Anesthetics News and Research

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Microglia found to play a key role in regulating the body's response to anesthesia

Though it may be a surprise to the millions of people who undergo general anesthesia every year for medical procedures, the biological mechanism for how different anesthetics block consciousness is still not fully understood.

22 Dec 2023

Revolutionizing pain management: Study highlights effectiveness of low-dose local anesthetics

The therapeutic efficacy of low-dose local anesthetics (LAs) in various clinical conditions, highlighting gaps in current research for future exploration.

23 Nov 2023

Scientists develop tissue adhesive gelatin hydrogels to speed up wound healing, prevent infections

Open wounds, whether caused by accidents or from medical procedures like surgery, require proper management to speed up healing and prevent infections.

6 Nov 2023

Intracellular journey: The penetration of antidepressants into cells, organelles, and membranes

Researchers in neuropsychopharmacology challenge conventional wisdom about antidepressants' actions, revealing significant intracellular activity that influences their effectiveness. Utilizing advanced technologies, the study prompts a reevaluation of drug targeting and mechanisms, opening new avenues for treating depression.

12 Oct 2023

Tracking brain wave signatures could reduce the risk of postoperative brain dysfunction

When patients undergo general anesthesia, their brain activity often slows down as they sink into unconsciousness.

17 Jul 2023

Low-level laser therapy and associated photobiomodulation is the most effective treatment for tinnitus

Low-level laser therapy and associated photobiomodulation is the most effective of the known treatments for tinnitus, according to a study comparing the main therapies in current use, conducted by Brazilian scientists affiliated with the Optics and Photonics Research Center.

21 Jun 2023

How do patients feel about postoperative cognitive dysfunction?

The current study reported the results of an analysis of comments submitted in response to an online published article on postoperative cognitive decline.

5 Mar 2023

Decreasing anesthetics during procedures without compromising patient care can reduce greenhouse gas emissions

Anesthesiologists can play a role in reducing the greenhouse gas emissions that contribute to global warming by decreasing the amount of anesthetic gas provided during procedures without compromising patient care, suggests new research being presented at the American Society of Anesthesiologists' ADVANCE 2023, the Anesthesiology Business Event.

29 Jan 2023

The risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population

Researchers evaluated the outcomes and identified risk factors associated with the development of ARDS after SARS-CoV-2 infections among young adults.

6 Jan 2023

Study shows how ketamine administration starkly changes neuronal activity patterns in the brain

Ketamine, an established anesthetic and increasingly popular antidepressant, dramatically reorganizes activity in the brain, as if a switch had been flipped on its active circuits, according to a new study by Penn Medicine researchers.

1 Dec 2022

Researchers identify best methods to study resting state of the brain in marmosets

A team led by researchers from Tokyo Metropolitan University have identified the best methods to study the resting state of the brain in marmosets using functional MRI.

21 Nov 2022

Genicular nerve blocks provide short term pain relief for patients with knee osteoarthritis

Results from a recent clinical trial published by Wiley in Arthritis & Rheumatology demonstrate that patients with knee osteoarthritis experience short term pain relief from genicular nerve blocks-;or locally injected anesthetics that block nerves around the knee joint.

13 Nov 2022

Delay in consciousness in severe cases of COVID-19 may be caused by neural hibernation

An article published in the journal PNAS provides a conceptual analysis to interpret the brain state of coronavirus disease 2019 (COVID-19) patients experiencing prolonged recovery of consciousness.

10 Nov 2022

Mouse model reveals link between GABA receptors and sleepiness in people with myotonic dystrophy

People with the inherited disorder myotonic dystrophy (DM) often experience excessive daytime sleepiness and fatigue, as well as altered responses to anesthetics that can put them at risk for complications when hospitalized.

29 Sep 2022

Optically controlled local heat-pulse method manipulates temperature in cells

A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and leads to malignant hyperthermia

8 Aug 2022

Addressing parents' hesitancy to vaccinate their children against COVID

Researchers examine notable risk factors related to vaccine hesitancy among parents.

23 Jun 2022

Women are seldom informed about contraceptive failure following common anesthetic use

Women undergoing operations are not being routinely informed that a common anesthetics may make their contraception less effective, putting them at risk of an unplanned pregnancy, new research being presented at Euroanaesthesia, the annual meeting of the European Society of Anaesthesiology and Intensive Care (ESAIC) in Milan, Italy (4-6 June), suggests.

3 Jun 2022

Researchers help better understand the neuronal mechanisms of general anesthesia

In a paper recently published in Neuron, researchers from the group of Botond Roska at IOB reveal how different cell types in cortex change their activity during general anesthesia, helping to understand how unconsciousness may be induced.

16 May 2022

Nanobodies from llamas could be used to deliver targeted medicines to human muscle cells

In "proof of concept" experiments with mouse and human cells and tissues, Johns Hopkins Medicine researchers say they have designed tiny proteins, called nanobodies, derived from llama antibodies, that could potentially be used to deliver targeted medicines to human muscle cells.

12 May 2022

At US hospitals, a drug mix-up is just a few keystrokes away

More than four years ago, Tennessee nurse RaDonda Vaught typed two letters into a hospital's computerized medication cabinet, selected the wrong drug from the search results, and gave a patient a fatal dose.

29 Apr 2022