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Adenoviruses most commonly cause respiratory illness; however, depending on the infecting serotype, they may also cause various other illnesses, such as gastroenteritis, conjunctivitis, cystitis, and rash illness. Symptoms of respiratory illness caused by adenovirus infection range from the common cold syndrome to pneumonia, croup, and bronchitis. Patients with compromised immune systems are especially susceptible to severe complications of adenovirus infection. Acute respiratory disease (ARD), first recognized among military recruits during World War II, can be caused by adenovirus infections during conditions of crowding and stress.
Experimental vaccine/immune stimulant combination may lead to viral remission in HIV patients

Experimental vaccine/immune stimulant combination may lead to viral remission in HIV patients

A study led by researchers at Beth Israel Deaconess Medical Center, in collaboration with scientists at Walter Reed Army Institute of Research, Janssen Vaccines & Prevention B.V., one of the Janssen Pharmaceutical Companies of Johnson & Johnson and Gilead Sciences, Inc., has demonstrated that combining an experimental vaccine with an innate immune stimulant may help lead to viral remission in people living with HIV. [More]
Investigational treatment combination improves virologic control in SIV-infected monkeys

Investigational treatment combination improves virologic control in SIV-infected monkeys

Researchers have found that an investigational treatment combination of a therapeutic vaccine and an immune-stimulator improves virologic control and delays viral rebound following the discontinuation of antiretroviral therapy (ART) in non-human primates infected with SIV, the simian form of HIV. [More]
DNAtrix enters into license agreement with University of Florida to develop new oncolytic virus platform

DNAtrix enters into license agreement with University of Florida to develop new oncolytic virus platform

DNAtrix, a clinical stage biotechnology company developing virus-driven immunotherapies for cancer, announced it has entered into an exclusive license agreement with the University of Florida, Gainesville to develop a novel oncolytic virus platform. [More]
Study provides unprecedented insights into causes of childhood diarrhea

Study provides unprecedented insights into causes of childhood diarrhea

New research offers unprecedented insights into the causes of childhood diarrhea, the second-leading cause of death of children worldwide, and suggests that the role of pathogens such as bacteria, viruses and parasites has been vastly underestimated. [More]
Two Zika vaccine candidates protect newborn mice against neurological damage

Two Zika vaccine candidates protect newborn mice against neurological damage

Two vaccines against Zika virus developed at the University of Pittsburgh School of Medicine have successfully conveyed immunity from female mice to pups conceived weeks after the mother's vaccination. [More]
Study offers unprecedented quantification of pathogens that cause childhood diarrhea

Study offers unprecedented quantification of pathogens that cause childhood diarrhea

New research offers unprecedented insights into the causes of childhood diarrhea, the second-leading cause of death of children worldwide, and suggests that the role of pathogens such as bacteria, viruses and parasites has been vastly underestimated. [More]
New research shows childhood diarrhea cases significantly higher than estimated

New research shows childhood diarrhea cases significantly higher than estimated

The number of cases of childhood diarrhoea attributable to pathogens (bacteria, parasites, viruses or other infections) have been substantially underestimated and may be nearly twice as high as previous analysis suggests, according to new research published in The Lancet. [More]
Three vaccine candidates provide complete protection against Zika virus in rhesus monkeys

Three vaccine candidates provide complete protection against Zika virus in rhesus monkeys

A month after announcing that two promising vaccine candidates provided mice with complete protection against the Zika virus, a research team at Beth Israel Deaconess Medical Center, in collaboration with scientists at Walter Reed Army Institute of Research and the University of São Paulo, now reports achieving complete protection against Zika virus in rhesus monkeys. [More]
Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

“IDPs” is now a widely used acronym that stands for “intrinsically disordered proteins.” It is the term generally used by the scientific community to refer to a wide variety of proteins that do not have a stable 3D structure and are instead characterized by a high extent of local mobility, disorder and many conformers that are accessible at room temperature. [More]
Researchers reveal novel mechanism by which viral protein VII suppresses immune alarm signals

Researchers reveal novel mechanism by which viral protein VII suppresses immune alarm signals

Viruses must avoid a host's immune system to establish successful infections—and scientists have discovered another tool that viruses use to frustrate host defenses. [More]
Two Ebola vaccine candidates show promise in clinical trial

Two Ebola vaccine candidates show promise in clinical trial

An immunization regimen using two Ebola vaccine candidates was safe and well-tolerated and induced an immune response in healthy adult volunteers in a Phase 1 clinical trial. [More]
Genetic modification of common virus gives extra weapon to kill cancer cells

Genetic modification of common virus gives extra weapon to kill cancer cells

A common flu virus could be used to overcome patients' resistance to certain cancer drugs -- and improve how those drugs kill cancer cells, according to new research from Queen Mary University of London. [More]
Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

Researchers report photoimmunotherapy to be effective against elusive gastric cancer cells following transduction with the gene that expresses the extracellular domain protein of HER2. The results are published in the journal Small Molecule Therapeutics in February 2016. [More]
Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Researchers show that the protein CCN4 positively regulates the generation of cartilage matrix, which are depleted in osteoarthritis. [More]
Swedish research group publishes scientific discoveries concerning EKC in Acta Ophthalmologica journal

Swedish research group publishes scientific discoveries concerning EKC in Acta Ophthalmologica journal

A Swedish research group at St. Erik Eye Hospital, Stockholm, Karolinska Institutet, Solna, and Umeå University has published scientific discoveries concerning the serious infectious eye disease EKC in the prestigious journal Acta Ophthalmologica. [More]
Combination treatment provides effective one-two punch against prostate cancer

Combination treatment provides effective one-two punch against prostate cancer

Results from a long-term clinical trial conducted by cancer researchers at Houston Methodist Hospital show that combining radiation treatment with "suicide gene therapy," a technique in which prostate cancer cells are genetically modified so they signal a patient's immune system to attack them, provides a safe and effective one-two punch against the disease. [More]
Sangamo presents Phase 2 data from two ongoing clinical trials of SB-728-T for treatment of HIV/AIDS

Sangamo presents Phase 2 data from two ongoing clinical trials of SB-728-T for treatment of HIV/AIDS

Sangamo BioSciences, Inc., the leader in therapeutic genome editing, announced the presentation of Phase 2 data from two of the Company's ongoing clinical trials (SB-728-1101 Cohort 3* and SB-728-mR-1401) of SB-728-T, which is being developed for the functional control of HIV/AIDS. [More]
High Efficiency Gene Expression with Pre-packaged Adenovirus

High Efficiency Gene Expression with Pre-packaged Adenovirus

AMSBIO has launched a comprehensive collection of pre-packaged human full-length cDNA ORF and miRNA adenoviruses. [More]
Clinical study shows new Ebola vaccine stimulates strong immune responses in adults

Clinical study shows new Ebola vaccine stimulates strong immune responses in adults

A clinical trial of a new Ebola vaccine (ChAd3-EBO-Z) that resulted from an unprecedented global consortium assembled at the behest of the World Health Organization has found that it is well tolerated and stimulates strong immune responses in adults in Mali, West Africa and in the US, according to a study published in the latest issue of the journal Lancet Infectious Disease. [More]
Scalable production of gene therapy vectors: an interview with Frank Ubags

Scalable production of gene therapy vectors: an interview with Frank Ubags

Gene therapy involves introducing genetic material into cells to replace missing or malfunctioning genes or to add a gene to express a beneficial protein in order to treat certain diseases, such as cancer or inherited disorders. [More]
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