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The pain-reliever acetaminophen (also known as paracetomol) is one of the best-selling over-the-counter medications, used by more than 200 million Americans a year. It is sold under many brand names, including Tylenol, and is an ingredient in nearly 200 medications, both over-the-counter (such as Excedrin, Midol, NyQuil, and Sudafed) and prescription (such as Vicodin).
Revised CPG on treatment of osteoarthritis of the knee addresses two key changes

Revised CPG on treatment of osteoarthritis of the knee addresses two key changes

The American Academy of Orthopaedic Surgeons recently released its revised clinical practice guideline on the treatment of osteoarthritis of the knee, addressing two key changes. [More]
New paper analytical devices can screen fake antimalarial drugs

New paper analytical devices can screen fake antimalarial drugs

On Wednesday, 5/29/13, the Wall Street Journal published an article titled "Africa's Malaria Battle: Fake Drug Pipeline Undercuts Progress." The piece outlines a counterfeit pharmaceutical problem that is top of mind at Saint Mary's College in Notre Dame, IN. Chemistry Professor Toni Barstis and her undergraduate students at this Catholic, women's, liberal arts college have researched and developed Paper Analytical Devices (PADs) that can screen whether an antimalarial drug is real. [More]
Studies show that LipiGesic M provides highly effective OTC solution to migraine pain

Studies show that LipiGesic M provides highly effective OTC solution to migraine pain

PuraMed BioScience, Inc., a researcher, developer, and marketer of over-the-counter medicinal and healthcare products, announced the results of clinical trials that found its over-the-counter migraine medication product, LipiGesic M, has "robust efficacy". [More]
Childhood respiratory infections rather than analgesics usage linked to risk for asthma

Childhood respiratory infections rather than analgesics usage linked to risk for asthma

A new study conducted by Boston researchers reports that the link between asthma and early childhood use of acetaminophen or ibuprofen may be driven by underlying respiratory infections that prompt the use of these analgesics, rather than the drugs themselves. [More]
Viewpoints: Liberals refuse to acknowledge evidence of Oregon Medicaid study; Politics is roiling science in emergency contraception decisions

Viewpoints: Liberals refuse to acknowledge evidence of Oregon Medicaid study; Politics is roiling science in emergency contraception decisions

A familiar critique of liberal governance is that the results always matter less than its grand social ambitions. The latest evidence of this truth comes in the reaction to disappointing new findings from one of the most important public-policy experiments since the 1970s. A team of varsity health economists, mostly at Harvard and MIT, is studying the relationship between health outcomes and health insurance delivered by Medicaid (5/2). [More]
Acetaminophen may help reduce existential pain

Acetaminophen may help reduce existential pain

Thinking about death can cause us to feel a sort of existential angst that isn't attributable to a specific source. Now, new research suggests that acetaminophen, an over-the-counter pain medication, may help to reduce this existential pain. [More]
GABA neuronal deficits in psychiatric disorder can be prevented using N-acetylcysteine: Study

GABA neuronal deficits in psychiatric disorder can be prevented using N-acetylcysteine: Study

Gamma-aminobutyric acid (GABA) deficits have been implicated in schizophrenia and depression. In schizophrenia, deficits have been particularly well-described for a subtype of GABA neuron, the parvalbumin fast-spiking interneurons. [More]

Aspirin's anti-inflammatory effects may help protect against melanoma

A new study has found that women who take aspirin have a reduced risk of developing melanoma-and that the longer they take it, the lower the risk. The findings suggest that aspirin's anti-inflammatory effects may help protect against this type of skin cancer. The study is published early online in CANCER, a peer-reviewed journal of the American Cancer Society. [More]

Laboratorios Grifols, Cadence announce new supply agreement for OFIRMEV

Cadence Pharmaceuticals, Inc., a biopharmaceutical company focused on acquiring, in-licensing, developing and commercializing proprietary products principally for use in the hospital setting, today announced a new supply agreement with Laboratorios Grifols, S.A. for the development, manufacture and supply of commercial quantities of OFIRMEV (acetaminophen) injection in flexible plastic bags. [More]
USP evaluates Raman device's potential to detect counterfeit and substandard medicines

USP evaluates Raman device's potential to detect counterfeit and substandard medicines

With substandard and counterfeit medicines a dangerous and growing problem in the developing world and elsewhere, identifying new technologies to detect such drugs is an urgent matter. In a new study published in the Journal of Pharmaceutical and Biomedical Analysis, scientists from the U.S. Pharmacopeial Convention (USP) evaluated a handheld Raman device's potential to detect counterfeit and substandard medicines. [More]

SPI Pharma launches Actimask Ibuprofen 92S

SPI Pharma, Inc., a global leader in providing pharmaceutical ingredients and technologies for patient-friendly dosage forms, announces the launch of Actimask Ibuprofen 92S, a taste-masked Ibuprofen. [More]
Biomarkers could be antidote to overdose overtreatment

Biomarkers could be antidote to overdose overtreatment

Researchers have identified several biomarkers that can accurately predict acute liver injury after acetaminophen overdose. [More]
Ibuprofen and naproxen can cause kidney damage in children

Ibuprofen and naproxen can cause kidney damage in children

Sick children, especially those with some dehydration from flu or other illnesses, risk significant kidney injury if given drugs such as ibuprofen and naproxen, Indiana University School of Medicine researchers said Friday. [More]

NSAIDs cause acute kidney injury in some children

Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, are commonly used to treat pain and reduce fever in children. However, the use of NSAIDs has been shown to cause acute kidney injury (AKI) in some children [More]

Acetaminophen may improve postoperative outcomes

Prophylactically administered intravenous acetaminophen could reduce postoperative nausea and vomiting, research suggests. [More]
Morphine not first choice after neonatal surgery

Morphine not first choice after neonatal surgery

Neonates and infants undergoing major surgery should be treated with postoperative intermittent intravenous acetaminophen as opposed to continuous morphine, research suggests. [More]
Novartis to highlight key data from extensive oncology portfolio at SABCS and ASH meeting

Novartis to highlight key data from extensive oncology portfolio at SABCS and ASH meeting

Novartis will highlight more than 140 presentations on key data from its extensive oncology portfolio at the leading year-end scientific meetings devoted to hematology and breast cancer, demonstrating continued innovation in research and development efforts to advance the care of patients with cancer and rare diseases. [More]
KemPharm announces successful Type B meeting with FDA for KP201

KemPharm announces successful Type B meeting with FDA for KP201

KemPharm, Inc., a clinical stage biopharmaceutical company focused on the discovery and development of new, safer therapies to treat pain, announced today a successful Type B meeting with the Food and Drug Administration (FDA) for its lead pain candidate, KP201. [More]

Aspirin associated with reduced risk of serious ovarian cancer

New research shows that women who regularly use pain relief medications, particularly aspirin, have a decreased risk of serious ovarian cancer—an aggressive carcinoma affecting the surface of the ovary. [More]

New ToxIC study identifies current drug poisoning trends

Nonprescription medications are just as likely a cause of poisoning as prescription drugs, according to a new study by Timothy Wiegand, M.D. from the University of Rochester Medical Center in the US and colleagues. [More]