Amyotrophic Lateral Sclerosis (ALS) News and Research

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Scientists unlock crucial molecular details regarding tau's activity

Frontotemporal lobar degeneration (FTLD) is a type of dementia that appears earlier in life than Alzheimer's disease (AD).

15 Sep 2020

Investigational drug may reduce protein buildup and neurological decline linked to ALS, FTD

An investigational drug that targets an instigator of the TDP-43 protein, a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), may reduce the protein's buildup and neurological decline associated with these disorders, suggests a pre-clinical study from researchers at Penn Medicine and Mayo Clinic.

8 Sep 2020

Experimental drug for ALS shows promising results in clinical trial

An experimental medication slows the progression of the neurodegenerative disease called Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to recently released results from a clinical trial run by investigators at the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital and Amylyx Pharmaceuticals, Inc., the company that manufactures the medication.

2 Sep 2020

Honeybee venom induces cancer cell death in aggressive breast cancer

The new study, published in the journal Nature Precision Oncology, highlights how bees can help combat breast cancer. The research team found that when the venom’s main component, when mixed with existing chemotherapy drugs, reduced tumor growth in laboratory mice.

2 Sep 2020

Scientists find promising drug candidates for treatment of motor neurone disease

Scientists have taken a significant step forward in the search to find effective new drug candidates for the treatment of motor neurone disease.

1 Sep 2020

Inhibiting STING activation could be new therapeutic strategy to treat ALS and FTD

Alberto Yáñez Boyer, Ramón y Cajal researcher at BIOTECMED (Interdisciplinary Research Structure in Biotechnology and Biomedicine) and the Department of Microbiology and Ecology at the University of Valencia (UV), participates in a study on the C9orf72 gene and its mutations in the immune system.

28 Aug 2020

Combining expertise in organoids and sequencing technologies for ALS research

MDC researchers received a $150,000 pilot project grant from the Chan Zuckerberg Initiative's Neurodegeneration Challenge Network to investigate a defining feature of amyotrophic lateral sclerosis (ALS).

20 Aug 2020

New treatment approach strengthens motor function and muscle of aged mice

In an aging society, one of the most important and urgent tasks of scientific research is to counteract the decline in motor function and muscle weakness that accompanies the aging process.

17 Aug 2020

Purdue University startup receives NIH grant to advance Alzheimer's research

A $2 million grant from the National Institute on Aging at the National Institutes of Health to Neurodon, a Purdue University-affiliated startup, will help fast-track molecules that could improve memory and reduce Alzheimer's disease neurodegeneration.

12 Aug 2020

New technology could serve as more reliable model of amyotrophic lateral sclerosis

A new study published today demonstrates that a technology developed at the University of Central Florida could serve as a more reliable clinically-based model of amyotrophic lateral sclerosis (ALS) and a better screening tool for novel therapies than currently use preclinical models.

12 Aug 2020

Implantable brain-computer interface shows promise to improve function in paralyzed patients

Researchers demonstrated the success of a fully implantable wireless medical device called a stentrode brain-computer interface designed to improve functional independence in patients with severe paralysis.

6 Aug 2020

C-Path gets positive response from FDA for drug-induced skeletal muscle injury safety biomarkers

Critical Path Institute announced today that the Biomarker Qualification Program at the Center for Drug Evaluation and Research in the U.S. Food and Drug Administration issued a positive response to the Letter of Intent developed by C-Path's Predictive Safety Testing Consortium and Duchenne Regulatory Science Consortium, for a panel of four safety biomarkers of acute drug-induced skeletal muscle injury.

23 Jul 2020

Yale researchers uncover potential treatment for lethal Wolfram Syndrome

Yale pharmacology professor Barbara Ehrlich and her team have uncovered a mechanism driving a rare, lethal disease called Wolfram Syndrome and also a potential treatment. Their findings appear in the July 6 edition of Proceedings of the National Academy of Sciences.

16 Jul 2020

Salmonella biofilm protein can cause autoimmune responses, arthritis in animals

Scientists from the Vaccine and Infectious Disease Organization-International Vaccine Centre at the University of Saskatchewan and Temple University have demonstrated that a Salmonella biofilm protein can cause autoimmune responses and arthritis in animals.

10 Jul 2020

Experimental drug for rare ALS shows promise in early clinical trial

An experimental drug for a rare, inherited form of amyotrophic lateral sclerosis (ALS) has shown promise in a phase 1/phase 2 clinical trial conducted at Washington University School of Medicine in St. Louis, Massachusetts General Hospital in Boston and other sites around the world and sponsored by the pharmaceutical company Biogen Inc.

8 Jul 2020

Researchers identify new molecules to study specific glial cells integral to synapses

While the brain is composed of two types of cells, glia tend to receive far less attention for their importance in brain function and disease than the more celebrated neurons.

26 Jun 2020

Study reveals new insight into Fuchs’ endothelial corneal dystrophy

The molecular changes that lead to Fuchs' endothelial corneal dystrophy (FECD) occur decades before the disease causes blurry vision and other noticeable symptoms in patients, new research by UT Southwestern scientists shows.

17 Jun 2020

Discovery could significantly improve diagnosis of motor neuron disease

Scientists at the University of Sussex have identified a potential pattern within blood which signals the presence of motor neuron disease; a discovery which could significantly improve diagnosis.

17 Jun 2020

Link between ALS and Alzheimer's disease can help advance the search for new therapies

On the surface, amyotrophic lateral sclerosis (ALS) and Alzheimer's disease share two commonalities: Both are progressively debilitating neurodegenerative conditions--meaning symptoms get worse--and, at least for now, neither has an effective treatment, let alone a cure.

16 Jun 2020

UMSOM researchers identify how certain gene mutations cause ALS

Researchers at the University of Maryland School of Medicine have identified how certain gene mutations cause amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.

10 Jun 2020