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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.
New biomarker helps better predict survival after surgical removal of colorectal metastases

New biomarker helps better predict survival after surgical removal of colorectal metastases

Liver metastases are formed from cancer cells that have originated in other organs and migrated to the liver via the bloodstream. Colorectal cancer (cancer of the colon/rectum) can be successfully treated by surgical resection of the metastases in combination with chemotherapy. [More]
Sedentary lifestyle may hasten biological aging

Sedentary lifestyle may hasten biological aging

Researchers at University of California San Diego School of Medicine report that elderly women who sit for more than 10 hours a day with low physical activity have cells that are biologically older by eight years compared to women who are less sedentary. [More]
Biomarker could help identify heart failure patients suitable for cardiac recovery therapies

Biomarker could help identify heart failure patients suitable for cardiac recovery therapies

Investigators at the University of Utah have identified distinct differences in the hearts of advanced heart failure patients who have defied the odds and showed signs of recovery from the disease. Published online in the journal Circulation, the new findings could help clinicians identify the best candidates for cardiac recovery therapies. [More]
Biomarker linked to depression during pregnancy and low birth weight in baby

Biomarker linked to depression during pregnancy and low birth weight in baby

Depression is very common during pregnancy, with as many as one in seven women suffering from the illness and more than a half million women impacted by postpartum depression in the U.S. alone. [More]
MUSC scientists design novel antibody-based therapy to fight against cancer

MUSC scientists design novel antibody-based therapy to fight against cancer

Scientists at the Medical University of South Carolina (MUSC) have designed an antibody-based therapy that could target the functions of TGF-beta that cause cancer [More]
Childhood obesity starts in the womb?

Childhood obesity starts in the womb?

There is incontrovertible evidence that some harmful drugs and toxins can affect lifelong health. For example, if women take certain drugs in pregnancy, such as thalidomide, there are well documented effects on lifelong health. These have obvious and dramatic effects on the child... [More]
Roswell Park researchers identify gene signatures that may help predict fatal prostate cancers

Roswell Park researchers identify gene signatures that may help predict fatal prostate cancers

Standard therapy for prostate cancer, the third-leading cause of cancer-related deaths in American men, is based on blocking androgens, the male sex hormones. [More]
Elevated levels of brain protein linked to longer recovery period after concussion

Elevated levels of brain protein linked to longer recovery period after concussion

Elevated levels of the brain protein tau following a sport-related concussion are associated with a longer recovery period and delayed return to play for athletes, according to a study published in the January 6, 2017 issue of Neurology, the medical journal of the American Academy of Neurology. [More]
Uterine microbiome study provides important insights into etiology of endometrial cancer

Uterine microbiome study provides important insights into etiology of endometrial cancer

Endometrial cancer triggers remain elusive, despite continued research. But given the typical inflammatory profile in these cases, microbes in the uterine environment are suspected to play a role in the development of this disease. [More]
Giving polycystic kidney disease the bump

Giving polycystic kidney disease the bump

We launched this campaign at the beginning of October 2016. It's the first time that we've ever had a campaign of this size and scope. It's a European campaign in multiple languages that's coordinated by six of the organizations that represent PKD patients in Europe. [More]
IQWiG investigates benefit of biomarker tests to support decision on adjuvant chemotherapy

IQWiG investigates benefit of biomarker tests to support decision on adjuvant chemotherapy

The German Institute for Quality and Efficiency in Health Care (IQWiG) investigated the benefit of biomarker tests to support the decision for or against adjuvant systemic chemotherapy in certain breast cancer patients, that is, women with primary hormone receptor-positive, HER2-negative breast cancer and up to 3 affected lymph nodes. [More]
Whitehead Institute researchers identify mechanism underlying cancer drug-resistance

Whitehead Institute researchers identify mechanism underlying cancer drug-resistance

The use of proteasome inhibitors to treat cancer has been greatly limited by the ability of cancer cells to develop resistance to these drugs. [More]
Hospitals eliminate bedsore occurrence using early detection technology

Hospitals eliminate bedsore occurrence using early detection technology

Using technology adapted from NASA's Mars lander as part of a large-scale bedsore reduction program, over half of the 13 participating hospitals were able to eliminate the occurrence of new bedsores completely; an additional 3 hospitals achieved reductions ranging from 11% to 90%. [More]
UCLA-led research finds promising results for more personalized head and neck cancer treatment

UCLA-led research finds promising results for more personalized head and neck cancer treatment

Researchers have found that people with advanced head and neck squamous cell carcinoma and the KRAS-variant inherited genetic mutation have significantly improved survival when given a short course of the drug cetuximab in combination with standard chemotherapy and radiation. [More]
Tau biomarker could lead to early identification of Alzheimer's disease pathology

Tau biomarker could lead to early identification of Alzheimer's disease pathology

A discovery of high relevance in medical research will be published in Volume 55, number 4 of December 2016 of the prestigious "Journal of Alzheimer's Disease (JAD)", entitled "Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer's Disease". [More]
Groundbreaking research finds concussion biomarker in auditory system

Groundbreaking research finds concussion biomarker in auditory system

The secret to reliably diagnosing concussions lies in the brain's ability to process sound, according to a new study by researchers from Northwestern University's Auditory Neuroscience Laboratory. [More]
Generative AAE can be radically new way to discover drugs on demand

Generative AAE can be radically new way to discover drugs on demand

Scientists at the Pharmaceutical Artificial Intelligence group of Insilico Medicine, Inc, today announced the publication of a seminal paper demonstrating the application of generative adversarial autoencoders (AAEs) to generating new molecular fingerprints on demand. [More]
Biomarker for oxidative stress plays key role in development of NAFLD, study shows

Biomarker for oxidative stress plays key role in development of NAFLD, study shows

Diet-related diseases like non-alcoholic fatty liver disease (NAFLD) are known to have a major inflammatory component. [More]
Hormone receptor could be potential biomarker for gastric cancer, research shows

Hormone receptor could be potential biomarker for gastric cancer, research shows

Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, the Veterans Affairs Medical Center in Miami, and Shantou University Medical College in China, have shown that the hormone receptor GHRH-R could be a potential biomarker for gastric cancer, enabling earlier diagnoses and better staging. [More]
Presence of tumor DNA in blood linked to poor outcomes in pancreatic cancer patients

Presence of tumor DNA in blood linked to poor outcomes in pancreatic cancer patients

The presence of circulating tumor DNA (ctDNA) isolated from blood samples of patients with pancreatic adenocarcinoma was associated with poor outcomes. [More]
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