Research Centre (CIBERDEM) at the University of Barcelona, reveals advances in the understanding and treatment of liver fibrosis, a serious complication in the context of metabolic fatty liver disease, also known as MASLD (metabolic dysfunction-associated steatotic liver disease).

17 Sep 2024

Salt can boost antitumor responses of T cells

Elevated sodium levels in tumors boost T-cell metabolic fitness and cytotoxicity, revealing potential avenues for improving cancer therapies.

13 Sep 2024

Phosphorylation News and Research

Discovering how cells reorganize during division

RNA modifications and their role in cancer development

P-stalk ribosomes identified as key regulators of immune evasion in cancer

The molecular underpinnings by which traumatic brain injury increases Alzheimer's disease risk

New glucose-sensitive insulin NNC2215 could transform diabetes care by lowering hypoglycemia risk

Novel method boosts MSC efficacy for articular cartilage repair

Researchers uncover the potential of JAK inhibitors to treat life-threatening skin disease

New synthesis technology promises faster production of mRNA vaccines

Unique protein complex found to influence brain function and anxiety

CKMT2 regulates mitochondrial function and energy metabolism in type 2 diabetes

Researchers uncover secret to regulating the body's internal clock

KiNet web portal enhances study of kinase functions in cellular signaling pathways

Researchers identify a protein that recharges T cells for long-lasting cancer remission

Researchers gain new understanding of how immune cells respond to heat during fever

New insights into the mechanism of autophagy activation

Scientists identify new trigger for autophagy

Blood microRNAs can predict conversion from mild cognitive impairment to dementia due to Alzheimer’s disease

Scientists pinpoint thousands of gene variants linked to breast and ovarian cancer risk

Activation of PPARβ/δ-AMPK pathway shown to slow liver fibrosis development

Salt can boost antitumor responses of T cells

Shaping the Future of Neuroscience: A Conversation with Atlas Antibodies on the MolBoolean™ and the Impact of SfN 2024

How the Arts Reshape Brain Function: Susan Magsamen on the Future of Neuroaesthetics

Inside the Alzheimer's Association: Dr. Heather Snyder on Driving Research and Collaboration

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