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Exposure to elevated levels of steroid hormones in the womb linked to later development of autism

Exposure to elevated levels of steroid hormones in the womb linked to later development of autism

Scientists from the University of Cambridge and the Statens Serum Institute in Copenhagen, Denmark have discovered that children who later develop autism are exposed to elevated levels of steroid hormones (for example testosterone, progesterone and cortisol) in the womb. The finding may help explain why autism is more common in males than females, but should not be used to screen for the condition. [More]
cfDNA testing lowers false positive rates and higher predictive values in general obstetric population

cfDNA testing lowers false positive rates and higher predictive values in general obstetric population

A study in this week's New England Journal of Medicine potentially has significant implications for prenatal testing for major fetal chromosome abnormalities. The study found that in a head-to-head comparison of noninvasive prenatal testing using cell free DNA (cfDNA) to standard screening methods, cfDNA testing (verifi- prenatal test, Illumina, Inc.) significantly reduced the rate of false positive results and had significantly higher positive predictive values for the detection of fetal trisomies 21 and 18. [More]
Study: Noninvasive prenatal testing detects 83.2% of chromosomal abnormalities

Study: Noninvasive prenatal testing detects 83.2% of chromosomal abnormalities

In a study to be presented on Feb. 6 at 9 a.m. CST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting-, in New Orleans, researchers will report that noninvasive prenatal testing detected 83.2 percent of chromosomal abnormalities normally picked up by invasive diagnostic testing strategies, such as chorionic villus sampling (CVS) or amniocentesis. [More]
Global NIPT market to reach USD 3.62 billion in 2019

Global NIPT market to reach USD 3.62 billion in 2019

According to a new market report published by Transparency Market Research, "Non-Invasive Prenatal Testing Market (MaterniT21 PLUS, verifi, Harmony, Panorama, NIFTY, PrenaTest and BambniTest) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019," the global NIPT market was valued at USD 0.22 billion in 2012 and is expected to grow at a CAGR of 37.6% from 2013 to 2019, to reach an estimated value of USD 3.62 billion in 2019. [More]
LUHS offers highly accurate prenatal test to determine chromosomal abnormalities in fetus

LUHS offers highly accurate prenatal test to determine chromosomal abnormalities in fetus

Loyola University Health System (LUHS) now offers chorionic villus sampling (CVS), a highly accurate prenatal test for chromosomal abnormalities in the fetus. Loyola is one of the few centers in the Chicago area to offer CVS. [More]
Study: Clinicians' decision making could be affected by method of conception

Study: Clinicians' decision making could be affected by method of conception

Parents who conceive through assisted reproductive technologies are likely to receive different medical advice in relation to prenatal testing than those who conceive naturally, academics have suggested. [More]
Studies suggest infusion of blood vessel cells may contribute to organ regeneration in future

Studies suggest infusion of blood vessel cells may contribute to organ regeneration in future

Damaged or diseased organs may someday be healed with an injection of blood vessel cells, eliminating the need for donated organs and transplants, according to scientists at Weill Cornell Medical College. [More]
BGI Health to introduce NIFTY screening test to reduce miscarriages

BGI Health to introduce NIFTY screening test to reduce miscarriages

BGI Health is marking Baby Loss Awareness Week (9-15 October) with the launch of a new non-invasive screening test for Down’s Syndrome and other conditions, which can reduce the risk of miscarriage significantly compared with other, potentially unnecessary invasive procedures, according to recent studies. [More]
Clinical study to investigate effects of prenatal chromosomal abnormalities through microarray analysis

Clinical study to investigate effects of prenatal chromosomal abnormalities through microarray analysis

Reproductive genetics researchers at Columbia University Medical Center (CUMC) are leading a multicenter prospective clinical study investigating the effects of chromosomal abnormalities (duplicative or missing material) found prenatally through microarray analysis. [More]
Study: Non-invasive blood test could reshape standards in prenatal testing

Study: Non-invasive blood test could reshape standards in prenatal testing

New research has found that routine screening using a non-invasive test that analyzes fetal DNA in a pregnant woman's blood can accurately detect Down's syndrome and other genetic fetal abnormalities in the first trimester. Published early online in Ultrasound in Obstetrics & Gynecology, the results suggest that the test is superior to currently available screening strategies and could reshape standards in prenatal testing. [More]
Verinata Health provides follow-up data on Verifi prenatal test

Verinata Health provides follow-up data on Verifi prenatal test

Illumina, Inc. today announced that Verinata Health, an Illumina company, has published the first peer-reviewed study of non-invasive prenatal test (NIPT) performance in a clinical laboratory setting. [More]
New ACMG statement on Noninvasive Prenatal Screening for Fetal Aneuploidy

New ACMG statement on Noninvasive Prenatal Screening for Fetal Aneuploidy

The American College of Medical Genetics and Genomics has just released an important new Policy Statement on "Noninvasive Prenatal Screening for Fetal Aneuploidy." [More]
Non-invasive prenatal genetic screening: an interview with Dr. Charles Strom, Senior Medical Director, Quest Diagnostics

Non-invasive prenatal genetic screening: an interview with Dr. Charles Strom, Senior Medical Director, Quest Diagnostics

A new category of non-invasive genetic screening tests is gaining a great deal of interest in the medical field – including from Quest Diagnostics -- for its potential to help screen women during pregnancy for genetic abnormalities known as trisomies, the most common of which is Down syndrome. [More]
Study shows effects of maternal obesity on fetuses

Study shows effects of maternal obesity on fetuses

In a study to be presented on February 15 between 8 a.m. and 10 a.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting -, in San Francisco, California, researchers from Tufts Medical Center will present findings showing the effects of maternal obesity on a fetus, specifically in the development of the brain. [More]
Sequencing-based test effectively detects many fetal genetic defects

Sequencing-based test effectively detects many fetal genetic defects

Researchers have developed a new screening test that allows detection of fetal abnormalities in maternal blood by deep sequencing cell-free DNA extracted from plasma. [More]

Microarray analysis ‘best test for prenatal diagnosis’

Chromosomal microarray analysis is able to identify significantly more clinically relevant information for prenatal diagnosis than is karyotyping, and is equally able to highlight aneuploidies and unbalanced rearrangements, US study findings suggest. [More]
New prenatal genetic test results in more clinically relevant information

New prenatal genetic test results in more clinically relevant information

A large, multi-center clinical trial led by researchers from Columbia University Medical Center (CUMC) shows that a new genetic test resulted in significantly more clinically relevant information than the current standard method of prenatal testing. [More]
Vascular cell generation could be used to treat vascular disorders

Vascular cell generation could be used to treat vascular disorders

A study in mice has shown that large numbers of vascular endothelial cells can be generated from human amniotic fluid-derived cells. [More]
Reprogrammed vascular endothelial cells from ACs shows promise against vascular disorders

Reprogrammed vascular endothelial cells from ACs shows promise against vascular disorders

A new approach for generating large numbers of circulatory system cells, known as vascular endothelial cells (VECs), from human amniotic-fluid-derived cells (ACs) is reported in a study published by Cell Press October 18th in the journal Cell. The strategy, which shows promise in mice, opens the door to establishing a vast inventory of VECs for promoting organ regeneration and treating diverse vascular disorders. [More]
Reprogrammed endothelial cells for treatment of vascular disorders

Reprogrammed endothelial cells for treatment of vascular disorders

A research team at Weill Cornell Medical College has discovered a way to utilize diagnostic prenatal amniocentesis cells, reprogramming them into abundant and stable endothelial cells capable of regenerating damaged blood vessels and repairing injured organs. [More]