Radiotherapy News and Research

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Radiation therapy (in North America), or radiotherapy (in the UK and Australia) also called radiation oncology, and sometimes abbreviated to XRT, is the medical use of ionizing radiation as part of cancer treatment to control malignant cells (not to be confused with radiology, the use of radiation in medical imaging and diagnosis).

Long non-coding RNAs offer new pathways to overcome cancer treatment resistance

Scientists are highlighting long non-coding RNAs (lncRNAs) as promising targets in the effort to overcome one of cancer treatment's most persistent challenges: therapeutic resistance.

12 Oct 2026

What young cancer survivors revealed about stress, exercise and friendship

Adolescent and young adult cancer survivors use exercise and social support to cope with stress, revealing insights for effective mental health interventions.

9 Oct 2026

Disrupted circadian rhythms may influence tumor immunity and cancer spread

Epidemiological studies link light at night (LAN), shift work, chronic jet lag (CJL), and core clock gene mutations to higher cancer risk and aggressive spread, especially in breast and colorectal cancer.

8 Oct 2026

Mini-GRID radiotherapy limits cellular senescence in glioma models

A new research paper was recently published in Volume 18 of Aging, titled "Spatially fractionated mini-GRID radiotherapy differentially modulates radiation-induced senescence in murine glioma and normal cells."

6 Oct 2026

Phase III trial tests MRD-guided treatment for patients with ER-positive/HER2-negative breast cancer

Alliance Foundation Trials, LLC (AFT), a national leader in conducting innovative, practice-changing cancer clinical trials, and Natera, Inc., a global leader in cell-free DNA and precision medicine, today announced the launch of AFT-70 NAVIGATE, a randomized phase III trial evaluating a novel molecular residual disease (MRD)-guided treatment strategy for patients with intermediate and high-risk ER-positive/HER2-negative early breast cancer.

5 Oct 2026

Esophageal cancer leaves a distinct metabolic signature in the gut

The study uncovers gut microbial and metabolic signatures in esophageal cancer, emphasizing lipid dysregulation and its potential role in disease progression.

1 Oct 2026

Neck lymph node removal surgery may disrupt brain waste clearance

Surgery to remove lymph nodes in the neck may interfere with cerebrospinal fluid (CSF) drainage from the brain, contributing to cognitive impairment, according to new multicenter research led by Weill Cornell Medicine scientists.

29 Sep 2026

Five-session SBRT preserves quality of life before pancreatic cancer surgery

Patients preparing for pancreatic cancer surgery maintained better physical function and experienced less fatigue with five treatments of stereotactic body radiation therapy (SBRT) than with 28 treatments of conventional radiation therapy given with chemotherapy, according to a randomized phase 2 clinical trial.

28 Sep 2026

Five-treatment radiation provides excellent long-term prostate cancer control

Five-treatment stereotactic body radiation therapy (SBRT) provided excellent long-term cancer control with fewer urinary and sexual side effects than surgery in the first randomized trial to directly compare the treatments for localized prostate cancer.

28 Sep 2026

Focused radiosurgery extends survival for small cell lung cancer patients with brain metastases

Patients with small cell lung cancer (SCLC) that had spread to the brain lived a median of 17 months after focused stereotactic radiosurgery, compared with nine months after an advanced form of whole brain radiation therapy, an unexpected secondary finding from the first randomized phase 3 trial to compare the treatment approaches in this population.

28 Sep 2026

Prostate cancer biology helps identify hormone therapy candidates

A recent analysis of the NRG-RTOG 0534 "SPPORT" clinical trial evaluated the Luminal B (LumB) molecular subtype using the PAM50 genomic classifier to determine whether tumor biology could help identify patients most likely to benefit from hormone therapy.

27 Sep 2026

Low-dose radiation shows lasting benefits in patients with knee osteoarthritis

Low-dose radiation therapy may do more than relieve pain from early knee osteoarthritis, with a long-term analysis suggesting it could also influence how the disease progresses.

27 Sep 2026

$Hypofractionated radiotherapy for prostate cancer matches conventional treatment outcomes$

Hypofractionated radiotherapy for prostate cancer matches conventional treatment outcomes

Men with high-risk prostate cancer have a higher likelihood of having residual disease following prostatectomy and may require radiation therapy after surgery, particularly when PSA levels begin to rise. Conventional postprostatectomy radiotherapy (COPORT) is typically delivered over 37 fractions, while hypofractionated postprostatectomy radiotherapy (HYPORT) delivers a slightly lower total radiation dose over just 25 fractions.

27 Sep 2026

Ultra-low-dose radiation therapy eases painful bone lesions in multiple myeloma

A short course of ultra-low-dose radiation therapy relieved painful bone lesions from multiple myeloma for most patients in a multi-institutional phase 2 clinical trial.

27 Sep 2026

MD Anderson researchers showcase new findings in radiation oncology at ASTRO 2026

Experts from The University of Texas MD Anderson Cancer Center will present nearly 70 abstracts at the 2026 American Society for Radiation Oncology (ASTRO) Annual Meeting.

25 Sep 2026

UCLA researchers present new radiation advances at ASTRO 2026

Physicians and scientists from the UCLA Health Jonsson Comprehensive Cancer Center will share new research and clinical trial findings at the 2026 American Society for Radiation Oncology (ASTRO) Annual Meeting, including studies on new treatment approaches for prostate, bile duct and head and neck cancers, personalized radiation therapy based on genetic risk, and advances in targeted radiation and radioligand therapy designed to improve cancer control while limiting treatment side effects.

25 Sep 2026

Review highlights emerging treatments for glioblastoma multiforme

A new research perspective was published in Volume 13 of Oncoscience on September 17, 2026, titled "Emerging pharmacological agents for glioblastoma multiforme: An update on active clinical trials (2025–2026)."

25 Sep 2026

Radiotherapy lowers recurrence of atypical meningiomas, study shows

Atypical meningiomas are tumors originating in the meninges and are associated with a high risk of recurrence.

25 Sep 2026

Engineered nanoparticles sensitize gliomas to radiotherapy

Gliomas are a major cause of cancer-related deaths in younger adults.

24 Sep 2026

Early consolidative SRT shows value in EGFR-mutant NSCLC with limited brain metastases

Early cranial stereotactic radiotherapy (SRT) administered with first-line osimertinib was associated with improved intracranial control and survival outcomes in patients with EGFR-mutant non-small cell lung cancer (NSCLC) and limited brain metastases, according to research presented at the International Association for the Study of Lung Cancer (IASLC) 2026 World Conference on Lung Cancer (WCLC).

15 Sep 2026