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Antidepressants are medicines that treat depression. Your doctor can prescribe them for you. They can improve your mood, sleep, appetite and concentration. It may take several weeks for them to help. There are several types of antidepressants. You and your doctor may have to try several before finding what works best for you.
Common antidepressant can help stroke patients improve movement and coordination

Common antidepressant can help stroke patients improve movement and coordination

Working with mice, researchers at Johns Hopkins have added to evidence that a commonly prescribed antidepressant called fluoxetine helps stroke victims improve movement and coordination, and possibly why. [More]
FDA approves MagVenture MagVita TMS Therapy system for treatment of Major Depressive Disorder

FDA approves MagVenture MagVita TMS Therapy system for treatment of Major Depressive Disorder

On July 31, 2015 the US Food and Drug Administration cleared the MagVita TMS Therapy system for the treatment of Major Depressive Disorder in adult patients who have failed to receive satisfactory improvement from prior antidepressant medication in the current episode. [More]
Repetitive sacral root magnetic stimulation can reduce frequency of nighttime bedwetting

Repetitive sacral root magnetic stimulation can reduce frequency of nighttime bedwetting

Bedwetting, or nocturnal enuresis, causes distress in children and young adults, as well as for their parents or caregivers. The causes are not fully understood and there may be both physiological and psychological components to the condition. In a new study published in Restorative Neurology and Neuroscience, researchers report that repetitive sacral root magnetic stimulation (rSMS) can reduce the frequency of nighttime bedwetting and improve quality-of-life for sufferers. [More]
New prescription smoking-cessation drug not helping smokers quit

New prescription smoking-cessation drug not helping smokers quit

The introduction of a new prescription smoking-cessation aid, varenicline, in 2006 has had no significant impact on the rate at which Americans age 18 and older successfully quit smoking, according to a study led by researchers at University of California, San Diego School of Medicine. [More]
Prion protein could play a role in depression

Prion protein could play a role in depression

The discovery of antidepressant drugs in the 1950s led to the first biochemical hypothesis of depression, known as the monoamine hypothesis. This hypothesis proposes that an imbalance of certain brain chemicals is the key cause of depression. [More]
Researchers analyze inclusion/exclusion criteria used in antidepressant efficacy studies

Researchers analyze inclusion/exclusion criteria used in antidepressant efficacy studies

Mark Zimmerman, M.D., a clinical researcher at Rhode Island Hospital, and his team analyzed the criteria used in antidepressant efficacy studies (AETs) and learned that the inclusion/exclusion criteria for AETs have narrowed over the past five years so that the most patients are excluded. The research was published today in Mayo Clinic Proceedings. [More]
IQWiG dossier assessment finds no added benefit for vortioxetine in depression

IQWiG dossier assessment finds no added benefit for vortioxetine in depression

Vortioxetine (trade name: Brintellix) has been approved since December 2013 for the treatment of depression in adults, but did not become actually available before May 2015. The German Institute for Quality and Efficiency in Health Care examined in a dossier assessment whether this drug offers an added benefit over the appropriate comparator therapy. Such an added benefit cannot be derived from the dossier because it contained no data evaluable for the assessment. [More]
FDA accepts sNDA to review Brintellix clinical trial data for treatment of major depressive disorder

FDA accepts sNDA to review Brintellix clinical trial data for treatment of major depressive disorder

Takeda Pharmaceutical Company Limited (Takeda) and H. Lundbeck A/S (Lundbeck) announced today the U.S. Food and Drug Administration (FDA) has accepted a supplemental New Drug Application (sNDA) for review to add clinical data regarding the effect of Brintellix (vortioxetine) on certain aspects of cognitive function in adults with Major Depressive Disorder (MDD) to the current product label. [More]
Benefits and risks of taking antidepressant medications during pregnancy

