Autophagy News and Research RSS Feed - Autophagy News and Research

Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.
Four UC San Diego researchers selected to receive newly established NCI Outstanding Investigator Award

Four UC San Diego researchers selected to receive newly established NCI Outstanding Investigator Award

Four University of California, San Diego School of Medicine researchers have been selected to receive the newly established National Cancer Institute (NCI) Outstanding Investigator Award. The multi-million dollar awards fund new projects that have an unusual potential in cancer research over seven years. [More]
Two proteins that help cells eliminate trash may contribute to development of Parkinson's disease

Two proteins that help cells eliminate trash may contribute to development of Parkinson's disease

Two proteins that share the ability to help cells deal with their trash appear to need each other to do their jobs and when they don't connect, it appears to contribute to development of Parkinson's disease, scientists report. [More]
New approach holds great promise for developing effective treatments for human mitochondrial diseases

New approach holds great promise for developing effective treatments for human mitochondrial diseases

Using existing drugs, such as lithium, to restore basic biological processes in human cells and animal models, researchers may have broken a long-standing logjam in devising effective treatments for human mitochondrial diseases. [More]
What do cells really look like in 3D?

What do cells really look like in 3D?

Nanolive SA, a start-up company founded in November 2013 at the EPFL Innovation Park in Lausanne, Switzerland, has developed a revolutionary microscope which allows for the very first time the exploration of a living cell in 3D without damaging it. [More]
Scientists develop small molecule drug that prevents autophagy from starting in cancer cells

Scientists develop small molecule drug that prevents autophagy from starting in cancer cells

As a tumor grows, its cancerous cells ramp up an energy-harvesting process to support its hasty development. This process, called autophagy, is normally used by a cell to recycle damaged organelles and proteins, but is also co-opted by cancer cells to meet their increased energy and metabolic demands. [More]
VG Life Sciences receives U.S. patent for combination cancer therapy

VG Life Sciences receives U.S. patent for combination cancer therapy

VG Life Sciences, Inc., a biotechnology company developing therapies for cancer, autoimmune and infectious diseases, announced that the U.S. Patent and Trademark Office will issue Patent No. 9073985 covering VGLS' combination therapy for treating drug-resistant cancer by combining an autophagy inhibitor with a chemotherapy drug. [More]
Frankfurt researchers decode molecular details that provide better understanding of neurodegenerative diseases

Frankfurt researchers decode molecular details that provide better understanding of neurodegenerative diseases

Quality control is important - this is not only applicable to industrial production but also true for all life processes. However, whereas an enterprise can start a large-scale recall in case of any doubt, defects in the quality control systems of cells are often fatal. [More]

Study shows autophagic defects are linked to sarcopenia

Sarcopenia is the aging-related loss of skeletal muscle mass and strength. Preventing sarcopenia is important for maintaining a high quality of life (QOL) in the aged population. [More]
New finding may lead to development of immunity-based therapies for tuberculosis

New finding may lead to development of immunity-based therapies for tuberculosis

A study by researchers at UT Southwestern Medical Center has identified how an enzyme involved in protecting the body from pathogens senses Mycobacterium tuberculosis (TB), a bacterial pathogen that infects millions of people worldwide and causes about 1.5 million deaths annually. [More]
Duke researchers reveal how bladder cells can eject UTI-causing bacteria

Duke researchers reveal how bladder cells can eject UTI-causing bacteria

Duke Medicine researchers have found that bladder cells have a highly effective way to combat E. coli bacteria that cause urinary tract infections (UTIs). [More]
Major breakthrough in understanding development of type 1 diabetes

Major breakthrough in understanding development of type 1 diabetes

Joslin researchers have uncovered the action of a gene that regulates the education of T cells, providing insight into how and why the immune system begins mistaking the body's own tissues for targets. The gene, Clec16a, is one of a suite of genes associated with multiple autoimmune disorders, suggesting it is fundamental to the development of autoimmunity. [More]
Researchers discover key mechanism in neural death that causes Parkinson's disease

Researchers discover key mechanism in neural death that causes Parkinson's disease

In studying the molecular biology of brain development, a team of researchers led by Ludwig Stockholm director Thomas Perlmann has discovered how disruption of a developmental mechanism alters the very nerve cells that are most affected in Parkinson's disease. [More]
Autophagy: A new approach to fighting tuberculosis

Autophagy: A new approach to fighting tuberculosis

A new approach to combatting tuberculosis would take advantage of a complex, natural process called autophagy that the human body uses to recycle nutrients, remove damaged cell components, eliminate invading bacteria, and respond to inflammation. [More]
Plymouth researchers receive grant to develop effective therapy for Huntington's disease

Plymouth researchers receive grant to develop effective therapy for Huntington's disease

Huntington's disease is an hereditary disorder of the nervous system caused by a faulty gene on chromosome four. The faulty gene leads to nerve damage in the area of the brain resulting in gradual physical, mental and emotional changes. Those born to a parent with Huntington's disease have a 50:50 chance of developing it, and there is currently no cure. [More]
Discovery can help stop emergence of age-related neurodegenerative diseases

Discovery can help stop emergence of age-related neurodegenerative diseases

As medicine has improved, increasing our ability to treat disease, so our longevity. The deterioration of the body with age, though, is a whole other matter. [More]
Researchers reveal how bacterial molecule controls the body's response to TB infection

Researchers reveal how bacterial molecule controls the body's response to TB infection

The cascade of events leading to bacterial infection and the immune response is mostly understood. However, the molecular mechanisms underlying the immune response to the bacteria that causes tuberculosis have remained a mystery — until now. Researchers at the Johns Hopkins University School of Medicine have now uncovered how a bacterial molecule controls the body's response to TB infection and suggest that adjusting the level of this of this molecule may be a new way to treat the disease. [More]
Scientists discover DNA vaccine that alleviates chronic inflammation in the body

Scientists discover DNA vaccine that alleviates chronic inflammation in the body

An international team of scientists including CureLab Oncology, Inc. (Boston), University of Camerino (Italy), and Boston University have serendipitously discovered a DNA vaccine, which systemically alleviates chronic inflammation in the body. Since osteoporosis is an inflammatory disease, preventive and therapeutic effects of the new vaccine were demonstrated on mouse models with osteoporosis. [More]
High-fat diet may reduce heart attack damage by 50%

High-fat diet may reduce heart attack damage by 50%

It's well known that over the long run, a high-fat diet increases the risk of heart attack and stroke. [More]
Short-term, high-fat diet may reduce heart attack damage, shows study

Short-term, high-fat diet may reduce heart attack damage, shows study

It's well known that over the long run, a high-fat diet increases the risk of heart attack and stroke. [More]
TSRI scientists discover novel mechanism involved in Alzheimer's, Parkinson's and ALS

TSRI scientists discover novel mechanism involved in Alzheimer's, Parkinson's and ALS

Scientists from the Florida campus of The Scripps Research Institute have for the first time discovered a killing mechanism that could underpin a range of the most intractable neurodegenerative diseases such as Alzheimer's, Parkinson's and ALS. [More]
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