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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.
Study reveals association between DNA methylation and type 2 diabetes

Study reveals association between DNA methylation and type 2 diabetes

Researchers from the Hospital del Mar Medical Research Institute have found an epigenetic mechanism implicated in the regulation of blood sugar. The study, published in the journal Molecular Human Genetics, reveals that the methylation of the TXNIP gene is associated with diabetes mellitus type 2 and, in particular, average blood glucose levels. [More]
University of Oxford, SomaLogic partner to discover protein biomarkers for clinical diseases and conditions

University of Oxford, SomaLogic partner to discover protein biomarkers for clinical diseases and conditions

The University of Oxford and SomaLogic announced today that they have agreed to undertake a number of collaborative projects that will employ SomaLogic's proprietary SOMAmer reagents and SOMAscan assay technologies to discover and characterize protein biomarkers for a range of clinical diseases and conditions. [More]
New personalized DNA-based digital assay has potential to dramatically impact CML management

New personalized DNA-based digital assay has potential to dramatically impact CML management

The outcomes of chronic myeloid leukemia (CML) have dramatically improved as the result of tyrosine kinase inhibitor (TKI) treatment. Use of a TKI regimen can lower the blood CML biomarker to levels imperceptible by current detection methods. For patients in "molecular remission," however, uncertainties remain regarding whether they will relapse or if treatment should be discontinued. [More]
Scientists identify potential marker for recurring HPV-positive oropharyngeal cancer

Scientists identify potential marker for recurring HPV-positive oropharyngeal cancer

A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at The Johns Hopkins University. [More]
VolitionRx initiates study to assess NuQ blood tests for detection of prostate cancer

VolitionRx initiates study to assess NuQ blood tests for detection of prostate cancer

VolitionRx Limited today announced that it has initiated a study to assess the feasibility of using the Company’s NuQ blood tests to detect prostate cancer. The study is in collaboration with the Surrey Cancer Research Institute of the University of Surrey in the UK. [More]
Study provides window into the brain changes that link mindfulness meditation with health-related benefits

Study provides window into the brain changes that link mindfulness meditation with health-related benefits

Over the past decade, mindfulness meditation has been shown to improve a broad range of health and disease outcomes, such as slowing HIV progression and improving healthy aging. Yet, little is known about the brain changes that produce these beneficial health effects. [More]
Duke scientists reveal how gut inflammation increases colon cancer risk

Duke scientists reveal how gut inflammation increases colon cancer risk

Chronic inflammation in the gut increases the risk of colon cancer by as much as 500 percent, and now Duke University researchers think they know why. [More]
BDNF gene expression signals cognitive reserve against AD progression

BDNF gene expression signals cognitive reserve against AD progression

Brain-derived neurotrophic factor gene expression contributes to slowing of cognitive decline in older adults and may protect against the effects of Alzheimer’s disease pathology, researchers report in Neurology. [More]
New article provides guidance on managing critically ill patients at risk for alcohol withdrawal

New article provides guidance on managing critically ill patients at risk for alcohol withdrawal

Alcohol withdrawal adds challenges to caring for critically ill patients, and nurses must be diligent at each stage of care to minimize complications, according to an article in the February issue of Critical Care Nurse. [More]
Biochemical compound demonstrates increasing potential for use in cancer imaging

Biochemical compound demonstrates increasing potential for use in cancer imaging

In the paper, an international team reviewed studies conducted over the past 30 years on a particular tracer, called “18F-FLT,” and found that it has the potential to improve diagnostic imaging, and thus treatment, of some cancers. [More]
New technology could help identify, characterize biologically active molecules produced by living cells

New technology could help identify, characterize biologically active molecules produced by living cells

Gene sequencing company Illumina recently made big waves by announcing a new spinoff, Grail, dedicated to building a test for cancer by sequencing tumor DNA fragments found in blood. The company also reported plans for a separate project to identify single cells and tag them for later analysis. [More]
Research offers novel insights into root causes of schizophrenia

Research offers novel insights into root causes of schizophrenia

Schizophrenia is a mysterious and devastating disorder that afflicts one percent of the adult population worldwide. Its symptoms — hallucinations, emotional withdrawal, and cognitive impairment — are chronic and typically emerge just as individuals are entering adulthood. Today's medications treat just one of these symptoms (psychosis); treatments for the underlying disease and its many other symptoms have been hard to develop, because no one really understands what causes the disorder. [More]
New partnership aims to study underlying neurobiology and genetics of PTSD, TBI

New partnership aims to study underlying neurobiology and genetics of PTSD, TBI

Cohen Veterans Bioscience today announced two new collaborative partnership efforts that will provide critical research tools for understanding the underlying neurobiology and genetics of post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI) with the goal of accelerating the development of first generation diagnostics and treatments. [More]
UCL-led researchers find way to assess viability of induced pluripotent stem cells

UCL-led researchers find way to assess viability of induced pluripotent stem cells

A research team led by scientists from UCL have found a way to assess the viability of 'manufactured' stem cells known as induced pluripotent stem cells (iPSCs). Published today in Nature Communications, the team's discovery offers a new way to fast-track screening methods used in stem cell research. [More]
New prognostic biomarker may help determine risk of prostate cancer-related death

New prognostic biomarker may help determine risk of prostate cancer-related death

Researchers at the University of Copenhagen have identified a new prognostic biomarker: the neuropeptide pro-NPY, which may help determine the risk of dying from prostate cancer. This particular type of protein is very specific to prostate cancer cells and could help identify whether newly diagnosed patients require radical prostatectomy surgery or if it is safe to delay surgery. [More]
Quest Diagnostics to offer in vitro diagnostic test for use in detection of PD-L1 expression for melanoma

Quest Diagnostics to offer in vitro diagnostic test for use in detection of PD-L1 expression for melanoma

Quest Diagnostics, the world’s leading provider of diagnostic information services, today announced it will offer clinical laboratory testing using the PD-L1 IHC 28-8 pharmDx qualitative test from Dako, an Agilent Technologies company. [More]
ROCA Test now available in nine additional U.S. states for early detection of ovarian cancer

ROCA Test now available in nine additional U.S. states for early detection of ovarian cancer

Abcodia, a commercial stage company focused on the development of proprietary tests for the early detection of cancer, today announced expanded U.S. availability of the ROCA Test. [More]
Colon cancer patients lacking CDX2 protein more likely to benefit from chemotherapy

Colon cancer patients lacking CDX2 protein more likely to benefit from chemotherapy

Using a new computer science approach, researchers at University of California, San Diego School of Medicine, Columbia University and Stanford University discovered a distinctive molecular feature — a biomarker — that identified colon cancer patients who were most likely to remain disease-free up to five years after surgery. [More]
Researchers identify biomarkers that may influence potential new drug design or alternative treatments of cancer

Researchers identify biomarkers that may influence potential new drug design or alternative treatments of cancer

Researchers have discovered gene-targets (biomarkers) that may enable alternative treatments or the potential design of new drugs that target metastasis-promoting tumor genes. [More]
New study identifies DKK3 as a driver of kidney fibrosis

New study identifies DKK3 as a driver of kidney fibrosis

Chronic kidney disease can develop in response to a variety of insults and is characterized by progressive renal fibrosis and atrophy of kidney tubule. Therapeutic options are limited and the disease is often not detected until later stages. [More]
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