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Specific mutations in the monkeypox virus contribute to its continued infectiousness

Monkeypox has infected more than 77,000 people in more than 100 countries worldwide, and -; similar to COVID-19 -; mutations have enabled the virus to grow stronger and smarter, evading antiviral drugs and vaccines in its mission to infect more people.

4 Nov 2022

Study reports on a novel property of antibodies, light chain coherence

Researchers investigate whether pairs of unrelated B-cells that have similar heavy chains also have the same light chains.

30 Oct 2022

RNA-sensing platform could help detect and selectively kill tumors, or edit the genome in specific cells

Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have developed a system that can detect a particular RNA sequence in live cells and produce a protein of interest in response.

27 Oct 2022

Hospitals said they lost money on Medicare patients. Some made millions, a state report finds.

Atrium Health, the largest hospital system in North Carolina, has declared publicly that in 2019 it provided $640 million in services to Medicare patients that were never paid for, by far the largest "community benefit" it provided that year.

25 Oct 2022

Variations in low-complexity regions in monkeypox genome found to impact virus transmissibility

In a new study, researchers investigated whether low-complexity regions (LCRs) were more accountable for the current 2022 IIb clade monkeypox (MPX) virus (MPXV) outbreak rather than single-nucleotide polymorphisms (SNPs).

24 Oct 2022

Rapid and robust pipeline for developing mRNA vaccines for future SARS-CoV-2 variants

A recent study under review at the journal Scientific Reports and currently available on the Research Square* preprint server reported the development of a robust pipeline for fabricating an mRNA vaccine portfolio to combat current and future coronavirus outbreaks, other infectious diseases, and cancer.

19 Oct 2022

Novel method deploys nanopore tweezers to facilitate inhibition of SARS-CoV-2 helicase at single-nucleotide resolution

In a new study, researchers visualized the mechanism of action and inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 13 (NSP13) at high spatio-temporal resolution.

13 Oct 2022

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

A new paper reviews current knowledge of RdRp inhibitors that could be developed further to provide broadly effective antivirals against SARS-CoV-2 in particular and CoVs in general.

10 Oct 2022

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

In a new study, researchers explored the crystalline structure of the monkeypox (MPX) virus (MPXV) and the complex of VP39, a 2′-O-RNA methyltransferase (MTase) and sinefungin, a pan-MTase inhibitor.

30 Sep 2022

Study investigates long-range RNA-RNA interactions of SARS-CoV-2

Researchers explored RRIs [long-range ribonucleic acid (RNA)-RNA interactions] in SARS-CoV-2 variants of concern genomes to assess evolutionary changes in SARS-CoV-2.

26 Sep 2022

Virology of the human monkeypox virus

A new review to be posted in the Virus Research journal aims to provide an overview of the recent advances reported concerning hMPXV virology.

21 Sep 2022

Recommendations for the treatment, prevention of monkeypox in nursing mothers

Although none of the preventative or therapeutic agents used in monkeypox have been fully studied in nursing mothers, Philip Anderson, PharmD, from the University of California, San Diego, presents a broad practical recommendation for the treatment and prevention of monkeypox in nursing mothers in an article published in the peer-reviewed journal Breastfeeding Medicine.

20 Sep 2022

First report of a SARS-CoV-2 variant with an ORF7a deletion that dominated an outbreak

In a recent study posted to the medRxiv* preprint server, researchers in Australia determined whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta-ORF7aΔ17del [open reading frame 7a protein with 17-nucleotide (nt) frameshift-inducing deletion] variant has a fitness advantage over the Delta variant lacking the ORF7aΔ17del deletion (Delta-ORF7aintact) and/or the SARS-CoV-2 lineage (A.2.2).

12 Sep 2022

Label-free trace detection of bio-molecules by LI-SERS method

A new publication from Opto-Electronic Advances; DOI 10.29026/oea.2022.210121 discusses label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip.

9 Sep 2022

Bringing flexibility to Sanger sequencing and DNA-fragment analysis with the Spectrum Compact CE System

In this interview, News Med is talking to Gabriela Saldanha about DNA Fragmentation and Sanger Sequencing.

From Promega Corporation 5 Sep 2022

New diagnoses of neurological and psychiatric disorders remain common two years after COVID-19

New diagnoses of disorders including psychosis, dementia, seizures and ‘brain fog’ remain commoner two years after COVID-19 than after other respiratory infections, whereas the increased risks of depression and anxiety after COVID-19 are short-lived and there is no overall excess of cases.

25 Aug 2022

Bases News and Research

Specific mutations in the monkeypox virus contribute to its continued infectiousness

Study reports on a novel property of antibodies, light chain coherence

RNA-sensing platform could help detect and selectively kill tumors, or edit the genome in specific cells

Hospitals said they lost money on Medicare patients. Some made millions, a state report finds.

Variations in low-complexity regions in monkeypox genome found to impact virus transmissibility

Rapid and robust pipeline for developing mRNA vaccines for future SARS-CoV-2 variants

Novel method deploys nanopore tweezers to facilitate inhibition of SARS-CoV-2 helicase at single-nucleotide resolution

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

Study investigates long-range RNA-RNA interactions of SARS-CoV-2

Virology of the human monkeypox virus

Recommendations for the treatment, prevention of monkeypox in nursing mothers

First report of a SARS-CoV-2 variant with an ORF7a deletion that dominated an outbreak

Label-free trace detection of bio-molecules by LI-SERS method

Bringing flexibility to Sanger sequencing and DNA-fragment analysis with the Spectrum Compact CE System

New diagnoses of neurological and psychiatric disorders remain common two years after COVID-19

Reservoir ensures sustainable use of reagents

Costly Chemicals; The Health and Economic Impact of 'Forever Chemicals'

Health inequalities amongst ethnic minorities with diabetes have worsened during the pandemic, study shows

EPA action boosts grassroots momentum to reduce toxic ‘forever chemicals’

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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