In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA 1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be effective against advanced pancreatic and prostate cancers.
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Studies have shown nearly 70 percent of patients with breast cancer do not discuss all surgical options with their surgeon before their initial surgery and that such a discussion significantly affects a woman's treatment decision.
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Hollywood actress Angelina Jolie, who has one of the genes linked to breast cancer, revealed that she underwent a double mastectomy earlier this year to prevent following in the footsteps of her mother and succumbing to breast cancer.
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Patients with prostate cancer and hereditary mutations in the BRCA2 gene have a worse prognosis and lower survival rates than do the rest of the patients with the disease.
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Researchers at Moffitt Cancer Center and colleagues in Toronto and at Yale University studied the long-term survival of women with a BRCA1 or BRCA2 gene mutation who were diagnosed with invasive ovarian cancer. They found that the short-term benefit to having either mutation does not lead to a long-term survival benefit.
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Their battle with cancer is not the only thing that unites the Labrada sisters of Houston who are now cancer-free and strong advocates for women taking charge of their bodies.
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A study published in the October issue of the American Journal of Nursing (AJN) found that young women who learn they have BRCA1 and BRCA2 gene mutations felt differently about options for relationships, treatment, childbearing and careers.
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Preimplantation genetic diagnosis (PGD) for the breast cancer genes BRCA1/2 is now feasible and established, with good success rates for those treated, according to investigators from the reproduction, oncology and genetics centres of the university hospitals of Maastricht and Brussels.
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A team of scientists led by Johns Hopkins researchers have found that more than four in 10 people considered at high risk for hereditary pancreatic cancer have small pancreatic lesions long before they have any symptoms of the deadly disease.
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A new study shows that annual mammogram screenings, combined with ultrasounds and MRIs, significantly increase the detection of cancer in women who had an elevated risk of breast cancer.
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A new study showed that women who have been successfully treated for cancer in one breast and who carry the BRCA1 or BRCA2 cancer gene are at increased risk for developing cancer in their other breast.
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The risk of breast cancer is increased by genetic and lifestyle factors such as the inherited BRCA2 gene, age of having first child, or use of hormone replacement therapy (HRT).
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According to a new major study just two glasses of a wine a day can increase the risk of breast cancer among women by 50%. Researchers also warn that women who drink regularly in their 20s and 30s are far more likely to develop breast cancer in later life, regardless of whether they reduce their alcohol consumption.
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According to study results released this Monday, women with a close relative with breast cancer may not be at a higher risk of getting breast cancer. The findings may bring comfort to women from high-risk families after a 2007 study suggested that simply having a relative with a BRCA1 or BRCA2 mutation raised their risk of developing breast cancer, even if they had tested negative for the genes.
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A population-based analysis of more than 3,000 families including women with breast cancer has found that close relatives of women who carry mutations in a BRCA gene - but who themselves do not have such genetic mutations - do not have an increased risk of developing breast cancer compared to relatives of women with breast cancer who do not have such mutations.
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Too many average-risk women and too few high-risk women receive genetic counseling and testing for hereditary breast and ovarian cancers, research shows. Experts at The University of Texas MD Anderson Cancer Center share advice to help patients and their doctors better evaluate family history and make more sound decisions about who should be tested.
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Scientists at deCODE Genetics and academic collaborators from Iceland, The Netherlands, Spain and Finland today report the discovery of variants in the human genome that associate with increased risk of invasive ovarian cancer, one of the deadliest forms of cancer in women.
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Experts from Cancer Treatment Centers of America (CTCA) provide some clues as to who should be using these tests. They explain that women who have been diagnosed with cancer and/or people who have a strong family history of cancer can consider genetic testing. Red flags to consider are anyone in the family who developed cancer at a young age, multiple family members who developed cancer, if a person experienced bilateral cancer (cancer in both breasts), breast and ovarian cancer in the same woman, or cancer appeared where it wasn’t expected (like breast cancer in men)
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The American Cancer society's pages on breast cancer in men lay out the facts. About 2,000 men are diagnosed with breast cancer each year, which makes it rare: about 100 times more women get the disease. It is known that men, like women, are more likely to develop cancer if they have certain mutations of the BRCA1 and BRCA2 genes. Family history and age contribute to a man's likelihood of developing the disease as well.
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A new study finds that around one woman in 70 is at risk of developing ovarian cancer, which claims more than 4,200 lives a year and this could be attributed to a faulty RAD15D gene. The gene raised the risk to one in 11.
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