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FDA accepts Mundipharma EDO's Investigational New Drug Application for EDO-S101

FDA accepts Mundipharma EDO's Investigational New Drug Application for EDO-S101

Mundipharma EDO GmbH (Early Development in Oncology) is pleased to announce that the United States Food and Drug Administration has accepted the company's Investigational New Drug Application ("IND") for EDO-S101, a fusion molecule to treat relapsed/refractory haematologic malignancies and solid tumours. [More]
Eisai, Halozyme partner to evaluate eribulin and PEGPH20 in HER2-negative metastatic breast cancer

Eisai, Halozyme partner to evaluate eribulin and PEGPH20 in HER2-negative metastatic breast cancer

Eisai Inc. announced today that its parent company Eisai Co., Ltd. (Headquarters: Tokyo, President and CEO: Haruo Naito) and Halozyme Therapeutics, Inc. (Headquarters: San Diego, California, President and CEO: Dr. Helen Torley) have signed a clinical collaboration agreement to evaluate Eisai's agent eribulin mesylate (brand name: Halaven, "eribulin") in combination with Halozyme's investigational drug PEGPH20 (PEGylated recombinant human hyaluronidase) in first line HER2-negative metastatic breast cancer. [More]
IDIBELL licenses a tool to Oxford Immunotec to improve efficiency of kidney transplants, prevent graft rejection

IDIBELL licenses a tool to Oxford Immunotec to improve efficiency of kidney transplants, prevent graft rejection

The Bellvitge Biomedical Research Institute has licensed to the company Oxford Immunotec, a technology to measure the secretion of anti-HLA antibodies from memory B cells to improve the efficiency of kidney transplants and prevent rejection of graft. [More]
New non-invasive spinal cord stimulation helps paralyzed men voluntarily move their legs

New non-invasive spinal cord stimulation helps paralyzed men voluntarily move their legs

Five men with complete motor paralysis were able to voluntarily generate step-like movements thanks to a new strategy that non-invasively delivers electrical stimulation to their spinal cords, according to a new study funded in part by the National Institutes of Health. The strategy, called transcutaneous stimulation, delivers electrical current to the spinal cord by way of electrodes strategically placed on the skin of the lower back. [More]
Study reveals how brain work leads to physical fatigue

Study reveals how brain work leads to physical fatigue

Do you ever notice how stress and mental frustration can affect your physical abilities? When you are worried about something at work, do you find yourself more exhausted at the end of the day? This phenomenon is a result of the activation of a specific area of the brain when we attempt to participate in both physical and mental tasks simultaneously. [More]
New blood test could help diagnose severity of traumatic brain injury

New blood test could help diagnose severity of traumatic brain injury

A new blood test could help emergency room doctors quickly diagnose traumatic brain injury and determine its severity. [More]
New Penn study questions relevance of fish oil-derived SPMs and their anti-inflammatory effects in humans

New Penn study questions relevance of fish oil-derived SPMs and their anti-inflammatory effects in humans

The importance of a diet rich in fish oils - now a billion dollar food-supplement industry -- has been debated for over half a century. A few large clinical trials have supported the idea that fish oils confer therapeutic benefits to patients with cardiovascular disease. Researchers think that hearts and blood vessels may benefit in part from their anti-inflammatory properties. [More]
IUPUI researchers receive NIH grant to study effect of depression treatment on cardiovascular disease

IUPUI researchers receive NIH grant to study effect of depression treatment on cardiovascular disease

Indiana University-Purdue University Indianapolis researchers led by Jesse Stewart of the School of Science, have received a $2.6 million grant from the National Institutes of Health to conduct the first randomized controlled trial to determine whether depression treatment can help prevent the development of cardiovascular disease. [More]
Psychotropic medication use widespread among older adults, new study finds

Psychotropic medication use widespread among older adults, new study finds

Older Americans receive prescriptions for mental health medications at more than twice the rate that younger adults do, a new study finds. [More]
Pharmacist-included medical care teams help patients better control blood pressure

Pharmacist-included medical care teams help patients better control blood pressure

If you have hypertension, it pays to include a pharmacist in a medical care team. That's the upshot from research by the University of Iowa that found patients with uncontrolled hypertension had better blood pressure control when being cared for by pharmacists working in care teams (with a physician, for example) than patients who relied mostly on a doctor for medication guidance. [More]
Study shows link between liver-produced molecules, pneumonia susceptibility during sepsis

