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Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries

Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries

Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer's. [More]
Immunotherapy already in clinical trials for cancer could slow progression of Parkinson's disease

Immunotherapy already in clinical trials for cancer could slow progression of Parkinson's disease

Researchers at Johns Hopkins report they have identified a protein that enables a toxic natural aggregate to spread from cell to cell in a mammal's brain — and a way to block that protein's action. [More]
Research reveals how Zika virus arrests fetal brain development in pigtail macaque

Research reveals how Zika virus arrests fetal brain development in pigtail macaque

For the first time, abnormal brain development following a Zika infection during pregnancy has been documented experimentally in the offspring of a non-human primate. [More]
Clinical trial to examine effectiveness of diabetes drug to slow or stop progression of Parkinson's

Clinical trial to examine effectiveness of diabetes drug to slow or stop progression of Parkinson's

Type II diabetes and Parkinson's disease may not appear to have much in common but a look below the surface reveals important molecular similarities that provide a potential target for fighting Parkinson's. [More]
New collaborative initiative to develop novel ways of screening drugs for bipolar disorder, schizophrenia

New collaborative initiative to develop novel ways of screening drugs for bipolar disorder, schizophrenia

The Johns Hopkins University School of Medicine and the Salk Institute for Biological Studies will co-lead a $15.4 million effort to develop new systems for quickly screening libraries of drugs for potential effectiveness against schizophrenia and bipolar disorder, the National Institute of Mental Health (NIMH) has announced. [More]
SAGA funding initiative aims to advance understanding of potential sex differences in Alzheimer's

SAGA funding initiative aims to advance understanding of potential sex differences in Alzheimer's

The first-ever Alzheimer's Association Sex and Gender in Alzheimer's research grant awards will provide $2.2 million to nine projects to advance understanding of the disproportionate effect of Alzheimer's disease on women. [More]
NCATS scientists identify promising compounds effective in inhibiting Zika virus replication

NCATS scientists identify promising compounds effective in inhibiting Zika virus replication

Researchers at the National Center for Advancing Translational Sciences recently identified compounds that potentially can be used to inhibit Zika virus replication and reduce its ability to kill brain cells. [More]
Fluid-filled sacs that brain cells make to trap amyloid may contribute to Alzheimer's disease

Fluid-filled sacs that brain cells make to trap amyloid may contribute to Alzheimer's disease

Vesicles, fluid-filled sacs that brain cells make to trap amyloid, a hallmark of Alzheimer's, appear to also contribute to the disease, scientists report. [More]
Skin cells derived from autistic donors grow faster than those from control subjects

Skin cells derived from autistic donors grow faster than those from control subjects

Brain cells grow faster in children with some forms of autism due to distinct changes in core cell signaling patterns, according to research from the laboratory of Anthony Wynshaw-Boris, MD, PhD, chair of the department of genetics and genome sciences at Case Western Reserve University School of Medicine. [More]
Study suggests structural changes in the brain help cope with stressful situations

Study suggests structural changes in the brain help cope with stressful situations

People who experience job loss, divorce, death of a loved one or any number of life's upheavals often adopt coping mechanisms to make the situation less traumatic. [More]
Research findings offer more insight into complexity and robustness of the brain

Research findings offer more insight into complexity and robustness of the brain

The brain is well capable of coping with the erratic way individual brain cells transmit information. [More]
TSRI scientists find evidence supporting new therapeutic strategy against cocaine addiction

TSRI scientists find evidence supporting new therapeutic strategy against cocaine addiction

An international team led by scientists at The Scripps Research Institute has found strong evidence supporting a new strategy against drug addiction. [More]
USC researchers discover two Zika proteins potentially responsible for microcephaly

USC researchers discover two Zika proteins potentially responsible for microcephaly

USC researchers have tracked down two Zika proteins potentially responsible for thousands of microcephaly cases in Brazil and elsewhere — taking one small step toward preventing Zika-infected mothers from birthing babies with abnormally small heads. [More]
Researchers identify reason why antidepressants take so long to work

Researchers identify reason why antidepressants take so long to work

An episode of major depression can be crippling, impairing the ability to sleep, work, or eat. In severe cases, the mood disorder can lead to suicide. But the drugs available to treat depression, which can affect one in six Americans in their lifetime, can take weeks or even months to start working. [More]
Inability to turn off genes in the brain can affect learning and memory

Inability to turn off genes in the brain can affect learning and memory

Every time you play a game of basketball, make a cup of coffee or flick on a light switch, you are turning on genes in your brain. These same genes typically are turned off when the activity ceases - but when that doesn't happen, damaging consequences can occur. [More]
Researchers discover new biological pathway involved in Alzheimer's disease

Researchers discover new biological pathway involved in Alzheimer's disease

Researchers have identified a new biological pathway involved in Alzheimer's disease. In experiments using fruit flies, blocking the pathway reduced the death of brain cells, suggesting that interfering with the pathway could represent a promising new strategy to treat the disease in human patients. [More]
Scientists use stem cell techniques to unravel biology of autism

Scientists use stem cell techniques to unravel biology of autism

The brains of some people with autism spectrum disorder grow faster than usual early on in life, often before diagnosis. [More]
New mouse model reveals how Alzheimer's causes dementia

New mouse model reveals how Alzheimer's causes dementia

Using a novel, newly developed mouse model that mimics the development of Alzheimer's disease in humans, Johns Hopkins researchers say they have been able to determine that a one-two punch of major biological "insults" must occur in the brain to cause the dementia that is the hallmark of the disease. [More]
Scientists provide new insights into role of star-shaped brain cells in memory, learning

Scientists provide new insights into role of star-shaped brain cells in memory, learning

A molecule that enables strong communication between our brain and muscles appears to also aid essential communication between our neurons, scientists report. [More]
Long-term suppression of neurotransmitter acetylcholine may lead to dementia-like changes in the brain

Long-term suppression of neurotransmitter acetylcholine may lead to dementia-like changes in the brain

A new study from Western University is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. [More]
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