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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.
Surgical repair of mitral valve may provide greater benefit in patients with no symptoms

Surgical repair of mitral valve may provide greater benefit in patients with no symptoms

A new study recently published in the Journal of Thoracic and Cardiovascular Surgery questions whether patients with isolated moderate to severe mitral valve regurgitation should receive treatment in earlier stages instead of waiting until symptoms appear. [More]
New MRI method detects low zinc levels to help identify healthy prostate tissue from cancer

New MRI method detects low zinc levels to help identify healthy prostate tissue from cancer

A novel MRI method that detects low levels of zinc ion can help distinguish healthy prostate tissue from cancer, UT Southwestern Medical Center radiologists have determined. [More]
Low selenium levels linked to liver cancer risk? An interview with Dr David Hughes

Low selenium levels linked to liver cancer risk? An interview with Dr David Hughes

Food provides us with a variety of substances we need to maintain life. These substances are essential nutrients and are classified as macronutrients (water, protein, fats, and carbohydrates) and micronutrients (vitamins and minerals). [More]
Study examines psychological impact of tumor gene testing in subset of NCI-MATCH patients

Study examines psychological impact of tumor gene testing in subset of NCI-MATCH patients

The ECOG-ACRIN Cancer Research Group has received federal approval to add a quality-of-life research study, COMmunication and Education in Tumor Profiling (EAQ152) or 'COMET' to the NCI-MATCH (EAY131) trial, already underway. [More]
New NIST Standard Reference Material helps ensure accurate measurements of HER2 breast cancer gene

New NIST Standard Reference Material helps ensure accurate measurements of HER2 breast cancer gene

A new measurement standard developed by the National Institute of Standards of Technology has been used successfully by the Frederick National Laboratory for Cancer Research to check the performance of next-generation DNA-sequencing technologies for evaluating gene variations associated with an increased risk of breast cancer. [More]
Scientists examine how neural responses change over time in patients with Parkinson's disease

Scientists examine how neural responses change over time in patients with Parkinson's disease

Neuroscientists peered into the brains of patients with Parkinson's disease and two similar conditions to see how their neural responses changed over time. [More]
Scientists develop novel method to widen usage of blood in biomarker discovery and analysis

Scientists develop novel method to widen usage of blood in biomarker discovery and analysis

Scientists at Karolinska Institutet in collaboration with Estonian Competence Centre on Health Technologies have developed a new gene expression analysis method to widen the usage of blood in biomarker discovery and analysis. Their paper is published in the journal Scientific Reports. [More]
Study shows microRNA molecule prevents cancer cells from responding to chemotherapy treatment

Study shows microRNA molecule prevents cancer cells from responding to chemotherapy treatment

Annually about 2000 Danish patients with colorectal cancer are treated with chemotherapy. Today, a range of different chemotherapeutic regimens are available. However, deciding which regimen to use is not easy. [More]
New, non-invasive way to monitor progression of Parkinson's disease may help improve treatment

New, non-invasive way to monitor progression of Parkinson's disease may help improve treatment

A new, non-invasive way to track the progression of Parkinson's disease could help evaluate experimental treatments to slow or stop the disease's progression. [More]
BCL-2 inhibitor shows promise in AML patients

BCL-2 inhibitor shows promise in AML patients

Patients whose acute myelogenous leukemia (AML) had relapsed or was resistant to chemotherapy and those who were deemed unable to tolerate chemotherapy experienced responses to the selective BCL-2 inhibitor venetoclax (Venclexta), with complete remissions in some, according to phase II clinical trial data. [More]
Gut microbiome can influence common dietary compound linked to heart disease

Gut microbiome can influence common dietary compound linked to heart disease

In the last five years, some scientists have cautioned against eating eggs and meat because these foods generate a common dietary compound, trimethylamine N-oxide (TMAO), that research has suggested plays a role in heart disease. [More]
Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Immune response measured in tumor biopsies during the course of early treatment predicts which melanoma patients will benefit from specific immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in the journal Cancer Discovery. [More]
Integration of multiple types of protein biomarkers improves ability to detect breast cancer

Integration of multiple types of protein biomarkers improves ability to detect breast cancer

A first-time study published in PLOS ONE shows that a combined assessment of multiple types of protein biomarkers in the blood offers an important advancement for detecting early breast cancer. [More]
New research could lead to improved treatment for depression

New research could lead to improved treatment for depression

SCIENTISTS at the University of Huddersfield led by Dr Patrick McHugh have embarked on a project that could lead to a more effective treatment for depression. [More]
Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Researchers uncover how GWAS-implicated gene affects HDL-cholesterol levels

Researchers have uncovered how genes identified from genome-wide association studies (GWAS) affect high-density lipoprotein cholesterol (HDL-C), a biomarker of cardiovascular disease, after comparing several animal models with human patient data. [More]
ISU researchers discover protein that appears to predict memory loss, brain atrophy in Alzheimer's patients

ISU researchers discover protein that appears to predict memory loss, brain atrophy in Alzheimer's patients

Iowa State University researchers have identified a protein essential for building memories that appears to predict the progression of memory loss and brain atrophy in Alzheimer's patients. [More]
New biochip test helps identify individuals at increased risk of Alzheimer's disease

New biochip test helps identify individuals at increased risk of Alzheimer's disease

Researchers today unveiled results from a new blood test to help identify which patients are at an elevated risk of Alzheimer's disease. [More]
Rice University bioengineer receives NIH grant to study use of AAV-based therapy to combat ovarian cancer

Rice University bioengineer receives NIH grant to study use of AAV-based therapy to combat ovarian cancer

Rice University bioengineer Junghae Suh has been awarded a prestigious R01 grant by the National Institutes of Health to research the use of viral gene therapy to fight ovarian cancer. [More]
Oxford researchers developing new automated system for easier, cheaper diagnosis of pneumonia

Oxford researchers developing new automated system for easier, cheaper diagnosis of pneumonia

Oxford researchers are developing a tool to make it much easier and cheaper to diagnose pneumonia -- the number one killer of children under 5. Their latest research is published in Journal of the Royal Society Interface. [More]
Study creates comprehensive list of blood biomarkers relevant for early detection of cancer

Study creates comprehensive list of blood biomarkers relevant for early detection of cancer

Researchers have identified 788 biomarkers in blood that could be used to develop an early stage cancer screening test for the general population. [More]
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