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Male hormones can reverse biological drivers of aging, study shows

Male hormones can reverse biological drivers of aging, study shows

Telomerase, an enzyme naturally found in the human organism, is the closest of all known substances to a "cellular elixir of youth." In a recent study, Brazilian and US researchers show that sex hormones can stimulate production of this enzyme. [More]
New imaging tool may help detect presence of androgen receptor in prostate cancer patients

New imaging tool may help detect presence of androgen receptor in prostate cancer patients

Prostate cancer is one of the most common cancers in men. Tumor growth is critically regulated by the androgen receptor, and treatment strategies to lower androgens, such as testosterone, are a mainstay of clinical treatment. [More]
Study finds evidence that PD-1 antibody may benefit men with metastatic prostate cancer

Study finds evidence that PD-1 antibody may benefit men with metastatic prostate cancer

Restoring tumor-specific immunity is a treatment strategy that works well in melanoma and lung cancer patients. Now a new study out of the OHSU Knight Cancer Institute is reviving hope that the approach also may help men with life-threatening prostate cancer. [More]
Chromatrap reports benefits of ChIP technology in ground breaking research

Chromatrap reports benefits of ChIP technology in ground breaking research

Chromatrap reports on 3 further customer papers published in different prestigious peer reviewed journals, which cite how its proprietary solid state Chromatin Immunoprecipitation (ChIP) technology has enabled ground breaking research. [More]
Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

“IDPs” is now a widely used acronym that stands for “intrinsically disordered proteins.” It is the term generally used by the scientific community to refer to a wide variety of proteins that do not have a stable 3D structure and are instead characterized by a high extent of local mobility, disorder and many conformers that are accessible at room temperature. [More]
Testosterone therapy improves sexual activity in older men

Testosterone therapy improves sexual activity in older men

Older men with low libido and low testosterone levels showed more interest in sex and engaged in more sexual activity when they underwent testosterone therapy, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. [More]
KIT researchers develop 3D prostate model based on cryogels

KIT researchers develop 3D prostate model based on cryogels

A team of researchers led by Dr. Friederike J. Gruhl and Professor Andrew C. B. Cato at Karlsruhe Institute of Technology are developing a three-dimensional model for prostate cancer research based on cryogels. [More]
New research offers more insights into development of Kennedy's disease

New research offers more insights into development of Kennedy's disease

Kennedy's disease leads to progressive muscle wastage. It is a condition that affects only men and it appears between 40 and 50 years of age. There is no specific treatment available. [More]
Metabolic characteristics of CRPC may open new avenues for treatment

Metabolic characteristics of CRPC may open new avenues for treatment

Advanced prostate cancer is usually treated by removing androgen, the male hormone that helps it grow. Although initially effective, this treatment often leads to the tumor becoming castration resistant- a lethal condition. [More]
Vitamin D and androgen receptor-targeted therapy may help treat TNBC

Vitamin D and androgen receptor-targeted therapy may help treat TNBC

A recent study by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine revealed that triple-negative breast cancer (TNBC), which has generally been unresponsive to hormone receptor-targeted treatments, can indeed be treated using vitamin D and androgen receptor-targeted therapy. [More]
AKR1C3 enzyme could be promising therapeutic target for managing CRPC, AML

AKR1C3 enzyme could be promising therapeutic target for managing CRPC, AML

Prostate cancer is the second leading cause of mortality among American men with the highest incidence rate of all cancers reported in the U.S. Male sex hormones testosterone (T) and 5α-dihydrotestosterone (5α-DHT) promote prostate cancer progression. [More]
Genomic cfDNA profiling feasible in metastatic CRPC

Genomic cfDNA profiling feasible in metastatic CRPC

Comprehensive genomic profiling of cell-free DNA can provide clinically useful information in men with castration-resistant prostate cancer treated with enzalutamide, research indicates. [More]
Hsp90 inhibitors could be effective in treating drug-resistant prostate cancers

Hsp90 inhibitors could be effective in treating drug-resistant prostate cancers

Men with aggressive prostate cancer that has stopped responding to conventional treatment could potentially benefit from a new class of cancer drug designed to overcome drug resistance, a new study suggests. [More]
Study helps discover new treatments for type 2 diabetes in men with low testosterone

Study helps discover new treatments for type 2 diabetes in men with low testosterone

Doctors have long known that men with low testosterone are at greater risk for developing type 2 diabetes. For the first time, researchers have identified how testosterone helps men regulate blood sugar by triggering key signaling mechanisms in islets, clusters of cells within the pancreas that produce insulin. The findings, co-authored by Tulane University researchers, are published in the journal [More]
Testosterone may lead to greater heart attack risk in men than women

Testosterone may lead to greater heart attack risk in men than women

Testosterone might be involved in explaining why men have a greater risk of heart attacks than women of similar age, according to a study funded by the British Heart Foundation and the Biotechnology and Biological Sciences Research Council. The findings, published in the journal Scientific Reports, could lead to new therapies to help reduce heart attack risk. [More]
MAILES study finds link between fatty diets and sleep

MAILES study finds link between fatty diets and sleep

University of Adelaide researchers have found that men who consume diets high in fat are more likely to feel sleepy during the day, to report sleep problems at night, and are also more likely to suffer from sleep apnea. [More]
Older men receiving testosterone therapy less likely to return to hospital

Older men receiving testosterone therapy less likely to return to hospital

A new large-scale population-based study from The University of Texas Medical Branch at Galveston showed for the first time that older men using testosterone therapy were less likely to have complications that require them to go back to the hospital within a month of being discharged than men not using this therapy. The study is currently available in Mayo Clinic Proceedings. [More]
Cholesterol-fighting drug molecule can kill prostate cancer cells

Cholesterol-fighting drug molecule can kill prostate cancer cells

Standard treatment for prostate cancer can include chemotherapy that targets receptors on cancer cells. However, drug-resistant cancer cells can emerge during chemotherapy, limiting its effectiveness as a cancer-fighting agent. Researchers at the University of Missouri have proven that a compound initially developed as a cholesterol-fighting molecule not only halts the progression of prostate cancer, but also can kill cancerous cells. [More]
Infant daughters may show early signs of PCOS from mothers

Infant daughters may show early signs of PCOS from mothers

The infant daughters of women with polycystic ovary syndrome (PCOS) show a higher level of an enzyme that activates testosterone and may be an early sign of developing the complex genetic disease, according to a new Northwestern Medicine study. [More]
Testosterone therapy helps reduce risk of adverse cardiovascular events in elderly men

Testosterone therapy helps reduce risk of adverse cardiovascular events in elderly men

A new multi-year study from the Intermountain Medical Center Heart Institute in Salt Lake City shows that testosterone therapy helped elderly men with low testosterone levels and pre-existing coronary artery disease reduce their risks of major adverse cardiovascular events — including strokes, heart attacks, and death. [More]
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