Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Research reveals potential target for enfortumab vedotin therapy in urothelial carcinoma

Under the leadership of PD Dr. Niklas Klümper, Assistant Physician at the Department of Urology at the University Hospital Bonn (UKB) and Clinician Scientist of the BMBF-funded ACCENT program and PD Dr. Markus Eckstein, senior physician at the Institute of Pathology at the Uniklinikum Erlangen of the Friedrich-Alexander-University Erlangen-Nürnberg (FAU), an interdisciplinary research team has published new findings that indicate which patients with advanced urothelial carcinoma could benefit in particular from the new targeted therapy with the antibody-drug conjugate enfortumab vedotin.

24 Apr 2024

Study unveils novel bladder cancer diagnostic model based on key mitochondrial genes

A novel diagnostic model using machine learning (ML).

24 Apr 2024

Bursts of beta rhythms control cognition in the brain

The brain processes information on many scales. Individual cells electrochemically transmit signals in circuits but at the large scale required to produce cognition, millions of cells act in concert, driven by rhythmic signals at varying frequencies.

23 Apr 2024

New urine-based test improves identification of high-grade prostate cancer

Researchers at the University of Michigan Rogel Cancer Center have developed a new urine-based test that addresses a major problem in prostate cancer: how to separate the slow-growing form of the disease unlikely to cause harm from more aggressive cancer that needs immediate treatment.

18 Apr 2024

WOO Network trials investigate innovative treatments for liver, head and neck cancers

A new round of clinical trials supported by the Ontario Institute for Cancer Research (OICR) will harness a unique opportunity to test some of the newest treatment strategies for a range of different cancers.

18 Apr 2024

Triple-negative breast cancer patients with high immune cell levels have lower relapse risk after surgery

Women with triple-negative breast cancer, and high levels of immune cells in the tumors, have a lower relapse risk after surgery, even without chemotherapy.

17 Apr 2024

Study reveals accelerated progression of Alzheimer's in people with Down syndrome

Nearly all adults with Down syndrome will develop evidence of Alzheimer's disease by late middle age.

16 Apr 2024

Machine learning models identify immunophenotypes in NSCLC for immunotherapy guidance

A new study examines the development of two machine learning models to classify the immunophenotype of a cancer specimen.

16 Apr 2024

Study reveals human gut plasmid with biomarker potential

A component of the human intestinal flora that has been little studied to date is the focus of a new study.

16 Apr 2024

Pitt researchers uncover mechanisms behind uveal melanoma resistance

New research from the University of Pittsburgh explains why metastatic uveal melanoma is resistant to conventional immunotherapies and how adoptive therapy, which involves growing a patient's T cells outside the body before reinfusing them, can successfully treat this rare and aggressive cancer.

16 Apr 2024

Looking inward via mindfulness training for better mental health

From a young age, people learn the importance of paying attention to the environment around them. Less emphasized is the value of paying attention to their inner environment.

15 Apr 2024

Bio-Rad announces collaboration agreement with oncocyte to commercialize transplant monitoring with droplet digital PCR

Collaboration Aims to Provide Researchers Cutting-Edge Tools to Enable Transformational Monitoring of Key Biomarkers in Solid Tissue Transplants.

From Bio-Rad Laboratories 15 Apr 2024

Wearable devices reveal stress-related changes during sleep

What if changes in a person's stress levels could be detected while they sleep using wearable devices? A new study by University of Vermont researchers published today in PLOS Digital Health is the first to find changes in perceived stress levels reflected in sleep data-;an important step towards identifying biomarkers that may help flag individuals in need of support.

13 Apr 2024

Three early-phase clinical studies show promising initial data for patients with lymphoma, gastric cancers

Three early-phase clinical studies presented by researchers from The University of Texas MD Anderson Cancer Center at the American Association for Cancer Research (AACR) Annual Meeting 2024 show promising initial data for patients with lymphoma, gastric or gastroesophageal junction cancers, and specific molecularly selected tumors.

10 Apr 2024

Blood protein could be a potential biomarker for delayed concussion recovery in children

Researchers have discovered a blood protein that could help detect which children will experience ongoing concussion symptoms more than two weeks after an injury.

9 Apr 2024

ACE inhibitors show no benefit in reducing chemotherapy-induced heart damage

Patients who took an angiotensin-converting enzyme (ACE) inhibitor while undergoing cancer treatment with high-dose anthracycline chemotherapy did not show any difference in troponin T levels, a biomarker associated with heart damage, at one month after their last chemotherapy dose compared with those who did not take an ACE inhibitor, according to a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Biomarker News and Research

Further Reading

Research reveals potential target for enfortumab vedotin therapy in urothelial carcinoma

Study unveils novel bladder cancer diagnostic model based on key mitochondrial genes

Bursts of beta rhythms control cognition in the brain

New urine-based test improves identification of high-grade prostate cancer

WOO Network trials investigate innovative treatments for liver, head and neck cancers

Triple-negative breast cancer patients with high immune cell levels have lower relapse risk after surgery

Study reveals accelerated progression of Alzheimer's in people with Down syndrome

Machine learning models identify immunophenotypes in NSCLC for immunotherapy guidance

Study reveals human gut plasmid with biomarker potential

Pitt researchers uncover mechanisms behind uveal melanoma resistance

Looking inward via mindfulness training for better mental health

Bio-Rad announces collaboration agreement with oncocyte to commercialize transplant monitoring with droplet digital PCR

Wearable devices reveal stress-related changes during sleep

Three early-phase clinical studies show promising initial data for patients with lymphoma, gastric cancers

Blood protein could be a potential biomarker for delayed concussion recovery in children

ACE inhibitors show no benefit in reducing chemotherapy-induced heart damage

Heavy alcohol use linked to increased risk of Type 2 diabetes in middle-aged adults

Simple urine test halves cystoscopy procedures for bladder cancer patients

Blood-based DNA test spares bladder cancer patients from unnecessary treatments

Gene defect associated with argininosuccinic aciduria corrected using CRISPR-Cas9 technique

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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