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AI algorithms for rare disease diagnosis ignore the genetic, morphological diversity of humans

Up to 40% of rare diseases show facial alterations that enable researchers to identify some pathologies and they can even help them to establish an early diagnosis.

10 May 2023

Researchers discover key immune mechanism that helps control inflammatory response to infection

Monash University researchers have discovered a key mechanism in the body's immune system that helps control the inflammatory response to infection. The discovery could help pave the way for more targeted therapies in a range of inflammatory conditions, such as autoimmunity and neuroinflammatory disease.

5 May 2023

Unraveling Nature's Complexity with Molecular Imaging

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to Ron Heeran, a speaker at the 2023 James L. Waters Symposium.

From Pittcon 1 May 2023

Researchers develop novel bio-inspired molecules to enhance bone regeneration

People's ability to regenerate bones declines with age and is further decreased by diseases such as osteoporosis.

28 Apr 2023

T cell-mediated recognition of conserved bacterial epitope generates broad immunity

Typically T cells of the immune system respond to a specific feature (antigen) of a microbe, thereby generating protective immunity.

25 Apr 2023

New AI-based method for virtual staining of histopathological tissue samples

Researchers from the University of Eastern Finland, the University of Turku, and Tampere University have developed an artificial intelligence-based method for virtual staining of histopathological tissue samples as a part of the Nordic ABCAP consortium. Chemical staining has been the cornerstone of studying histopathology for more than a century and is widely applied in, for example, cancer diagnostics.

18 Apr 2023

New AI tool accurately predicts aggressiveness of colorectal cancer

A new artificial intelligence model designed by researchers at Harvard Medical School and National Cheng Kung University in Taiwan could bring much-needed clarity to doctors delivering prognoses and deciding on treatments for patients with colorectal cancer, the second deadliest cancer worldwide.

13 Apr 2023

Dietary supplement N-acetylcysteine helps overcome treatment resistance in breast cancer

Many cancer therapies do not produce the hoped-for results. A common reason for this is that the tumors develop resistance to the medication.

11 Apr 2023

Endothelial deletion of the Wt1 gene affects coronary vessel formation and myocardial development

How is the mammals' heart formed? What role do endothelial cells play? Do the same pathways and genes involved in the formation of the embryonic heart also play a role in repair processes?

4 Apr 2023

Researchers develop new method to make rare cell types and disease patterns visible in tissue

The human body contains more than 30 trillion cells. Until recently, the sheer number of cells in the organism meant that approaches to understanding human diseases and developmental processes based on the analysis of single cells were a futuristic vision.

31 Mar 2023

New microfluidic device quickly and automatically predicts the effectiveness of cancer treatment

One of the great challenges in the fight against cancer is to design new technologies for a personalized treatment for each patient.

31 Mar 2023

Nuclear medicine brain imaging can help evaluate the biological changes that cause chemo-brain

A newly published literature review sheds light on how nuclear medicine brain imaging can help evaluate the biological changes that cause chemotherapy-related cognitive impairment (CRCI), commonly known as chemo-brain.

28 Mar 2023

Researchers discover a new role for one of the genes linked to hereditary spastic paraplegia

Researchers from the University of Seville and the Seville Institute of Biomedicine (IBiS), in collaboration with the University of Cambridge, have identified a new role for one of the genes related to hereditary spastic paraplegia.

27 Mar 2023

Researchers discover a new switching point that regulates hemostasis and thrombosis

The glycoprotein V of the blood platelets is an important switch point for hemostasis and thrombus formation. This new finding could have great clinical potential.

24 Mar 2023

Molecular mechanism involved in the development of type 2 diabetes discovered

Type 2 diabetes is a chronic disease in which the body does not produce enough insulin, or does not use it efficiently.

23 Mar 2023

How the structural and functional effects of mutations on androgen receptor lead to prostate cancer

The androgen receptor is a key transcriptional factor for the proper sex development —specially in males— and the physiological balance of all the tissues that express this receptor.

17 Mar 2023

Research examines the use of Brillouin microscopy to improve acquisition speed, reduce irradiation doses

Diagnostic imaging offers physicians and scientists critical visual representations of internal body structures, greatly enhancing clinical analysis and medical intervention.

10 Mar 2023

Study creates a radical new view of how immune cells recognize threats

Researchers have created a radical new view of how immune cells recognise threats such as viruses. The discovery could be used to design better vaccines and to gain a deeper insight into autoimmune diseases and allergies.