Bases News and Research

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Molecular basis for alkaline taste discovered

The sense of taste is among the first to come into contact with food before we ingest it, but whether animals can taste basic or alkaline food and how they do it remained unclear until now.

20 Mar 2023

Common dry cleaning chemical may be an invisible cause of Parkinson's

A common and widely used chemical may be fueling the rise of the world's fastest-growing brain condition – Parkinson's disease.

14 Mar 2023

Simple blood tests for telomeric protein could provide a valuable screen for certain cancers

Once thought incapable of encoding proteins due to their simple monotonous repetitions of DNA, tiny telomeres at the tips of our chromosomes seem to hold a potent biological function that's potentially relevant to our understanding of cancer and aging.

21 Feb 2023

Machine learning algorithm predicts DNA insertion efficiency of prime editing

A new tool to predict the chances of successfully inserting a gene-edited sequence of DNA into the genome of a cell, using a technique known as prime editing, has been developed by researchers at the Wellcome Sanger Institute.

15 Feb 2023

Rockefeller scientists describe the genetics of severe SARS-CoV-2 infection in children

One of the most terrifying aspects of the COVID pandemic has been its unpredictably severe impact on some children.

10 Feb 2023

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Researchers developed a WGS method that read four canonical DNA bases, viz., adenine (A), cytosine (C), guanine (G), and thymine (T) plus 5mC and 5hmC, epigenetic variants of unmodified C to yield an accurate six-letter digital readout in a single workflow.

9 Feb 2023

Win 1 of 15 EVOLVE manual pipette starter packs from INTEGRA Biosciences

Are you looking to accelerate your liquid handling protocols? To combat the issue of tedious volume adjustments, look no further than EVOLVE manual pipettes!

From INTEGRA Biosciences 28 Jan 2023

DNA sequencing method detects where and how small molecule drugs interact with the targeted genome

Many life-saving drugs directly interact with DNA to treat diseases such as cancer, but scientists have struggled to detect how and why they work – until now.

23 Jan 2023

New tool can accurately discover, quantify RNA molecules from error-prone long-read RNA sequencing data

On the journey from gene to protein, a nascent RNA molecule can be cut and joined, or spliced, in different ways before being translated into a protein.

20 Jan 2023

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

Researchers investigated the ability of kinetin (N6-furfurylaminopurine, MB-905) to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proliferation in vitro.

17 Jan 2023

First-ever method for analyzing RNA sequencing data genome-wide using a 'pantranscriptome'

Analyzing a person's gene expression requires mapping their RNA landscape to a standard reference to gain insight into the degree to which genes are "turned on" and perform functions in the body.

16 Jan 2023

“Zone of uncertainty” communicates with the neocortex to rapidly control memory formation

The neocortex is the largest and most complex part of the brain and has long been considered the ultimate storage site for long-term memories. But how are traces of past events and experiences laid down there?

13 Jan 2023

Researchers discover new structures on the surface of living B cells for the first time

Using new microscopic methods in combination with machine learning-based image analysis, researchers from Freiburg have discovered new structures on the surface of living B cells that affect the distribution and possibly the function of their antigen receptors.

11 Jan 2023

The main source of editing of the mpox virus genome during the 2022 outbreak

Researchers investigated the main source of editing of the 2022 mpox virus genome.

11 Jan 2023

Immune system B-cells may be better in predicting HER2-positive breast cancer treatment response

Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have found that measuring activation of immune-system B cells may be better than measuring either T-cell activation or the total number of immune cells in and around a tumor, called tumor-infiltrating lymphocytes (TILs), in predicting whether HER2-positive breast cancer responds to treatment.

5 Jan 2023

Bases News and Research

Molecular basis for alkaline taste discovered

Common dry cleaning chemical may be an invisible cause of Parkinson's

Simple blood tests for telomeric protein could provide a valuable screen for certain cancers

Machine learning algorithm predicts DNA insertion efficiency of prime editing

Rockefeller scientists describe the genetics of severe SARS-CoV-2 infection in children

A single base-resolution sequencing methodology that sequences the two most common cytosine modifications in a single workflow

Win 1 of 15 EVOLVE manual pipette starter packs from INTEGRA Biosciences

DNA sequencing method detects where and how small molecule drugs interact with the targeted genome

New tool can accurately discover, quantify RNA molecules from error-prone long-read RNA sequencing data

Preclinical study shows the therapeutic value of kinetin against SARS-CoV-2

First-ever method for analyzing RNA sequencing data genome-wide using a 'pantranscriptome'

“Zone of uncertainty” communicates with the neocortex to rapidly control memory formation

Researchers discover new structures on the surface of living B cells for the first time

The main source of editing of the mpox virus genome during the 2022 outbreak

Immune system B-cells may be better in predicting HER2-positive breast cancer treatment response

Deep learning tool identifies mosaic mutations that cause disease

Researchers design 3D structures made of DNA

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

Researchers use loop-seq technology to decipher the mechanical code of DNA

Evaluating dual direct-acting antivirals against persistent COVID-19

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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