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Anemia is a decrease in normal number of red blood cells (RBCs) or less than the normal quantity of hemoglobin in the blood. However, it can include decreased oxygen-binding ability of each hemoglobin molecule due to deformity or lack in numerical development as in some other types of hemoglobin deficiency. The three main classes of anemia include excessive blood loss (acutely such as a hemorrhage or chronically through low-volume loss), excessive blood cell destruction (hemolysis) or deficient red blood cell production (ineffective hematopoiesis). Anemia is the most common disorder of the blood. There are several kinds of anemia, produced by a variety of underlying causes. Anemia can be classified in a variety of ways, based on the morphology of RBCs, underlying etiologic mechanisms, and discernible clinical spectra, to mention a few.
Special article outlines recommended strategies to prevent Zika from blood transfusion

Special article outlines recommended strategies to prevent Zika from blood transfusion

As the Zika epidemic spreads to the United States, the potential for contracting the disease via blood transfusion has emerged as a serious concern. [More]
Scientists discover molecular link between rare childhood genetic disease and major cancer gene

Scientists discover molecular link between rare childhood genetic disease and major cancer gene

A team of researchers led by a University of Rhode Island scientist has discovered an important molecular link between a rare childhood genetic disease, Fanconi anemia, and a major cancer gene called PTEN. [More]
Iron deficiency: an interview with Dr Thierry Teil

Iron deficiency: an interview with Dr Thierry Teil

Iron deficiency is, in fact, one of the most common nutritional disorders. It affects between three and five billion people, which is between half and two-thirds of the world population (about seven billion). Iron deficiency anemia is a subset of iron deficiency, that is about two billion people according to the WHO... [More]
Experts develop new method to quantify syncytial knots in placenta

Experts develop new method to quantify syncytial knots in placenta

Identifying potential risk factors that may harm placental development is a primary objective of pregnancy screenings. To help ensure healthy pregnancies and, in turn, healthy newborns, researchers and clinicians continue to develop new and innovative testing methods to monitor fetal development. [More]
UI research may help raise awareness and reduce practice of ‘rainbow draw’

UI research may help raise awareness and reduce practice of ‘rainbow draw’

University of Iowa researchers have shown that most of the extra vials of blood drawn for lab tests never get used and are instead discarded. [More]
High-altitude dwellers prone to chronic mountain sickness produce huge amounts of red blood cells

High-altitude dwellers prone to chronic mountain sickness produce huge amounts of red blood cells

To better understand why some people adapt well to life at high altitude while others don't, researchers at University of California San Diego School of Medicine studied red blood cells derived from representatives of both groups living in the Andes Mountains. [More]
FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

FDA approves expanded use of systemic therapy for treating chronic moderate-to-severe pediatric psoriasis

Amgen today announced that the U.S. Food and Drug Administration has approved the supplemental Biologics License Application for the expanded use of ENBREL (etanercept), making it the first and only systemic therapy to treat pediatric patients (ages 4-17) with chronic moderate-to-severe plaque psoriasis. [More]
Yale researchers use new gene editing technique to correct mutations that cause thalassemia

Yale researchers use new gene editing technique to correct mutations that cause thalassemia

A Yale-led research team used a new gene editing strategy to correct mutations that cause thalassemia, a form of anemia. [More]
Many ulcerative colitis patients with anemia do not receive testing and treatment, study reports

Many ulcerative colitis patients with anemia do not receive testing and treatment, study reports

Many patients with ulcerative colitis don't receive recommended testing and treatment for the common problem of iron deficiency anemia, reports a study in the October issue of Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America (CCFA). The journal is published by Wolters Kluwer. [More]
Novel ‘gene therapy in a box’ could effectively deliver modified blood stem cells

Novel ‘gene therapy in a box’ could effectively deliver modified blood stem cells

A table-top device that enables medical staff to genetically manipulate a patient's blood to deliver potential new therapies for cancer, HIV and other diseases would eliminate the need for multi-million-dollar "clean rooms," making gene therapy more possible for even the poorest of countries. [More]
Network of proteins linked to cancer may play vital role in male fertility

Network of proteins linked to cancer may play vital role in male fertility

Researchers studying reproductive science identified a network of proteins often linked to cancer as also important to male fertility and the birth of healthy offspring, according to a study in the Oct. 18 online issue of Cell Reports. [More]
EKF Diagnostics’ novel diabetic biomarker test successfully externally verified

EKF Diagnostics’ novel diabetic biomarker test successfully externally verified

EKF Diagnostics, the global in vitro diagnostics company, announces that its newly introduced Glycated Serum Protein (GSP) LiquiColor® diabetic biomarker test has been verified for use on the Siemens Vista chemistry analyzer. [More]
High folate intake may increase risk of peripheral neuropathy in older adults with common gene variant

High folate intake may increase risk of peripheral neuropathy in older adults with common gene variant

Consuming too much folate (vitamin B9) is associated with increased risk for a nerve-damage disorder in older adults who have a common genetic variant. [More]
Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

A team of physicians and laboratory scientists has taken a key step toward a cure for sickle cell disease, using CRISPR-Cas9 gene editing to fix the mutated gene responsible for the disease in stem cells from the blood of affected patients. [More]
Study finds new therapeutic target to prevent progression of rare blood cancer

Study finds new therapeutic target to prevent progression of rare blood cancer

In a laboratory study, Upstate Medical University researcher Golam Mohi, Ph.D., his graduate student Yue Yang, and colleagues, have found that the loss of gene EZH2 promotes the development of Myelofibrosis (MF) in mice. [More]
New study finds no evidence of benefit from genetic disposition of eczema

New study finds no evidence of benefit from genetic disposition of eczema

Some genetic diseases persist for generation after generation because the genes that cause them can benefit human health. [More]
Rutgers researchers aim to set blood transfusion standards for heart attack patients

Rutgers researchers aim to set blood transfusion standards for heart attack patients

A Rutgers physician who has championed the movement to use less blood in transfusions has been awarded more than $16.1 million by the National Institutes of Health National Heart, Lung, and Blood Institute to lead a nation-wide clinical trial to evaluate whether a restrictive or a liberal blood transfusion is most beneficial to patients who have had a heart attack. [More]
New mobile health app may help manage hydroxyurea treatments in sickle cell patients

New mobile health app may help manage hydroxyurea treatments in sickle cell patients

The National Heart, Lung, and Blood Institute, part of the National Institutes of Health, has awarded a 6-year, $4.4 million grant to St. Jude Children's Research Hospital and collaborators to improve the use of prescribed medication by sickle cell patients. [More]
Study compares different strategies to prevent malaria among pregnant women in sub Saharan Africa

Study compares different strategies to prevent malaria among pregnant women in sub Saharan Africa

A novel strategy to screen pregnant women for malaria with rapid diagnostic tests and treat the test-positive women with effective antimalarials does not lower the risk of adverse pregnancy outcomes compared with treating all pregnant women with the malaria preventive sulfadoxine-pyrimethamine (SP) in sub-Saharan Africa, according to an open label randomized trial published this week in PLOS Medicine by Feiko ter Kuile, of the Liverpool School of Tropical Medicine, and colleagues. [More]
Alexion initiates new global Uncommon Strength campaign to raise awareness of rare diseases

Alexion initiates new global Uncommon Strength campaign to raise awareness of rare diseases

Alexion Pharmaceuticals, Inc. today announced the launch of Uncommon Strength, a global campaign to raise awareness of rare diseases through the celebration of the extraordinary resilience and inner strength of those impacted by these diseases. [More]