Benefits and risks of taking antidepressant medications during pregnancy

Treating maternal psychiatric disorder with commonly used antidepressants is associated with a lower risk of certain pregnancy complications including preterm birth and delivery by Caesarean section, according to researchers at Columbia University's Mailman School of Public Health, Columbia University Medical Center, and the New York State Psychiatric Institute. However, the medications -- selective serotonin reuptake inhibitors, or SSRIs -- resulted in an increased risk of neonatal problems. [More]
Female patients with depression have abnormally high expression levels of glutamate receptor genes

Female patients with depression have abnormally high expression levels of glutamate receptor genes

Numerous genes that regulate the activity of a neurotransmitter in the brain have been found to be abundant in brain tissue of depressed females. This could be an underlying cause of the higher incidence of suicide among women, according to research at the University of Illinois at Chicago. [More]
IUPUI researchers receive NIH grant to study effect of depression treatment on cardiovascular disease

IUPUI researchers receive NIH grant to study effect of depression treatment on cardiovascular disease

Indiana University-Purdue University Indianapolis researchers led by Jesse Stewart of the School of Science, have received a $2.6 million grant from the National Institutes of Health to conduct the first randomized controlled trial to determine whether depression treatment can help prevent the development of cardiovascular disease. [More]
Psychotropic medication use widespread among older adults, new study finds

Psychotropic medication use widespread among older adults, new study finds

Older Americans receive prescriptions for mental health medications at more than twice the rate that younger adults do, a new study finds. [More]
Diagnosing psychiatric disorder may not be as important as prescribing effective treatment

Diagnosing psychiatric disorder may not be as important as prescribing effective treatment

Nailing the diagnosis of a psychiatric disorder may not be important in prescribing effective treatment, according to Mark Zimmerman, M.D., a clinical researcher at Rhode Island Hospital. His opinion editorial was published online today in the Journal of Clinical Psychiatry. [More]
Study reveals potential new therapeutic target for depression treatment

Study reveals potential new therapeutic target for depression treatment

Increasing the levels of a signaling molecule found in the brain can positively alter response to stress, revealing a potential new therapeutic target for treatment of depression, UT Southwestern Medical Center researchers said. [More]
Most patients with depression excluded from antidepressant trials, study finds

Most patients with depression excluded from antidepressant trials, study finds

More than 80 percent of people with depression in the general population aren't eligible for clinical trials of antidepressant drugs, according to a study in the Journal of Psychiatric Practice. [More]
New study identifies potential antidepressant medications with few side effects

New study identifies potential antidepressant medications with few side effects

A new study by researchers at University of Maryland School of Medicine has identified promising compounds that could successfully treat depression in less than 24 hours while minimizing side effects. Although they have not yet been tested in people, the compounds could offer significant advantages over current antidepressant medications. [More]
Research examines reasons behind variation in prescription practices of antidepressants across Europe

Research examines reasons behind variation in prescription practices of antidepressants across Europe

Public attitudes towards mental illness and levels of healthcare spending may explain the huge variation in antidepressant use across Europe, according to a new study by researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London. [More]
St John's Wort may cause same adverse reactions as antidepressants

St John's Wort may cause same adverse reactions as antidepressants

St John's Wort can produce the same adverse reactions as antidepressants, and serious side effects can occur when the two are taken together, according to new University of Adelaide research. [More]
Men referred for borderline testosterone levels have much higher rates of depression than general population

Men referred for borderline testosterone levels have much higher rates of depression than general population

Researchers at the George Washington University, led by Michael S. Irwig, M.D., found that men referred for tertiary care for borderline testosterone levels had much higher rates of depression and depressive symptoms than those of the general population. [More]
Concert Pharmaceuticals’ precision deuteration platform can enhance metabolic properties of drugs

Concert Pharmaceuticals’ precision deuteration platform can enhance metabolic properties of drugs

Substituting deuterium for certain hydrogen atoms in molecules has been shown to enhance the metabolic properties of a number of drugs and provides a promising approach to the discovery and development of innovative drug products. [More]
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