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Non-invasively measuring liver stiffness with transient elastography accurately identifies advanced liver disease without biopsy

Non-invasively measuring liver stiffness with transient elastography accurately diagnoses patients with late-stage liver disease, reports a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute.

1 Sep 2008

Hypertension all about what you eat and drink

Scientific research on human metabolism based on people from around the world has revealed compounds in urine indicate surprising differences affecting blood pressure.

20 Apr 2008

Elevated liver enzymes associated with higher future mortality

A new population-based epidemiological study has found that elevated liver enzymes discovered during routine medical care are associated with higher future mortality.

4 Mar 2008

Scientists identify proteins that help bacteria put up a fight

Scientists have identified the role of two proteins that contribute to disease-causing bacteria cells' versatility in resisting certain classes of antibiotics.

27 Feb 2008

Fast food and no exercise damages the liver

Too much fast food and too little exercise can harm the liver, reveals a small study published ahead of print in the journal Gut.

18 Feb 2008

Scientists discover remarkable editing system for protein production

Even small mistakes made by cells during protein production can have profound disease effects, but the processes cells use to correct mistakes have been challenging to decipher.

4 Jan 2008

Greater need for education regarding blood borne viruses

A new cohort study could facilitate targeted interventions for adolescent offenders who are at a high risk of hepatitis C (HCV) infection and obesity related liver disease.

10 Dec 2007

New upper limit defined for normal ALT in adolescent males

A new cohort study of adolescent offenders in Australia has identified an upper limit for alanine aminotransferase (ALT) that is more sensitive for the diagnosis of liver disease.

4 Dec 2007

Phase 3 study on novel oral direct thrombin inhibitor

Boehringer Ingelheim has announced that the September 15 issue of The Lancet will publish results from the RE-NOVATE study, which investigated dabigatran etexilate as a potential therapy for patients undergoing total hip replacement surgery.

13 Sep 2007

Rosuvastatin well tolerated by a broad range of patients with dyslipidemia

The safety and tolerability of rosuvastatin were assessed using data from 16,876 patients who received rosuvastatin 5-40 mg in a multinational phase II/III/IIIb/IV program, representing 25,670 patient-years of continuous exposure to rosuvastatin. An integrated database, consisting of 33 trials whose databases were locked up to and including September 16, 2005, was used to examine adverse events and laboratory data.

9 May 2007

Researchers discover factor that controls blood sugar's manufacture in a novel way

Researchers have discovered a factor that controls blood sugar's manufacture in a novel way: by limiting the supply of its building blocks. The findings are reported in the April issue of the journal Cell Metabolism, published by Cell Press.

3 Apr 2007

Antipodean Pharma commences phase 2 trial in hepatitis C

Antipodean Pharmaceuticals has announced it has initiated a Phase 2 clinical trial of its lead compound MitoQ (mitoquinone) to investigate the drug's efficacy to reduce liver damage in patients with raised liver enzymes associated with the Hepatitis C virus (HCV).

5 Feb 2007

Biomimetic amplification of nanoparticle homing to tumors

A collaborative, multidisciplinary team of researchers has created nanoparticles that act much like a developing clot to target tumors.

16 Jan 2007

Safety of popular painkiller Tylenol questioned

According to a new study the popular painkiller Tylenol may not be as safe to take as previously thought.

5 Jul 2006

Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the U.S.

A new study on the relationship between nonalcoholic fatty liver disease (NAFLD) and heart disease found that patients with an elevated level of the enzyme associated with NAFLD had an increased risk of coronary heart disease, which appears to be related to insulin resistance, obesity and central fat distribution.

3 May 2006

GeneDesign speeds design of artificial pieces of DNA

Johns Hopkins researchers have announced the development of a Web-based, automated computer program that they say greatly simplifies the time-consuming and error-prone process of manually designing artificial pieces of DNA.

17 Feb 2006

Histidine may be key to new therapies for cardiovascular disease

It's just one little amino acid, but it makes all the difference in protecting the heart from the harmful effects of heart attack and cardiac failure. Researchers from the University of Michigan Medical School suggest this amino acid, called histidine, could be the key to a new therapy for cardiovascular disease

23 Jan 2006

Study shows that high-fat diets correlate to a chronic inflammatory state in the liver,

Mice that were fed diets high in fat and sugar developed immune system abnormalities in their livers, including reduced numbers of natural killer T (NKT) cells. These diet-related changes may contribute to obesity-related liver disease, according to a new study.

3 Oct 2005

African-American women with mitochondrial DNA variant are at increased risk of breast cancer

African-American women who carry the 10398A mitochondrial DNA allele are 60 percent more likely to develop invasive breast cancer than African-American females without that genetic marker, according to research published in the September 1 issue of "Cancer Research."

1 Sep 2005

Acetaminophen, when taken as directed, is safe for patients with liver disease

Contrary to common perception, clinical data demonstrate that acetaminophen is an appropriate pain relief choice for patients with chronic liver disease. According to a systematic literature review of the data, which is published in the current issue of the American Journal of Therapeutics, there is no evidence that acetaminophen at therapeutic doses aggravates liver disease.

26 Jul 2005