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Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a ß-N9-glycosidic bond.
Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy-induced neuropathy and HIV. [More]
Surveillance machinery in cells recognizes and destroys defective genetic material, research shows

Surveillance machinery in cells recognizes and destroys defective genetic material, research shows

New research out of Case Western Reserve University School of Medicine describes a mechanism by which an essential quality control system in cells identifies and destroys faulty genetic material. The findings were published online December 23 in Nature Communications. [More]
Researcher develops new method to accurately identify elusive molecules

Researcher develops new method to accurately identify elusive molecules

Among the most important molecules in the living world are sugars or carbohydrates, which play a vital role in life processes. Sugars provide the main source of fuel for the body, protect muscles from damage and contribute to the immune response. [More]
Replacing missing gut bacteria could help treat children with rare autoimmune disease

Replacing missing gut bacteria could help treat children with rare autoimmune disease

Defects in the body's regulatory T cells (T reg cells) cause inflammation and autoimmune disease by altering the type of bacteria living in the gut, researchers from The University of Texas Health Science Center at Houston have discovered. [More]
Research shows corticotrophs in the brain can influence avoidance behavior after onset of stress

Research shows corticotrophs in the brain can influence avoidance behavior after onset of stress

German Resilience Center presents new findings on the resistance to stress. A person exposed to stress can usually rapidly adapt the own behavior to the specific situation. [More]
Scientists investigate role of mitochondria in Alzheimer's disease pathology

Scientists investigate role of mitochondria in Alzheimer's disease pathology

On Nov. 25, 1901, a 51-year-old woman is admitted to a hospital in Frankfurt, Germany, displaying a bizarre constellation of symptoms. [More]
Zika virus infections modify viral and human genetic material, research finds

Zika virus infections modify viral and human genetic material, research finds

Researchers at University of California San Diego School of Medicine have discovered that Zika virus infection leads to modifications of both viral and human genetic material. [More]
TUM scientists uncover novel mechanisms of action for skin disease medication

TUM scientists uncover novel mechanisms of action for skin disease medication

Imiquimod is a medication successfully used in the treatment of skin diseases. In addition to its known mechanism of action, it also triggers other processes in the body. [More]
Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

Domain Therapeutics, a biopharmaceutical company that specializes in the discovery and development of G protein-coupled receptor (GPCR) drugs, today announces the creation of Mavalon Therapeutics, a company focused on stopping the progression of Parkinson’s disease. [More]
Study sheds new light on role of Tau proteins in certain brain diseases

Study sheds new light on role of Tau proteins in certain brain diseases

In a study published in the journal PNAS scientists of the German Center for Neurodegenerative Diseases present new findings on the role of the protein Tau in certain brain diseases. [More]
Researchers discover how appetite is controlled and influenced by the brain

Researchers discover how appetite is controlled and influenced by the brain

Researchers from Daegu Gyeongbuk Institute of Science and Technology in Korea have uncovered the mechanisms behind the enzyme that controls our appetite in response to low glucose availability in the brain. [More]
DGIST researchers uncover mechanisms that control appetite during low glucose conditions in the brain

DGIST researchers uncover mechanisms that control appetite during low glucose conditions in the brain

Researchers from Daegu Gyeongbuk Institute of Science and Technology (DGIST) in Korea have uncovered the mechanisms behind the enzyme that controls our appetite in response to low glucose availability in the brain. [More]
CUMC researchers uncover new details of intracellular channel that controls skeletal muscle

CUMC researchers uncover new details of intracellular channel that controls skeletal muscle

Using high-resolution electron microscopy, Columbia University Medical Center researchers have uncovered new details of the structure and function of an intracellular channel that controls the contraction of skeletal muscle. [More]
Clinical scientists find new way to treat hypertension

Clinical scientists find new way to treat hypertension

A team of clinical scientists at the University of Bristol have found a new way to treat high blood pressure (hypertension). [More]
Researchers identify potential new way of treating hypertension

Researchers identify potential new way of treating hypertension

Researchers eyeing first new anti-hypertensive drug treatment strategy in more than 15 years. [More]
Adenosine may play role in inhibiting REM sleep

Adenosine may play role in inhibiting REM sleep

The regulation and function of sleep is one of the biggest black boxes of today's brain science. [More]
Study shows how caffeine counteracts age-related cognitive deficits in animals

Study shows how caffeine counteracts age-related cognitive deficits in animals

A study published in the journal Scientific Reports from Nature publishing group, describes the mechanism by which caffeine counteracts age-related cognitive deficits in animals. [More]
Researchers identify unique mechanism to suppress colorectal cancer tumors in mice

Researchers identify unique mechanism to suppress colorectal cancer tumors in mice

A new scientific study has identified why colorectal cancer cells depend on a specific nutrient, and a way to starve them of it. Over one million men and women are living with colorectal cancer in the United States. [More]
New mass spectrometry imaging protocol allows analysis of metabolite composition of tissues

New mass spectrometry imaging protocol allows analysis of metabolite composition of tissues

In biomedical research, working with tissue samples is indispensable because it permits insights into the biological reality of patients, for example, in addition to those gained from Petri dishes and computer simulations. [More]
Scientists identify timing of major metabolic shift in developing neurons

Scientists identify timing of major metabolic shift in developing neurons

Our brains can survive only for a few minutes without oxygen. Salk Institute researchers have now identified the timing of a dramatic metabolic shift in developing neurons, which makes them become dependent on oxygen as a source of energy. [More]
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