Bone Morphogenetic Protein News and Research

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Penn researchers discover gene that creates "second skeleton" bone disorder

Researchers at the University of Pennsylvania School of Medicine have located the "skeleton key," a gene that, when damaged, causes the body's skeletal muscles and soft connective tissue to undergo a metamorphosis into bone, progressively locking joints in place and rendering movement impossible.

23 Apr 2006

Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6

A novel growth factor significantly improves the ability of specialized stem cells derived from human fat to be transformed into cartilage cells, according to Duke University Medical Center and Pratt School of Engineering researchers.

16 Apr 2006

Delicate balance of induction and inhibition in determining tooth cusps

One of the remaining challenges for evolutionary developmental studies of mammals, whose evolution is best known from their teeth, is how their tooth shape is altered during development.

26 Sep 2005

Study points to link to neurodegenerative disease target

A University of California - San Francisco (UCSF) study has found that a specific signaling link between neurons and muscles in the fruit fly is essential for keeping the insect's nervous system stable.

1 Sep 2005

Advance in genetics of cleft lip and palate

Cleft lip and/or palate remains one of the most common birth defects in the world. It occurs when the sides of the face fuse abnormally in a developing baby, resulting in a malformed lip and/or roof of the mouth.

12 Apr 2005

Potential therapeutic target for infertility and contraception

The multiple “litter” births of mice, versus the normal singleton pregnancy of humans, is due to defective processing in mice of a common mammalian protein called bone morphogenetic protein 15 (BMP-15), according to new research from the University of California, San Diego (UCSD) School of Medicine.

5 Apr 2005

Important link between kidney damage and cardiac problems

Scientists have identified an important link between kidney damage and cardiac problems, creating new possibilities for treating the primary cause of death in kidney disease patients.

29 Mar 2005

Gene linked to bone mineral density

Sequenom has announced the discovery of a genetic variation in the gene encoding phosphodiesterase 4D (PDE4D) that is believed to affect osteoporosis risk. Fragility fractures caused by osteoporosis are a major cause of morbidity and mortality in the aging population.

23 Mar 2005

Overlapping signals in embryo help get the backbone right

A major step in the development of the vertebrate embryo - the establishment of a back that morphs into a brain, spinal cord and muscles - turns out to be so important that the body uses at least three signals to make sure it happens properly.

9 Mar 2005

Gene therapy helps generate bone around dental implants

A University of Michigan research team has found that introducing a growth factor protein into a mouth wound using gene therapy helped generate bone around dental implants, according to a new paper in the February issue of the journal Molecular Therapy.

3 Feb 2005

Surgeons remodel and replace man's jaw bone allowing him to eat first dinner in 9 years

“By the 4th week post-transplantation the patient enjoyed his first dinner in 9 years (bread and sausages); before reconstruction he had only been able to eat soft food and soup”.

26 Aug 2004

$FDA approves INFUSE® bone graft which improves fracture healing$

FDA approves INFUSE® bone graft which improves fracture healing

Medtronic, Inc. has announced that the U.S. Food and Drug Administration (FDA) approved the use of INFUSE® Bone Graft in the treatment of acute, open fractures of the tibial shaft, a long bone in the lower leg. The approval broadens the indications for INFUSE Bone Graft, a product that has been used since 2002 in spinal surgery with metallic cages to treat tens of thousands of patients.

4 May 2004

Wyeth gets FDA approval for a novel protein device that enhances bone healing

Wyeth have announced that the FDA has approved rhBMP-2/ACS (recombinant human Bone Morphogenetic Protein-2/Absorbable Collagen Sponge), a novel protein device that enhances bone healing, for use in the treatment of acute, open tibia shaft fractures in adults.

3 May 2004