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Characterizing the brain, cell by cell

Characterizing the brain, cell by cell

My group develops approaches to study cell-to-cell signaling in the brain – how the cells of the brain talk to each other. The brain is heterogeneous, probably more so than any other organ in our body, and many of its functions depend on the unique characteristics of these cells. [More]
New way of repurposing existing drugs could unearth promising treatments for Parkinson’s disease

New way of repurposing existing drugs could unearth promising treatments for Parkinson’s disease

By bringing together cutting-edge stem cell technologies and computational biology, researchers at Oxford University have developed a unique way to identify existing drugs that could potentially be repurposed for treating Parkinson’s. [More]
New ‘5-D fingerprint’ technique could precisely measure properties of individual protein molecules

New ‘5-D fingerprint’ technique could precisely measure properties of individual protein molecules

In research that could one day lead to advances against neurodegenerative diseases like Alzheimer's and Parkinson's, University of Michigan engineering researchers have demonstrated a technique for precisely measuring the properties of individual protein molecules floating in a liquid. [More]
Researchers identify brain cell types from cell culture of adult human neurons

Researchers identify brain cell types from cell culture of adult human neurons

Studying brain disorders in people and developing drugs to treat them has been slowed by the inability to investigate single living cells from adult patients [More]
Onset of hypertension later in life linked to lower dementia risk, study finds

Onset of hypertension later in life linked to lower dementia risk, study finds

New study results published online today in Alzheimer's & Dementia: The Journal of the Alzheimer's Association suggest that onset of high blood pressure later in life is associated with lower dementia risk after age 90, especially if hypertension is developed at age 80 or older. [More]
Scientists identify molecular pathway in the brain that may help find better treatments for dementia

Scientists identify molecular pathway in the brain that may help find better treatments for dementia

Rutgers University scientists have discovered a molecular pathway in the brain that may help provide answers to long-term memory problems in the elderly and aid researchers in identifying drug-based therapies to prevent dementia. [More]
Johns Hopkins researchers identify new biological target for treating spinal muscular atrophy

Johns Hopkins researchers identify new biological target for treating spinal muscular atrophy

Johns Hopkins researchers along with academic and drug industry investigators say they have identified a new biological target for treating spinal muscular atrophy. [More]
Scientists find explanation for vulnerability of children to collateral damage from cancer treatment

Scientists find explanation for vulnerability of children to collateral damage from cancer treatment

Despite many successes in treating pediatric cancer, young children remain at high risk for developing severe, long-lasting impairments in their brain, heart, and other vital organs from chemotherapy and radiation treatments. In adults, however, these tissues are relatively spared. [More]
Neurons appear to retain partial communication despite serious structural aberrations, study finds

Neurons appear to retain partial communication despite serious structural aberrations, study finds

Neuroscientists have long known that brain cells communicate with each other through the release of tiny bubbles packed with neurotransmitters—a fleet of vessels docked along neuronal ends ready to launch when a trigger arrives. [More]
Study finds way to detect early signs of AD by looking at retina of patients' eyes

Study finds way to detect early signs of AD by looking at retina of patients' eyes

A new study from The University of Texas Medical Branch at Galveston offers important insight into how Alzheimer's disease begins within the brain. [More]
Bone gene in mammals may take additional role to promote cognition in humans

Bone gene in mammals may take additional role to promote cognition in humans

A gene that regulates bone growth and muscle metabolism in mammals may take on an additional role as a promoter of brain maturation, cognition and learning in human and nonhuman prim ates, according to a new study led by neurobiologists at Harvard Medical School. [More]
Research reveals mechanism behind progression of neurodegenerative diseases in the brain

Research reveals mechanism behind progression of neurodegenerative diseases in the brain

Synapses, the place where brain cells contact one another, play a pivotal role in the transmission of toxic proteins. This allows neurodegenerative diseases such as Alzheimer's to spread through the brain. [More]
Researchers discover genetic alterations in autism gene that reduces brain activity

Researchers discover genetic alterations in autism gene that reduces brain activity

Scientists at McMaster University's Stem Cell and Cancer Research Institute in collaboration with Sick Children's Hospital have discovered genetic alterations in the gene DIXDC1 in individuals with autism spectrum disorders (ASD). [More]
Genetic mutation confers risk for development of Parkinson's disease earlier than usual

Genetic mutation confers risk for development of Parkinson's disease earlier than usual

A collaboration of 32 researchers in seven countries, led by scientists at Mayo Clinic's campus in Florida, has found a genetic mutation they say confers a risk for development of Parkinson's disease earlier than usual. [More]
Takara Bio to provide SMART-Seq v4 Ultra Low Input RNA Kit for Sequencing to Allen Institute

Takara Bio to provide SMART-Seq v4 Ultra Low Input RNA Kit for Sequencing to Allen Institute

Takara Bio USA, Inc. announced today that its SMART-Seq v4 Ultra Low Input RNA Kit for Sequencing has been selected for the development of gene expression profiles of individual brain cells as part of the Allen Cell Types Database, a public resource available from the Allen Institute for Brain Science. [More]
New study to explore therapeutic pill for treatment of concussion

New study to explore therapeutic pill for treatment of concussion

The goal of finding a treatment for concussion may be one step closer due to a new study being launched by University of Miami researchers. [More]
Scientists identify commonly affected genes sets among people with three mental disorders

Scientists identify commonly affected genes sets among people with three mental disorders

Studying brain tissue from deceased donors, Johns Hopkins scientists have found common groups of genes disrupted among people with schizophrenia, bipolar disorder and major depression. [More]
New bionic hybrid neuro chip records brain cell activity at higher resolution

New bionic hybrid neuro chip records brain cell activity at higher resolution

Brain functions are controlled by millions of brain cells. However, in order to understand how the brain controls functions, such as simple reflexes or learning and memory, we must be able to record the activity of large networks and groups of neurons. [More]
UA neuroscientists receive $10.3 million grant to find cause for heightened risk of Alzheimer's in women

UA neuroscientists receive $10.3 million grant to find cause for heightened risk of Alzheimer's in women

Why do more women than men get Alzheimer's disease? In their quest to find the answer, neuroscientist Roberta Diaz Brinton, PhD, and her collegues in the Center for Innovation in Brain Science at the University of Arizona Health Sciences, have been awarded a $10.3 million five-year Program Project Grant from the National Institute on Aging at the National Institutes of Health. [More]
Researchers come together to discuss potential impact of exercise at all stages of life

Researchers come together to discuss potential impact of exercise at all stages of life

Get more exercise. The often-repeated health recommendation is usually prescribed to lose weight or build muscle, but the many health effects of exercise reach far beyond weight and body composition. [More]
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