B Lymphocyte News and Research

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Lexicon files investigational NDA for LX2931 in rheumatoid arthritis

Lexicon Pharmaceuticals, Inc. has announced that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration (FDA) for LX2931, an oral drug candidate for rheumatoid arthritis and other autoimmune conditions.

13 Nov 2007

High-fat diet makes mice susceptible to liver injury

A high fat diet may kill regulatory T cells in the liver, allowing steatosis (simple fatty liver) to develop into steatohepatitis (fatty liver with inflammation), according to the results of a new study in the November issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD).

2 Nov 2007

Ubiquitin builds up an immune response

Ubiquitin is a small protein, which can be attached to other cellular proteins, a process known as ubiquitination.

22 Oct 2007

Low prevalence of Helicobacter pylori in HIV-positive patients

Helicobacter pylori has been extensively studied and proven to be the main cause of chronic gastritis and peptic ulcer in the HIV-negative population.

17 Oct 2007

Breast cancer radiation does not affect women's immune system

A new study shows that neither of two commonly used radiation treatments for early-stage, node-negative breast cancer has any effect on a woman's immune system, even though women who receive five-day partial-breast radiation therapy (MammoSite brachytherapy) (PBRT) have improved energy and quality of life compared to women who undergo six weeks of whole-breast radiation therapy (WBRT).

15 Oct 2007

Ostructive sleep apnea and continuous positive airway pressure

Researchers in Brazil have found that treating patients who suffer from obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) dramatically reduces early indications of atherosclerosis in just months, linking OSA directly to the hardening or narrowing of the arteries.

29 Sep 2007

Researchers uncover likely source of rejection for otherwise well-matched kidney transplants

UT Southwestern Medical Center researchers, collaborating with colleagues in Germany, have for the first time identified antibodies associated with transplant rejection of otherwise healthy kidneys.

27 Sep 2007

Pregnancy may slow AIDS progression

A new study may help put to rest fears that pregnancy accelerates progression to full-blown AIDS in women with HIV receiving antiretroviral therapy.

20 Sep 2007

HIV patients with declining platelet counts appear to be at increased risk for HIV-associated dementia

Therapies leading to longer life for HIV patients have paradoxically increased the prevalence of this condition. Identifying biological markers for the development of HIV–associated dementia is critical both for diagnosing the disorder and for understanding its underlying mechanisms.

11 Sep 2007

Study identifies osteopontin as a key player in the body's immune response to chronic stress

Osteopontin (OPN), a protein molecule involved in many different cellular processes, plays a significant role in immune deficiency and organ atrophy following chronic physiological stress, resulting in increased susceptibility to illness.

4 Sep 2007

Genetics of imatinib resistance in acute lymphoblastic leukemia

In the September 15th issue of Genes & Development, Drs. Richard T. Williams, Willem den Besten, and Charles J. Sherr at Howard Hughes Medical Institute, St. Jude Children's Research Hospital in Memphis TN, lend new insights into how an aggressive form of acute lymphoblastic leukemia (ALL) develops, and how sensitivity to the targeted chemotherapeutic drug, imatinib, can be diminished through interactions between tumor cells and the host microenvironment.

30 Aug 2007

Researchers discover what makes lymphomas tick

University of Pennsylvania researchers and their colleagues at the Wistar Institute and University of Oxford have discovered the molecular process by which the PAX5 protein, necessary for lymphocyte development, promotes the growth of common lymphomas, thereby unveiling a potential new target in the fight against cancer.

30 Aug 2007

RNA essential for survival of mature neurons

There are lots of things that brain cells need to survive. Add to that list microRNAs.

19 Jul 2007

Scientists discover role of ataxia telangiectasia mutated protein in DNA repair

Scientists from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Cancer Institute (NCI), and Integrative Bioinformatics Inc. have made an important discovery about the role of an enzyme called ataxia telangiectasia mutated protein (ATM) in the body's ability to repair damaged DNA.

28 Jun 2007

How 'memory' T cells protect the body from viral diseases

A scientific discovery by Fox Chase Cancer Center researchers helps explain how 'memory' T cells protect the body from viral diseases.

19 Jun 2007

Simple blood test could predict relapse or survival for children and young adults with acute leukemias

A review of young leukemia patients over the past decade has shown that the absolute lymphocyte count (ALC), a measure of normal immune cells found on every complete blood count report, is a powerful predictor of survival for young patients with leukemia.

8 May 2007