Amyotrophic Lateral Sclerosis News and Research

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Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia

Most people with a rare type of dementia called primary progressive aphasia (PPA) have a specific combination of prion gene variants, a new study shows.

28 Nov 2005

Gene therapy and exercise may help sufferers of Lou Gehrig's disease

A new study in mice gives hope that a combination of gene therapy and exercise may extend the lives of people who have Lou Gehrig's disease.

15 Nov 2005

Northwestern University move closer to new therapies for neurodegenerative disease

French neurologist Jean-Martin Charcot first described amyotrophic lateral sclerosis (ALS) in 1869, but, nearly 140 years later, little is known about the cause of the devastating neurodegenerative disease, and there is no cure.

27 Oct 2005

Discovery could lead to tests for the clinic or battlefield to diagnose ailments with just a few drops of blood

A way to detect fragments of broken brain cells that leak into the bloodstream may help doctors more quickly and precisely treat people with severe head injuries or brain diseases, say researchers at the University of Florida's McKnight Brain Institute.

17 Oct 2005

CytRx granted "Fast Track" designation for ALS drug

CytRx Corporation today announced that the U.S. Food and Drug Administration (FDA) has granted "Fast Track" designation for the company's leading drug candidate arimoclomol for the treatment of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease).

26 Sep 2005

Study points to link to neurodegenerative disease target

A University of California - San Francisco (UCSF) study has found that a specific signaling link between neurons and muscles in the fruit fly is essential for keeping the insect's nervous system stable.

1 Sep 2005

African-American women with mitochondrial DNA variant are at increased risk of breast cancer

African-American women who carry the 10398A mitochondrial DNA allele are 60 percent more likely to develop invasive breast cancer than African-American females without that genetic marker, according to research published in the September 1 issue of "Cancer Research."

1 Sep 2005

New study points to new treatments for some forms of Lou Gehrig's disease

A new study indicates that mutant Cu/Zn superoxide dismutase (SOD1) enzymes that are associated with an inherited form of Lou Gehrig's disease cause the protein to become sticky in tissues. Partial unfolding of the mutant protein can expose hydrophobic residues that may promote abnormal interactions with other proteins or membranes in the cell.

11 Aug 2005

Riluzole appears to have significant antiobsessional, antidepressant, and antianxiety properties

A medication used to ease symptoms of amyotrophic lateral sclerosis, or Lou Gehrig's disease, also is helpful in treating people with treatment-resistant obsessive-compulsive disorder (OCD), according to a pilot study at Yale School of Medicine.

31 Jul 2005

Most people with amyotrophic lateral sclerosis (ALS) are not depressed

Contrary to what you might think, most people with amyotrophic lateral sclerosis (ALS) are not depressed. They are also not more likely to get depressed as the end of life approaches, and they are not more likely to be depressed if they want to die or hasten their own death.

11 Jul 2005

Researchers have discovered a key regulatory molecule for Huntington's disease

Researchers have discovered a key regulatory molecule whose overactivation by the abnormal protein produced in Huntington's disease (HD) causes the central pathologies of the disease.

6 Jul 2005

Columbia University launches multi-year campaign to support stem cell researc

Columbia University Medical Center (CUMC) has announced that it is halfway toward realizing the first phase of a multi-year campaign to build upon the university’s groundbreaking stem cell research and lead the effort to fully realize the therapeutic potential of stem cells.

16 Jun 2005

Diagnostic test for Lou Gehrig's disease

Bowser is director of the ALS Tissue Bank and an Associate Professor of Pathology at the University of Pittsburgh School of Medicine who is using a key piece of biomarker discovery equipment known as SELDI to find new ways to identify and eventually treat Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease.

1 Jun 2005

High-dose Tamoxifen may prolong survival in amyotrophic lateral sclerosis (ALS)

Neurologist Benjamin Brooks, who directs the MDA ALS Center at the University of Wisconsin-Madison, presented results of a trial of tamoxifen, a drug approved for the treatment of breast cancer, at a meeting of the American Academy of Neurology in April. The trial was supported in part by MDA.

23 May 2005

Antibiotic minocycline might help alleviate HIV's negative effects on the brain and central nervous system

By studying animals, Johns Hopkins researchers have discovered that the antibiotic minocycline might help alleviate HIV's negative effects on the brain and central nervous system, problems that can develop even though antiretroviral therapy controls the virus elsewhere in the body.

1 May 2005

Researchers insert engineered human stem cells into the spinal cords of ALS-afflicted rats

Unveiling a delivery method that may one day help surgeons treat the deadly neurodegenerative disease amyotrophic lateral sclerosis (ALS), researchers at the University of Wisconsin-Madison have inserted engineered human stem cells into the spinal cords of ALS-afflicted rats.

19 Apr 2005

Researchers have identified the proteins that allow specific brain cells to "change channels"

Johns Hopkins researchers have identified the proteins that allow specific brain cells to "change channels," a rare ability that tweaks what can come into the cell. The findings, described in the March 24 issue of Neuron, might let researchers harness the process, perhaps one day using it to protect cells that die in Lou Gehrig's disease.

28 Mar 2005

Gene therapy helps Lou Gehrig's disease

The most common form of motor neurone disease, called amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease, is caused when neurones in the spinal cord die, leading to muscle wasting and total paralysis.

14 Mar 2005

Finding points towards the possibility of retrovirus involvement in ALS (amyotrophic lateral sclerosis)

A significant proportion of patients suffering from ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease or motor neuron disease, have a marker of retrovirus activity in their blood, reports the February 8 issue of the medical journal Neurology.

7 Feb 2005

Scientists have coaxed human embryonic stem cells to become spinal motor neurons

After years of trial and error, scientists have coaxed human embryonic stem cells to become spinal motor neurons, critical nervous system pathways that relay messages from the brain to the rest of the body.

30 Jan 2005