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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.
Genetic markers may predict tumor samples that respond to treatment

Genetic markers may predict tumor samples that respond to treatment

Patients with chronic myelomonocytic leukemia have limited treatment options, and those that exist are effective only in fewer than half of patients. Now, a new study identifies a panel of genetic markers that predicted which tumor samples would likely respond to treatment. [More]
Patient with severe Alzheimer's shows promising benefits during treatment with Bryostatin drug

Patient with severe Alzheimer's shows promising benefits during treatment with Bryostatin drug

Researchers at the Blanchette Rockefeller Neurosciences Institute and the Marshall University Joan C. Edwards School of Medicine announced their findings from a new study entitled, "PSEN1 Variant in a Family with Atypical AD." An Alzheimer patient with very severe disease, genetically confirmed to have a known variant of PSEN1, showed promising benefits during treatment with the drug Bryostatin 1. [More]
Caris Life Sciences study may have potentially significant benefit in patients with uterine cancer

Caris Life Sciences study may have potentially significant benefit in patients with uterine cancer

Caris Life Sciences today announced the presentation of a study that found drugs targeting specific pathways may have potentially significant benefit in a select subset of patients with uterine cancer. The study results were highlighted today in an oral presentation in a Plenary Session at the Society of Gynecologic Oncology 2015 Annual Meeting on Women's Cancer in Chicago, Ill. [More]
UCLA-led team validates first standardized protocol for tracking early signs of Alzheimer's disease

UCLA-led team validates first standardized protocol for tracking early signs of Alzheimer's disease

After six years of painstaking research, a UCLA-led team has validated the first standardized protocol for measuring one of the earliest signs of Alzheimer's disease -- the atrophy of the part of the brain known as the hippocampus. [More]
Immunomagnetic assay with microfluidic technology can capture, manipulate circulating tumor cells

Immunomagnetic assay with microfluidic technology can capture, manipulate circulating tumor cells

To quantify rare tumor markers that will allow oncologists to make prognoses and select therapies, John X.J. Zhang, PhD led a team of bioengineers from the Thayer School of Engineering at Dartmouth in demonstrating a novel system that couples nano-engineered particles and microfluidic chips for capturing and manipulating circulating tumor cells (CTCs). [More]
The fight continues to end tuberculosis

The fight continues to end tuberculosis

Today is World TB Day. The Centenary Institute is one of the leading medical research institutes in Australia championing the fight to put an end to this insidious disease. [More]
Newly identified proteins could shed light on the mechanisms of ALS

Newly identified proteins could shed light on the mechanisms of ALS

Where ALS comes from and how it progresses are mysteries that continue to vex medical science. But recent research at Sweden's KTH Royal Institute of Technology has found three proteins that could shed some light on the mechanisms behind this deadly disease. [More]
Low zinc levels in older adults correspond with increased chronic inflammation

Low zinc levels in older adults correspond with increased chronic inflammation

Zinc, an important mineral in human health, appears to affect how the immune system responds to stimulation, especially inflammation, new research from Oregon State University shows. [More]
Shp2 enzyme blocks protection program, boosts tumor growth

Shp2 enzyme blocks protection program, boosts tumor growth

Cells have two different programs to safeguard them from getting out of control and developing cancer. One of them is senescence (biological aging). It puts cancer cells into a permanent sleep so they no longer divide and grow in an uncontrolled way. [More]
Discovery raises potential of blood test that can help diagnose osteoarthritis, rheumatoid

Discovery raises potential of blood test that can help diagnose osteoarthritis, rheumatoid

The first blood test for osteoarthritis could soon be developed, thanks to research by the University of Warwick. [More]
Researchers develop noninvasive method to detect kidney cancer early

Researchers develop noninvasive method to detect kidney cancer early

If kidney cancer is diagnosed early — before it spreads — 80 percent of patients survive. However, finding it early has been among the disease's greatest challenges. [More]
New MRI technique from NIST may help diagnose TBI in U.S. veterans

New MRI technique from NIST may help diagnose TBI in U.S. veterans

More than 300,000 U.S. veterans have been diagnosed with traumatic brain injury (TBI) in recent years, a legacy of the Iraq and Afghanistan wars. But these numbers don't tell the whole story. While severe TBI can be obvious, milder cases involving symptoms such as memory loss or inability to concentrate are difficult to confirm and treat. [More]
AbbVie signs exclusive worldwide license agreement with C2N for Alzheimer's disease therapies

AbbVie signs exclusive worldwide license agreement with C2N for Alzheimer's disease therapies

AbbVie today announced that it has entered into an exclusive worldwide license agreement with C2N Diagnostics, a privately held protein diagnostic and therapeutic discovery company, to develop and commercialize a portfolio of anti-tau antibodies for the treatment of Alzheimer's Disease and other neurological disorders. [More]
Denator's heat-stabilization system preserves lipids at close-to-in vivo-levels

Denator's heat-stabilization system preserves lipids at close-to-in vivo-levels

Denator AB announced today that the company’s heat-stabilization system has been demonstrated to preserve lipids at close-to-in vivo-levels. To preserve lipids in a reliable manner prior to mass spectrometry-based analysis is pivotal to accurately quantify and identify potential biomarkers and perform disease research. [More]
Astute Medical hails launch of collaborative global initiative to prevent deaths from AKI by 2025

Astute Medical hails launch of collaborative global initiative to prevent deaths from AKI by 2025

Astute Medical, Inc. today hailed the launch of a collaborative global initiative calling for the elimination of preventable deaths from acute kidney injury (AKI) by 2025. The Company cited the publication of a new Commission from The Lancet and the International Society of Nephrology, along with the release of results from the 0by25 AKI "Global Snapshot" study, as key steps forward in the effort to reduce the global burden of AKI. [More]
CUMC researchers identify mechanism of kidney transplant tolerance

CUMC researchers identify mechanism of kidney transplant tolerance

Columbia University Medical Center researchers have pinpointed the immune system mechanism that allows a kidney transplant to be accepted without lifelong immunosuppressive drugs, a significant step toward reducing or eliminating the need for costly and potentially toxic immunosuppressant drugs and improving long-term transplant success. [More]
Study may help men make better decisions about aggressive prostate cancer treatments

Study may help men make better decisions about aggressive prostate cancer treatments

A Northwestern University-led study in the emerging field of nanocytology could one day help men make better decisions about whether or not to undergo aggressive prostate cancer treatments. [More]
Fast and focused sequencing from single genes to entire exomes

Fast and focused sequencing from single genes to entire exomes

Integrated DNA Technologies (IDT) will host a talk on maximizing efficiency of NGS enrichment panels at the qPCR & NGS 2015 Advanced Molecular Diagnostics for Biomarker Discovery Symposium on Monday March 23rd at 3PM. The talk will detail current technical issues faced by researchers when using hybridization enrichment panels and provide practical advice on how to increase successes while reducing time and costs in targeted sequencing. [More]
Combination of anti-Nodal and DTIC therapy can produce anti-cancer effects

Combination of anti-Nodal and DTIC therapy can produce anti-cancer effects

Metastatic melanoma is the leading cause of skin cancer deaths in the United States; once melanoma has spread (metastasized), life expectancy for patients can be dramatically shortened. [More]
Pressure BioSciences introduces PCT-HD System to global proteomics market

Pressure BioSciences introduces PCT-HD System to global proteomics market

Pressure BioSciences, Inc., a leader in the development and sale of broadly enabling, pressure cycling technology ("PCT")-based sample preparation solutions to the worldwide life sciences industry, today announced the commercial release of the PCT-HD system. [More]
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