Study shows link between liver-produced molecules, pneumonia susceptibility during sepsis

New evidence highlights the importance of the liver in immunity against bacterial pneumonia. The study is the first of its kind to directly show such a link between liver-produced molecules and pneumonia susceptibility during sepsis. [More]
Cryoport to offer cryogenic logistics solutions to HemaCare

Cryoport to offer cryogenic logistics solutions to HemaCare

Cryoport, Inc., the leading provider of advanced cryogenic logistics solutions for the life sciences industry, serving markets including immunotherapies, stem cells, cell lines, clinical research organizations, vaccine manufacturers, animal health, and reproductive medicine, today announced that the Company will provide cryogenic logistics solutions to HemaCare Corporation, a leading global provider of high-quality biological material to the scientific community. [More]
Surgeons describe positive outcomes in kidney cancer patients treated with robotic IVC thrombectomy

Surgeons describe positive outcomes in kidney cancer patients treated with robotic IVC thrombectomy

Surgery is required when cancer of the kidney causes a Level III thrombus, or clot, to develop in the major vein leading back to the heart. Traditionally this complicated procedure, inferior vena cava (IVC) thrombectomy, is performed using a large open incision, primarily because the vein is often difficult to reach. [More]
Balancing cellular aging and cancer risk through biotechnology

Balancing cellular aging and cancer risk through biotechnology

In a way, trying to repair age-related heart damage and trying to fight cancer are opposite problems. Your heart cells' ability to regenerate themselves and proliferate into new, young cells degrades as you get older. [More]
New national survey finds lack of COPD knowledge among patients

New national survey finds lack of COPD knowledge among patients

In a new national survey of chronic obstructive pulmonary disease (COPD) patients, Health Union reveals a surprising lack of awareness of risk factors and knowledge of diagnosis stage among patients. Results demonstrate a severe impact on quality of life, employment, and ability to afford treatment. [More]
New research shows promising progress in use of anti-inflammatory cytokine for T1D treatment

New research shows promising progress in use of anti-inflammatory cytokine for T1D treatment

New research from Uppsala University shows promising progress in the use of anti-inflammatory cytokine for treatment of type 1 diabetes. The study, published in the open access journal Scientific Reports (Nature Publishing Group), reveals that administration of interleukin-35 (a protein made by immune cells) to mice with type 1 diabetes, reverses or cures the disease by maintaining a normal blood glucose level and the immune tolerance. [More]
Commonly prescribed drug also lowers blood pressure when combined with diuretic

Commonly prescribed drug also lowers blood pressure when combined with diuretic

With the growth of electronic medical records, research utilizing data from a large number of patients, known as big data studies, can provide important information which may be unattainable via clinical trials which tend to be costly, time-consuming and involve fewer patients. [More]
Bioenergetic analysis of pancreatic beta-cells shows impaired metabolic signature in type 2 diabetes patients

Bioenergetic analysis of pancreatic beta-cells shows impaired metabolic signature in type 2 diabetes patients

Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes. The cause of this dysfunction has been unknown. Publishing online in Endocrinology, Buck Institute assistant research professor Akos Gerencser, PhD, shows that in patients with type 2 diabetes the balance between supply and demand of the mitochondrial membrane potential (ΔψM) is altered causing a decrease in the signaling that turns on insulin secretion. [More]
Astellas reports topline results from isavuconazole Phase 3 study in candidemia and other invasive Candida infections

Astellas reports topline results from isavuconazole Phase 3 study in candidemia and other invasive Candida infections

Astellas today announced topline results from the Phase 3 ACTIVE study evaluating the efficacy and safety of intravenous (IV) and oral isavuconazole, commercially known as CRESEMBA (isavuconazonium sulfate), under development for adults with candidemia and other invasive Candida infections. [More]

New set of clinical practice guidelines released to address temperature management during open heart surgery

The Society of Thoracic Surgeons, the Society of Cardiovascular Anesthesiologists, and the American Society of ExtraCorporeal Technology have released a set of clinical practice guidelines to address management of a patient's temperature during open heart surgery. The guidelines appear in the August issue of The Annals of Thoracic Surgery and were published simultaneously in two other journals. [More]
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