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New biosensing platform could help determine Haptoglobin in human blood

New biosensing platform could help determine Haptoglobin in human blood

We are pleased to announce that a new biosensing platform has been fabricated for the determination of Haptoglobin in human blood. [More]
New study highlights important milestone for future development of infant milk formula

New study highlights important milestone for future development of infant milk formula

New data published today in The Journal of Nutrition show that Bimuno, a unique galacto-oligosaccharide, is functionally similar to human milk oligosaccharides (HMOS) by producing comparable anti-inflammatory intestinal protection. [More]
Sphingosine kinase inhibitor slows castration-resistant prostate cancer cell growth

Sphingosine kinase inhibitor slows castration-resistant prostate cancer cell growth

A first-in-class sphingosine kinase 2 inhibitor slowed the growth of castration-resistant prostate cancer cells, in part by inhibiting the enzyme dihydroceramide desaturase (DEGS), but did not kill them, according to the results of preclinical in vitro and in vivo studies published in the December 2015 issue of Molecular Cancer Therapeutics by researchers at the Medical University of South Carolina and others. [More]
Fingolimod trial INFORMS primary progressive MS strategy

Fingolimod trial INFORMS primary progressive MS strategy

Fingolimod is unable to slow disability progression or brain volume loss in patients with primary progressive multiple sclerosis, show the findings of the INFORMS study. [More]
Neuroprotection powers for phenytoin in acute optic neuritis

Neuroprotection powers for phenytoin in acute optic neuritis

Selective sodium channel blockade with the anti-epileptic drug phenytoin protects against acute demyelinating optic neuritis, researchers report. [More]
Neurons protect intestinal tissue from over-inflammation

Neurons protect intestinal tissue from over-inflammation

The immune system exercises constant vigilance to protect the body from external threats--including what we eat and drink. A careful balancing act plays out as digested food travels through the intestine. Immune cells must remain alert to protect against harmful pathogens like Salmonella, but their activity also needs to be tempered since an overreaction can lead to too much inflammation and permanent tissue damage. [More]
UAB study shows IL-37 protein suppresses inflammatory response after spinal cord injury

UAB study shows IL-37 protein suppresses inflammatory response after spinal cord injury

Spinal cord injuries cause severe functional disabilities in those who sustain them, including paraplegia or tetraplegia, depending on the scale of the injury. This is due to the degeneration of the spinal pathways that carry nerve signals from the brain to the different parts of the body and vice versa, resulting in loss of mobility and sensitivity underneath the injured area. [More]
Allergan announces publication of VIBERZI Phase III trial results in The New England Journal of Medicine

Allergan announces publication of VIBERZI Phase III trial results in The New England Journal of Medicine

Allergan plc announced today the publication of the positive results of the Phase III trials of VIBERZITM C IV (eluxadoline) for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in the January 21 issue of The New England Journal of Medicine. [More]
Scientists solve atomic structure of ubiquitin ligase complex that plays key role in protein degradation

Scientists solve atomic structure of ubiquitin ligase complex that plays key role in protein degradation

Scientists at Sanford Burnham Prebys Medical Discovery Institute have solved the atomic structure of a unique ubiquitin ligase complex. Ubiquitin is best known for its role in protein degradation, but more recently seen as important for cell signaling, DNA repair, anti-inflammatory, and immune responses. [More]
Study outlines new model to help predict age-related response to hepatitis B vaccine

Study outlines new model to help predict age-related response to hepatitis B vaccine

Physicians have known for years that patients respond differently to vaccines as they age. There may soon be a new way to predict and enhance the effectiveness of vaccinations, in particular the hepatitis B vaccine. [More]
GBI Research says COPD therapeutics pipeline lacks innovation

GBI Research says COPD therapeutics pipeline lacks innovation

Analysis from business intelligence provider GBI Research - Frontier Pharma: Chronic Obstructive Pulmonary Disease (COPD) - Identifying and Commercializing First-in-Class Innovation - states that while currently-available drugs aim to manage the frequency and severity of symptoms associated with COPD, none have been shown to modify long-term disease progression. [More]
Researchers confirm that cranberry extract helps fight UTIs in breastfed children under age one

Researchers confirm that cranberry extract helps fight UTIs in breastfed children under age one

Researchers from the universities of Granada (Spain) and Kvopio (Finland) have confirmed that cranberry extract helps fighting urinary tract infections (UTIs) in breastfed babies under one year of age. [More]
Using statins before and after heart surgery can help reduce cardiac complications, mortality risks

Using statins before and after heart surgery can help reduce cardiac complications, mortality risks

Using statins before and after coronary artery bypass grafting (CABG) surgery can help reduce cardiac complications, such as atrial fibrillation, following surgery and also can reduce the risk of death during and after surgery, according to a review article posted online today by The Annals of Thoracic Surgery. [More]
Inflammation associated with elevated glutamate in the brain could guide depression treatments

Inflammation associated with elevated glutamate in the brain could guide depression treatments

Psychiatrists investigating depression have been energized in recent years by reports of rapid, successful treatment with drugs that interfere with the brain chemical glutamate, such as the anesthetic ketamine. [More]
Pre-existing nutritional deficits, immune dysfunction may increase hepatitis E risk during pregnancy

Pre-existing nutritional deficits, immune dysfunction may increase hepatitis E risk during pregnancy

Researchers from the Johns Hopkins Bloomberg School of Public Health have found a link between pre-existing nutritional deficits and immune dysfunction and the risk of hepatitis E infection during pregnancy. [More]
Common painkiller diclofenac has significant anti-cancer properties

Common painkiller diclofenac has significant anti-cancer properties

Diclofenac, a common painkiller, has significant anti-cancer properties, according to researchers from the Repurposing Drugs in Oncology project. [More]
Novel anti-inflammatory agents could control hyper-inflammatory responses to fungal infection

Novel anti-inflammatory agents could control hyper-inflammatory responses to fungal infection

The most frequent fungal threat to humans, Candida albicans, is a common cause oral and genital infection. The fungal infections are often worsened by overwhelming inflammatory responses in the body and cause high mortality among risk groups. Umeå University doctoral student Ava Hosseinzadeh has discovered two novel anti-inflammatory agents, an antioxidant and an anti-inflammatory molecule, which could be used to control the hyper-inflammatory responses to the fungal infection. [More]
Low-oxygen exposure shortly after birth may increase learning and behavioral disorder risks

Low-oxygen exposure shortly after birth may increase learning and behavioral disorder risks

New research published in the Journal of Leukocyte Biology, shows that the development of white matter in the mouse brains is delayed when they are exposed to chronic low oxygen levels shortly after birth. [More]
FDA permits Sound Pharmaceuticals to start SPI-1005 clinical trial for treatment of Meniere's Disease

FDA permits Sound Pharmaceuticals to start SPI-1005 clinical trial for treatment of Meniere's Disease

Sound Pharmaceuticals is pleased to announce that it began enrolling a clinical trial to test SPI-1005 in the treatment of Meniere's Disease (MD). MD or idiopathic endolymphatic hydrops is an inner ear disease that involves episodic vertigo, sensorineural hearing loss, and tinnitus. [More]
Drug-microbe interactions may contribute to adverse effects, lessen effectiveness of NSAID

Drug-microbe interactions may contribute to adverse effects, lessen effectiveness of NSAID

A nonsteroidal anti-inflammatory drug (NSAID) changed the composition and diversity of gut microbes, which in turn shaped how the drug is broken down and ultimately, cut its effectiveness, according to an animal study from the Perelman School of Medicine at the University of Pennsylvania. [More]
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