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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.
New UM SOM study reveals why thiazide drugs not effective in some patients

New UM SOM study reveals why thiazide drugs not effective in some patients

Every year, more than 120 million prescriptions are written worldwide for thiazide drugs, a group of salt-lowering medicines used to treat high blood pressure. These drugs are often work very well, and over decades have saved hundreds of thousands of lives. [More]
MGH researchers find probable mechanism associated with risk of developing serious diseases

MGH researchers find probable mechanism associated with risk of developing serious diseases

Massachusetts General Hospital investigators have found the probable mechanism underlying a previously described biomarker associated with the risk of developing serious diseases ranging from cancer to cardiovascular disease and the risk of serious complications. In a paper published in the American Journal of Hematology, the research team reports finding that higher levels of a measure routinely taken as part of the complete blood count - the extent of variation in the size of red blood cells - is caused by reduced clearance of aging cells from the bloodstream. [More]
Scientists reveal three major subsets of KRAS-mutant LUAC

Scientists reveal three major subsets of KRAS-mutant LUAC

Mutations of the KRAS gene are commonly known to lead to cancer. However, deeper understanding of exactly how they do this continues to be explored by cancer researchers. [More]
Plaque can be used to predict, identify and treat diseases, say researchers

Plaque can be used to predict, identify and treat diseases, say researchers

Scraped from the gums, teeth and tongue in the form of plaque, the researchers behind Canada's first plaque bank are betting that the bacterial content of plaque will open up a new frontier of medicine. [More]
Leica Biosystems announces launch of Aperio VERSA scanner at AACR annual meeting

Leica Biosystems announces launch of Aperio VERSA scanner at AACR annual meeting

Leica Biosystems announces the introduction of the Aperio VERSA, a combination digital pathology research scanner for brightfield, fluorescence and FISH imaging at the American Association for Cancer Research annual meeting in Philadelphia, opening on April 18th, 2015. [More]
New metabolic blood profile method could help predict breast cancer

New metabolic blood profile method could help predict breast cancer

According to the World Health Organization, breast cancer is the most common cancer in women both in the developed and less developed world, and in the long term the scientists hope that the new method will lead to better prevention and early treatment of the disease. [More]
Researchers discover new biomarker to identify women with uterine cancer

Researchers discover new biomarker to identify women with uterine cancer

Researchers at Uppsala University have, together with researchers from Turku and Bergen, discovered a new biomarker which makes it possible to identify women with uterine cancer who have a high risk of recurrence. [More]
Phase–amplitude coupling changes may underlie DBS success in parkinsonism

Phase–amplitude coupling changes may underlie DBS success in parkinsonism

Deep-brain stimulation of the subthalamic nucleus may improve motor symptoms in patients with Parkinson’s disease by reducing excessive cortical phase–amplitude coupling, researchers report in Nature Neuroscience. [More]
Eyenuk's EyeArt automated high-throughput diabetic retinopathy screening receives CE Mark

Eyenuk's EyeArt automated high-throughput diabetic retinopathy screening receives CE Mark

Eyenuk, Inc. announced today that it received CE Marking for its pioneering EyeArt software, a suite of advanced image analysis tools for automated high-throughput screening of diabetic retinopathy. The company plans to launch its product in select leading eye care sites across Europe in the next few months. [More]
U-M researchers make major breakthrough in diagnosing, treating prostate cancer

U-M researchers make major breakthrough in diagnosing, treating prostate cancer

University of Michigan researchers have discovered a biomarker that may be a potentially important breakthrough in diagnosing and treating prostate cancer. [More]
Bionomics to present BNC105 trial results of metastatic renal cancer at Asian Oncology Summit

Bionomics to present BNC105 trial results of metastatic renal cancer at Asian Oncology Summit

Bionomics Limited (ASX: BNO, OTCQX: BNOEF) today announced that it will present a poster with new data on the DisrupTOR-1 trial of BNC105 in patients with metastatic renal cancer at the 7th Asian Oncology Summit being held from April 10-12, 2015 in Shanghai, China. [More]
fMRI can predict language development outcomes in ASD toddlers

fMRI can predict language development outcomes in ASD toddlers

Using functional magnetic resonance imaging (fMRI), University of California, San Diego School of Medicine researchers say it may be possible to predict future language development outcomes in toddlers with autistic spectrum disorder (ASD), even before they've been formally diagnosed with the condition. [More]
New, cross-sector collaboration aims to discover clinical biomarker for pancreatic cancer

New, cross-sector collaboration aims to discover clinical biomarker for pancreatic cancer

The search to discover and validate the first-ever clinical biomarker to diagnose and treat pancreatic cancer is at the foundation of a new, cross-sector collaboration. Berg, a biopharmaceutical company committed to uncovering health solutions through a data-driven, biological research approach; the Cancer Center at Beth Israel Deaconess Medical Center, a Harvard Medical School teaching hospital, and the Pancreatic Cancer Research Team managed by Cancer Research And Biostatistics announced today they will work together to eradicate the disease. [More]
Neuro-oncology researchers identify mechanism responsible for tumor cell invasion in glioblastoma

Neuro-oncology researchers identify mechanism responsible for tumor cell invasion in glioblastoma

A neuro-oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma. [More]
Bilirubin levels raised in newly diagnosed Parkinson’s disease

Bilirubin levels raised in newly diagnosed Parkinson’s disease

Bilirubin levels are upregulated in patients with early Parkinson’s disease and are associated with disease progression at 2 years, a study shows. [More]
Sanford-Burnham, Daiichi Sankyo sign licensing agreement to expand development of small molecule

Sanford-Burnham, Daiichi Sankyo sign licensing agreement to expand development of small molecule

Sanford-Burnham Medical Research Institute today announced that it has signed a licensing agreement to further develop a first-in-class small molecule with Daiichi Sankyo for the treatment of cardiovascular-metabolic disease. [More]
Study: Placenta can be used to measure arsenic exposure in pregnant women, fetuses

Study: Placenta can be used to measure arsenic exposure in pregnant women, fetuses

The placenta can be used to reliably measure arsenic exposure in pregnant women and how much of the toxic metal is transferred to their fetuses, a Dartmouth College study shows. [More]
Combination of signaling molecules can inhibit growth of breast cancer cells

Combination of signaling molecules can inhibit growth of breast cancer cells

Researchers at UT Southwestern Medical Center have uncovered how the body's inflammatory response can alter how estrogen promotes the growth of breast cancer cells. [More]
CentoMD: World's largest genetic mutation database for rare diseases

CentoMD: World's largest genetic mutation database for rare diseases

CENTOGENE AG announces the launch of the world's largest genetic mutation database for rare diseases, CentoMD. CentoMD is a comprehensive and unique repository of genetic variants, including a huge number of unpublished pathogenic variants gathered from patients worldwide. [More]
Genetic markers may predict tumor samples that respond to treatment

Genetic markers may predict tumor samples that respond to treatment

Patients with chronic myelomonocytic leukemia have limited treatment options, and those that exist are effective only in fewer than half of patients. Now, a new study identifies a panel of genetic markers that predicted which tumor samples would likely respond to treatment. [More]
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