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Zinc deficiency can activate Hedgehog signaling pathway

Zinc deficiency can activate Hedgehog signaling pathway

Zinc deficiency - long associated with numerous diseases, e.g. autism, lung cancer, prostate cancer, and ovarian cancers - can lead to activation of the Hedgehog signaling pathway, a biomolecular pathway that plays essential roles in developing organisms and in diseases, according to new research at Rensselaer Polytechnic Institute. [More]
Baxter submits BAX 855 NDA to Japan's MHLW for treatment of hemophilia A patients

Baxter submits BAX 855 NDA to Japan's MHLW for treatment of hemophilia A patients

Nektar Therapeutics reported today that partner Baxter International Inc. announced that the company has submitted a new drug application (NDA) to Japan's Ministry of Health, Labour and Welfare for the approval of BAX 855, an investigational, extended half-life recombinant factor VIII (rFVIII) treatment based on ADVATE [Antihemophilic Factor (Recombinant)] for patients over 12 years of age with hemophilia A. [More]
Autophagy: A new approach to fighting tuberculosis

Autophagy: A new approach to fighting tuberculosis

A new approach to combatting tuberculosis would take advantage of a complex, natural process called autophagy that the human body uses to recycle nutrients, remove damaged cell components, eliminate invading bacteria, and respond to inflammation. [More]
NIST researchers develop new 2D NMR fingerprinting method to measure monoclonal antibodies

NIST researchers develop new 2D NMR fingerprinting method to measure monoclonal antibodies

National Institute of Standards and Technology researchers at the Institute for Bioscience and Biotechnology Research have demonstrated the most precise method yet to measure the structural configuration of monoclonal antibodies (mAbs), an important factor in determining the safety and efficacy of these biomolecules as medicines. [More]
India and Canada announce funding to improve maternal, child health in India

India and Canada announce funding to improve maternal, child health in India

Grand Challenges Canada, funded by the Government of Canada, and the Grand Challenges India initiative of the Department of Biotechnology, Government of India, today announced an investment of $2.5 million (CAD) in five health innovations in India. [More]
New herbal tea to treat malaria in Africa

New herbal tea to treat malaria in Africa

Malaria is a critical health problem in West Africa, where traditional medicine is commonly used alongside modern healthcare practices. An herbal remedy derived from the roots of a weed, which was traditionally used to alleviate malarial symptoms, was combined with leaves and aerial portions from two other plants with antimalarial activity, formulated as a tea, and eventually licensed and sold as an antimalarial phytomedicine. [More]
Pivotal enters into sales, distribution agreement for BeneFishial family of products

Pivotal enters into sales, distribution agreement for BeneFishial family of products

Pivotal Therapeutics Inc., a specialty pharmaceutical company with a focus on Omega-3 therapies for cardiovascular disease and overall health, announced today that it has entered into a Memorandum of Understanding with Korea Animal Medical Science Institute and its newly created affiliate for the exclusive sales and distribution of the BeneFishial family of products. [More]

Optibrium to integrate ChemAxon's Plexus with StarDrop software platform

Optibrium and ChemAxon, developers of software and cheminformatics solutions for drug discovery, today announced the results of a collaboration to integrate ChemAxon's Plexus with Optibrium's StarDrop software suite. The integration of these platforms further enables researchers to develop strategies for efficient, high quality compound library design. [More]

Clyde Biosciences announces £2 million ‘Series A’ investment

Clyde Biosciences Ltd. has announced a £2 million ‘Series A’ investment led by Epidarex Capital, a leading international early-stage life science venture capital fund. [More]
A beginner’s guide to CRISPR genome editing

A beginner’s guide to CRISPR genome editing

In a recent DECODED Online entry, Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides an overview of the CRISPR/Cas9 system to scientists looking to enhance their genome modification strategy in model organisms or cell lines. [More]

Clyde Biosciences, a leading drug toxicity testing company, closes Series A investment

Clyde Biosciences Ltd. (Clyde Biosciences) has announced a £2 million ‘Series A’ investment led by Epidarex Capital, a leading international early-stage life science venture capital fund. Scottish Enterprise’s investment arm, the Scottish Investment Bank, also participated in the round along with Glasgow University Holdings, Ltd. [More]
Oxis International resumes trading of common stock on Euronext Paris on April 14, 2015

Oxis International resumes trading of common stock on Euronext Paris on April 14, 2015

Oxis International, Inc., a biotechnology company focused on cancer therapy development and commercialization, announced today that trading in its common stock will resume on Euronext Paris on April 14, 2015. [More]
Fraunhofer researchers develop cell-free substrate made of advanced fibers

Fraunhofer researchers develop cell-free substrate made of advanced fibers

Regenerative medicine uses cells harvested from the patient's own body to heal damaged tissue. Fraunhofer researchers have developed a cell-free substrate containing proteins to which autologous cells bind and grow only after implantation. [More]
New automated tool rapidly delivers large particles into mammalian cells

New automated tool rapidly delivers large particles into mammalian cells

A new device developed by UCLA engineers and doctors eventually help scientists study the development of disease, enable them to capture improved images of the inside of cells and lead to other improvements in medical and biological research. [More]

Special concession on PTI training courses for new and growing life science organisations

Following its recent introduction of innovative game-based e-learning modules, Pharmaceutical Training International (PTI) is providing the opportunity to make substantial savings on its full range of training courses to start-ups and SMEs (with fewer than 50 employees), as well as non-profit organisations and government bodies... [More]
Challenges involved in tracing the source of Legionnaires’ disease outbreak

Challenges involved in tracing the source of Legionnaires’ disease outbreak

Genetic research helps to explain why tracing the source of an outbreak of Legionnaires' disease that claimed four lives has proven to be more complicated than scientists hoped. [More]
Hedione scent generates sex-specific activation patterns in brain

Hedione scent generates sex-specific activation patterns in brain

The question if humans can communicate via pheromones in the same way as animals is under debate. Cell physiologists at the Ruhr-Universität Bochum have demonstrated that the odorous substance Hedione activates the putative pheromone receptor VN1R1, which occurs in the human olfactory epithelium. [More]
Nielsen BioSciences launches skin test that helps physicians manage Valley Fever infections

Nielsen BioSciences launches skin test that helps physicians manage Valley Fever infections

Nielsen BioSciences announced today the launch of SPHERUSOL (Coccidioides immitis Spherule-Derived Skin Test Antigen), a skin test that provides valuable data to physicians managing Valley Fever infections. SPHERUSOL has been approved by the U.S. Food and Drug Administration as the only skin test to detect an immune response to the fungus called Coccidioides, or "cocci," in patients with history of the disease. [More]
UAB scientists create alternative to the use of viruses in gene therapy

UAB scientists create alternative to the use of viruses in gene therapy

A team of scientists from the Institute for Biotechnology and Biomedicine at the UAB has produced an alternative to the use of viruses in gene therapy. The researchers synthesised nanoparticles which act as artificial viruses, capable of surrounding DNA fragments and releasing them as therapeutic agents, with no biological risk, into the interior of the cells. [More]
New study describes economic consequences of using T2Candida Panel for detection of candidemia

New study describes economic consequences of using T2Candida Panel for detection of candidemia

A new study describes a model that estimates the economic consequences of using the T2Candida Panel (a novel diagnostic product that provides Candida detection) as an adjunct to the current blood culture-based diagnostic strategy in a high-risk hospital patient cohort. [More]
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