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Study explores mechanism behind liraglutide-associated weight loss in obese individuals

A new study suggests that liraglutide is associated with the normalization of associative learning in obese individuals with insulin resistance.

22 Aug 2023

New microneedles could monitor melanoma therapy response

Patients with melanoma, the most concerning form of skin cancer in which pigment-producing cells start to grow out of control, can benefit from existing immunotherapies, but by far not all of them do.

21 Aug 2023

Obesity impairs brain's ability to learn associations

To control our behavior, the brain must be able to form associations. This involves, for example, associating a neutral external stimulus with a consequence following the stimulus (e.g., the hotplate glows red - you can burn your hand).

17 Aug 2023

Study: 93 million U.S. adults may benefit from semaglutide medication

Researchers from the University of California, Irvine have just published a study that projects 93 million U.S. adults that are overweight and obese may be suitable for the 2.4 mg dosage of semaglutide, a weight loss medication known under the brand name Wegovy.

16 Aug 2023

Unveiling α1-AR secrets: breakthrough structures and targeted drug design

Researchers explored the structural basis of agonist specificity of α1A-adrenergic receptors (α1-ARs).

14 Aug 2023

Illustrating the safety of a new drug treatment designed for spinal cord injury

New orally available drug for spinal cord injury found to be safe and tolerable in healthy participants.

11 Aug 2023

Revolutionizing type 2 diabetes treatment: personalized approach shows promise in matching patients with optimal glucose-lowering therapies

A personalized therapy selection algorithm for two diabetes type 2 (T2D) treatment drug classes.

10 Aug 2023

Surprising new role for a key immune regulator revealed

A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

3 Aug 2023

Intranasally administered SARS-CoV-2 RBD-based nanoparticle vaccine provides protection against lung pathology and viral load

In a recent study, researchers working at Ohio State University in the United States of America (USA) developed an intranasal subunit vaccine.

2 Aug 2023

SARS-CoV-2 spike pseudovirion infection in ARPE-19 cells is a dynamin-dependent process that is primarily mediated by LDLR

Researchers reported on lentiviral pseudovirions pseudotyped with SARS-CoV-2.

1 Aug 2023

Cryo-EM study elucidates 3D structure and molecular mechanism of platelet drug transporter

A research team led by Prof. CHEN Yuxing and Prof. ZHOU Cong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) recently utilized single-particle cryogenic electron microscopy (cryo-EM) to decipher the 3D structure and molecular mechanism of the platelet drug transporter ABCC4.

28 Jul 2023

Primary cilia play a critical role in growth plate regeneration

Growth plates (GP), situated at the ends of long bones in children, supply chondrocytes necessary for bone growth.

25 Jul 2023

Advancing vaccine adjuvants: exploring cutting-edge platforms for improved immunization

A group of authors summarized adjuvant mechanisms, characteristics, and applications, seeking to overcome current vaccine limitations.

21 Jul 2023

High body temperature may boost gut microbiota to fight viral infections

Researchers from The University of Tokyo unravel the connection between high body temperature and increased viral resistance.

20 Jul 2023

New brain-penetrant agonist shows promise in protecting dopamine neurons for Parkinson's disease treatment

Researchers reported on Nurr1 as a promising therapeutic target for managing Parkinson's disease (PD).

20 Jul 2023

Epigenetic formatting of satiety gene may increase risk of obesity in women

What determines whether we become overweight? Aside from lifestyle, predisposition plays a role, but genes cannot fully explain the inherited propensity to accumulate excess weight.

19 Jul 2023

Three-pronged combination immunotherapy shows promise for pancreatic cancer patients

Giving patients with operable pancreatic cancers a three-pronged combination immunotherapy treatment consisting of the pancreatic cancer vaccine GVAX, the immune checkpoint therapy nivolumab and urelemab, an anti-CD137 agonist antibody treatment, is safe, it increases the amount of cancer-killing immune system T cells in the tumors and it appears effective when given two weeks prior to cancer-removal surgery, according to new research directed by Johns Hopkins investigators.

17 Jul 2023

Stable nanoparticles train the immune system to fight cancer

Over the past decade, researchers have sought more effective and enduring cancer treatments. Among the wide variety of immunotherapies, Stimulator of Interfron Genes activation (STING agonism) has emerged as a particularly promising approach that harnesses a patient’s immune system to combat tumors throughout the body.

17 Jul 2023

The American Journal of Health Economics articles examine policies to address opioid crisis

The August 2023 issue of the American Journal of Health Economics will feature a cluster of articles that examine the opioid crisis.

10 Jul 2023

Research establishes ERβ as a tumor suppressor in inflammatory breast cancer

A new editorial paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "ERβ as a mediator of estrogen signaling in inflammatory breast cancer."

3 Jul 2023