BRCA1 Gene News and Research RSS Feed - BRCA1 Gene News and Research

BRCA1 is a gene on chromosome 17 that normally helps to suppress cell growth. A person who inherits certain mutations (changes) in a BRCA1 gene has a higher risk of getting breast, ovarian, prostate, and other types of cancer.
Women with BRCA1 gene mutation at increased risk of aggressive uterine cancer

Women with BRCA1 gene mutation at increased risk of aggressive uterine cancer

Women who carry the BRCA1 gene mutation that dramatically increases their risk of breast and ovarian cancers are also at higher risk for a lethal form of uterine cancer, according to a study led by a Duke Cancer Institute researcher. [More]
Denosumab drug that inhibits RANKL gene can prevent genetic breast cancer

Denosumab drug that inhibits RANKL gene can prevent genetic breast cancer

An international team led by researchers at the Austrian Institute of Molecular Biotechnology in Vienna and the University of Maryland School of Medicine in Baltimore discovered that genetically determined breast cancer can be largely prevented by blocking a bone gene. An already approved drug could be quickly available and would then be the first breast cancer prevention drug. [More]
Research describes how gene BRCA1 plays vital role in DNA repair

Research describes how gene BRCA1 plays vital role in DNA repair

Scientists at the University of Birmingham are a step closer to understanding the role of the gene BRCA1. Changes in this gene are associated with a high risk of developing breast and ovarian cancer. [More]
Auranofin drug could improve prognosis for ovarian cancer patients exhibiting BRCA1 deficiency

Auranofin drug could improve prognosis for ovarian cancer patients exhibiting BRCA1 deficiency

An anti-rheumatic drug could improve the prognosis for ovarian cancer patients exhibiting a deficiency of the DNA repair protein BRCA1, a study suggests. [More]
Low levels of BRCA1 protein in the brain linked to dementia

Low levels of BRCA1 protein in the brain linked to dementia

Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer's disease. The results, published in Nature Communications, suggest that low levels of BRCA1 protein in the brain may contribute to dementia. [More]
Breastfeeding associated with lower risk of developing hormone-receptor negative breast cancer

Breastfeeding associated with lower risk of developing hormone-receptor negative breast cancer

A large international study shows that breastfeeding is associated with a lower risk of developing an aggressive form of breast cancer called hormone-receptor negative. This new combined evidence shows the risk was reduced by up to 20% in women who breastfed. [More]
Scientists develop new molecular toolkit to investigate protein assemblies in human disease

Scientists develop new molecular toolkit to investigate protein assemblies in human disease

A photograph may reveal how something looks, but direct observation can divulge how the objects behave. The difference can mean life or death, especially when it comes to fighting human disease. [More]
Research: Cancer preventative surgery may not be necessary in the future

Research: Cancer preventative surgery may not be necessary in the future

Surgery to remove the breasts of women at increased risk of developing breast cancer may not be necessary in the future, according to research published in EBioMedicine. Two new studies looking at the effect the menstrual cycle has on the development of breast and ovarian cancer reveal alternative prevention strategies that may render surgery unnecessary. [More]
Celebrity impact on breast cancer screening

Celebrity impact on breast cancer screening

Angelina Jolie received widespread media attention in 2013 when she told the public that she'd tested positive for BRCA1, a gene associated with an increased risk of breast and ovarian cancers, and subsequently had a double mastectomy. Now research shows that this publicity did influence some women's intentions to seek out similar genetic testing. [More]
New Internet tool may help analyze genes based on their evolutionary profile

New Internet tool may help analyze genes based on their evolutionary profile

Two major revolutions, one genomic and one in informatics, are completely changing the face of biomedical research. Every day all over the world, millions of genetic sequences -- from disease-related genes to complete genomes of plants, animals, bacteria and viruses -- are resolved, identified and dissected. [More]
Study demonstrates potential of new approach for sorting out BRCA1 gene variants

Study demonstrates potential of new approach for sorting out BRCA1 gene variants

Patients seeking certainty in genetic tests often receive a perplexing result. Many learn they carry a 'variant of unknown significance' of a disease-linked gene. Such variants might -- or equally might not -- increase disease risk. [More]
Oxis Biotech executes licensing agreement with MCIT for development of antibody-drug conjugates

Oxis Biotech executes licensing agreement with MCIT for development of antibody-drug conjugates

Oxis Biotech, Inc., a wholly owned subsidiary of Oxis International, Inc., announced today the execution of a definitive licensing and development agreement with MultiCell Immunotherapeutics, Inc. concerning the development of certain antibody-drug conjugates (ADCs). [More]
BRCA1/2 analysis: an interview with Jurgi Camblong, CEO of Sophia Genetics

BRCA1/2 analysis: an interview with Jurgi Camblong, CEO of Sophia Genetics

BRCA1 and BRCA2 genes are two of the most well studied genes in the cancer field. They are tumor suppressors - mutations in these genes can lead to breast and/or ovarian cancer. Predispositions can be detected in women before they develop cancer. [More]
Sophia Genetics obtains CE-IVD marking for BRCA1/2 testing solution

Sophia Genetics obtains CE-IVD marking for BRCA1/2 testing solution

Sophia Genetics, the European leader in Data Driven Medicine, has today obtained CE-IVD marking for its solution to detect BRCA1/2 associated genetic variants in live tumours. [More]
Scientists show how BRCA2 protein works to repair damaged DNA

Scientists show how BRCA2 protein works to repair damaged DNA

Scientists have taken pictures of the BRCA2 protein for the first time, showing how it works to repair damaged DNA. [More]
Genetic testing for breast cancer doubled due to 'Angelina Jolie effect'

Genetic testing for breast cancer doubled due to 'Angelina Jolie effect'

In May 2013 Angelina Jolie, who was then Hollywood's highest-paid actress, underwent a double mastectomy after testing positive for a BRCA1 gene mutation that significantly increases the risk of developing breast cancer. A recent study, published by Breast Cancer Research has found that, public knowledge of her decision doubled NHS referrals for genetic testing for breast cancer risk. [More]
Human genetics expert wins 2014 Basser Global Prize for BRCA-related research

Human genetics expert wins 2014 Basser Global Prize for BRCA-related research

Twenty years after the first identification of the BRCA1 gene, the University of Pennsylvania's Basser Research Center for BRCA will honor the geneticist credited with its founding with the second annual Basser Global Prize. [More]
Researchers investigate hereditary breast cancer to find new treatment approaches

Researchers investigate hereditary breast cancer to find new treatment approaches

Deborah Kelly and Zhi Sheng, assistant professors at the Virginia Tech Carilion Research Institute, recently received a grant from the Commonwealth Health Research Board to investigate hereditary breast cancer, an effort that may lead to new treatment approaches. [More]
Tubal ligation and breastfeeding may lower risk of ovarian cancer in women with BRCA gene mutations

Tubal ligation and breastfeeding may lower risk of ovarian cancer in women with BRCA gene mutations

Breastfeeding, tubal ligation - also known as having one's "tubes tied" - and oral contraceptives may lower the risk of ovarian cancer for some women with BRCA gene mutations, according to a comprehensive analysis from a team at the University of Pennsylvania's Basser Research Center for BRCA and the Abramson Cancer Center. [More]
Scientists uncover surprising link between brain development and gene tied to breast cancer

Scientists uncover surprising link between brain development and gene tied to breast cancer

Scientists at the Salk Institute have uncovered details into a surprising-and crucial-link between brain development and a gene whose mutation is tied to breast and ovarian cancer. [More]
Advertisement
Advertisement