Apolipoprotein News and Research

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Breakthrough genome-wide study uncovers new loci impacting apolipoprotein E levels and Alzheimer's risk

New genetic factors that affect the plasma apolipoprotein E levels.

8 Sep 2023

New biomarker could help identify people at risk for vascular dementia

Dementia is a group of brain diseases that share similar symptoms, such as memory, language, orientation, and behavioral issues. Vascular dementia generally develops in the elderly, affecting between 1% and 4% of people over the age of 65, according to Alzheimer's Switzerland.

4 Sep 2023

Scientists discover new role for liver tPA in regulating cholesterol levels

Despite advances in treatment for high cholesterol, heart disease remains the leading cause of death in the U.S. Scientists at the Medical College of Wisconsin (MCW) are investigating the role of a form of cholesterol called very-low-density lipoprotein – and their findings may lead to new treatment options in the future.

1 Sep 2023

Higher educational attainment may have a protective effect against Alzheimer's in people with genetic risk

A new study by researchers from Mass General Brigham further illustrates that when it comes to risk of Alzheimer's disease, even genetically determined forms of the disease, genetics is only one piece of the puzzle.

30 Aug 2023

Can muvalaplin achieve safe and tolerable plasma concentrations adequate to reduce steady-state Lp(a) levels without modulating plasminogen activity in humans?

Researchers evaluated the tolerability, safety, pharmacodynamics, and pharmacokinetic properties of muvalaplin.

30 Aug 2023

Inflammatory diets raise dementia and Alzheimer's risk

This research study links higher Dietary Inflammatory Index (DII) scores to an increased risk of developing dementia, specifically Alzheimer's disease. The findings suggest that anti-inflammatory diets may offer a preventive strategy for dementia, underlining the need for further research to validate these associations.

28 Aug 2023

How diet and exercise may rewrite the Alzheimer's script at a molecular level

Researchers explore how lifestyle changes like diet and physical activity can influence microRNA expression in Alzheimer's patients, potentially offering new therapeutic avenues. The study fills a research gap in understanding how such lifestyle modifications could affect molecular mechanisms implicated in Alzheimer’s disease.

28 Aug 2023

The cognitive effects of the MIND diet

The effects of a three-year dietary intervention on cognitive decline in older adults.

21 Aug 2023

Is there an association between sleep-disordered breathing and Alzheimer's disease?

Researchers evaluated the impact of sleep-disordered breathing (SDB) on neuroimaging biomarkers of Alzheimer's disease (AD).

21 Aug 2023

New study offers preliminary estimates of mortality risk by stage in Alzheimer's disease

Researchers examine the expected survival of people at each stage of Alzheimer's disease.

17 Aug 2023

Significant association found between the rs1205 T-Dom genotype and risk of COVID-19 death or hospitalization among American Indians

Researchers identify an association between the C-reactive protein gene variant rs1205 and COVID-19 severity.

14 Aug 2023

Study reveals APOE-ε4 allele increases the risk for Alzheimer's and cardiovascular disease

Previous research has revealed that the Apolipoprotein-ε4 (APOE-ε4) allele increases the risk for a variety of diseases in aging populations, specifically Alzheimer's and cardiovascular disease. And yet, despite the negative effects of this genetic variant, it remains prevalent in approximately 20% of the human population.

11 Aug 2023

Study provides clues to how harmful T cells cause heart disease

Scientists can finally hunt down a harmful kind of human T cell, thanks to new research led by scientists at La Jolla Institute for Immunology (LJI) and the Medical College of Georgia (MCG) at Augusta University.

10 Aug 2023

Gene linked to Alzheimer's may also have fertility benefits

Previous research has revealed that the Apolipoprotein-ε4 (APOE-ε4) allele increases the risk for a variety of diseases in aging populations, specifically Alzheimer's and cardiovascular disease.

9 Aug 2023

Study finds genetic overlap between IBS, gastrointestinal diseases, and psychiatric disorders

Researchers characterized the genetic architecture of IBS and investigated genetic overlap with gastrointestinal and psychiatric phenotypes.

8 Aug 2023

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Study aimed to understand the specific needs of lung cancer in never smokers (LCINS) patients.

25 Jul 2023

Researchers develop novel system to identify new therapeutics for familial hypercholesterolemia

The Mona Lisa, painted by the Italian artist Leonardo da Vinci, is one of the most recognizable paintings in the world. But many people would be surprised to learn that this painting offers the first evidence of a disease called familial hypercholesterolemia (FH).

20 Jul 2023

The brain structure of superagers: identifying demographic, lifestyle, and clinical factors associated with their phenotype

Researchers used machine learning models to assess the physical and primarily mental performance of superagers.

19 Jul 2023

A machine-learning approach for monitoring the progression of Alzheimer's disease

Researchers evaluate the predictive value of a multidimensional machine learning approach for monitoring the progression of Alzheimer’s disease.