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Increasing specific microRNA levels can restore chemotherapy sensitivity in pancreatic cancer cells

Increasing specific microRNA levels can restore chemotherapy sensitivity in pancreatic cancer cells

By increasing the level of a specific microRNA (miRNA) molecule, researchers have for the first time restored chemotherapy sensitivity in vitro to a line of human pancreatic cancer cells that had developed resistance to a common treatment drug. [More]
NR supplements can reduce diabetes-related complications in mice

NR supplements can reduce diabetes-related complications in mice

A naturally occurring vitamin, nicotinamide riboside (NR), can lower blood sugar levels, reduce fatty liver, and prevent peripheral nerve damage in mouse models of prediabetes and type 2 diabetes (T2D), according to a new study by researchers at the University of Iowa and the Iowa City VA Health Care System. [More]
Metabolic characteristics of CRPC may open new avenues for treatment

Metabolic characteristics of CRPC may open new avenues for treatment

Advanced prostate cancer is usually treated by removing androgen, the male hormone that helps it grow. Although initially effective, this treatment often leads to the tumor becoming castration resistant- a lethal condition. [More]
UT Southwestern study offers more insight into cholesterol transporter

UT Southwestern study offers more insight into cholesterol transporter

Using X-ray crystallography, UT Southwestern Medical Center researchers have determined the 3-D atomic structure of a human sterol transporter that helps maintain cholesterol balance. [More]
RBFOX2 dysregulation may cause heart damage in diabetic patients

RBFOX2 dysregulation may cause heart damage in diabetic patients

Cardiac complications are the number one cause of death among diabetics. Now a team of scientists has uncovered a molecular mechanism involved in a common form of heart damage found in people with diabetes. [More]
Could a new test improve bowel cancer screening uptake? An interview with Professor Halloran

Could a new test improve bowel cancer screening uptake? An interview with Professor Halloran

The most recent complete data for England (2014/15) shows an average uptake of the guaiac Faecal Occult Blood Tests (gFOBT) from those invited by the NHS Bowel Cancer Screening Programme (BCSP) of 58.22%. [More]
Researchers identify trigger for immune cells' inflammatory response

Researchers identify trigger for immune cells' inflammatory response

Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response - a discovery that may pave the way for new treatments for many human diseases. [More]
New spectral triangulation system may help pinpoint targeted cancer tumors

New spectral triangulation system may help pinpoint targeted cancer tumors

Bathing a patient in LED light may someday offer a new way to locate tumors, according to Rice University researchers. [More]
Two-way communication between cancer cells may be key to tumor metastasis

Two-way communication between cancer cells may be key to tumor metastasis

Two-way communication between cancer cells appears to be key to their becoming motile, clustering and spreading through metastasis, according to Rice University scientists. [More]
Study examines effects of ultra-low doses of glyphosate on gene expression profiles

Study examines effects of ultra-low doses of glyphosate on gene expression profiles

Glyphosate, often sold under the brand name of Roundup, is the world's most widely used weed-killer. While Glyphosate has approval from regulatory bodies worldwide, there are growing concerns about its possible adverse health effects. [More]
New drug that combines methicillin with polymer BPEI can combat MRSA

New drug that combines methicillin with polymer BPEI can combat MRSA

A University of Oklahoma team of chemists has developed a new antibiotic formulation to fight the sometimes deadly staph infection caused by methicillin-resistant S. aureus or MRSA and other antibiotic-resistant infectious bacteria. [More]
Innovative research technique may help understand early stage kidney disease

Innovative research technique may help understand early stage kidney disease

UT Dallas scientists are developing an innovative research technique that could help urologists better understand the early stages of kidney disease. [More]
Mouse model of depression can help better understand how ketamine functions

Mouse model of depression can help better understand how ketamine functions

New research demonstrates the effectiveness of ketamine to treat depression in a mouse model of the disease and brings together two hypotheses for the cause of depression. [More]
Consuming sesame-based ingredients may reduce oxidative stress

Consuming sesame-based ingredients may reduce oxidative stress

The antioxidant boosting properties of sesame, and especially sesame oil, can have a significant effect on oxidative stress, improving human health, according to a systematic review published in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. [More]
McGill researchers discover role of folliculin protein in regulating activity of fat cells

McGill researchers discover role of folliculin protein in regulating activity of fat cells

Researchers have uncovered a new molecular pathway for stimulating the body to burn fat - a discovery that could help fight obesity, diabetes and cardiovascular disease. [More]
Unlocking the dark proteome: an interview with Dr Kriwacki

Unlocking the dark proteome: an interview with Dr Kriwacki

The term dark proteome refers to proteins whose structural features and thus functions are not well understood. Many proteins within the dark proteome do not fold into stable three-dimensional structures. These proteins are called intrinsically disordered proteins (IDPs) and feature highly flexible, disordered confirmations. [More]
Titanium dioxide nanoparticles can have low-level effects on oxidative stress genes

Titanium dioxide nanoparticles can have low-level effects on oxidative stress genes

A nanoparticle commonly used in food, cosmetics, sunscreen and other products can have subtle effects on the activity of genes expressing enzymes that address oxidative stress inside two types of cells. [More]
MUSC Hollings Cancer Center receives $8.9 million grant to explore signaling in sphingolipids

MUSC Hollings Cancer Center receives $8.9 million grant to explore signaling in sphingolipids

The Medical University of South Carolina's Hollings Cancer Center received an $8.9 million grant from the National Cancer Institute designed to foster collaboration across clinical and laboratory research for the study of signaling in sphingolipids, a class of lipids known to be involved in the growth of solid tumor cancers. [More]
Importance of understanding ovarian cancer on molecular level

Importance of understanding ovarian cancer on molecular level

Nearly 70 percent of ovarian cancer cases are detected after metastasis, which is the development of secondary malignant growths distant from the primary site of cancer. [More]
ITJ researchers develop new hydrating beverage for athletes

ITJ researchers develop new hydrating beverage for athletes

Jiquiquilpan's Institute of Technology in Mexico developed a hydrating beverage for athletes that is based on agave's fructans, that not only supplies the adequate water levels to the organisms, but also offers other benefits such as dietetic fiber. [More]
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