Calcification News and Research

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OxThera announces initiation of Oxabact clinical study in Primary Hyperoxaluria

OxThera AB, a Stockholm-based privately-held biopharmaceutical company, today announced that it has initiated a clinical study in Primary Hyperoxaluria. This announcement bolsters the Company's position as a leader in developing therapies for hyperoxaluria, a debilitating condition that, if untreated, leads to kidney damage and end-stage renal disease.

8 Jan 2014

Implanting tubes in ears is less likely to improve long-term cognitive and functional development

Watchful waiting or ear tube surgery? It is a decision faced by millions of families of children with recurrent or chronic otitis media with effusion (non-infected fluid in the middle ear) each year.

6 Jan 2014

Aortic valve implantation does not impair mental capacity of patients

Aortic valve stenosis is the most frequent heart valve defect of older people in Europe - the cause is usually increasing calcification of this important valve. In patients at high and excessive risk, conventional cardiac surgery is often no therapeutic option.

6 Dec 2013

U.S. physicians use CSI's Diamondback 360 Coronary OAS for coronary artery disease treatment

Cardiovascular Systems, Inc., today announced that its new Diamondback 360 Coronary Orbital Atherectomy System is being used by physicians across the country to treat coronary artery disease. This follows the company's recent PMA approval from the U.S. Food and Drug Administration to market the device as a treatment for severely calcified coronary arteries.

3 Dec 2013

‘Pioneering’ non-invasive coronary plaque imaging revealed

Combined 18F-sodium fluoride positron emission tomography–computed tomography allows physicians to visualize high-risk or ruptured coronary atherosclerotic plaques in patients with myocardial infarction or stable angina, research shows.

12 Nov 2013

Allied Healthcare Group commences first shipment of CardioCel into Europe

Allied Healthcare Group today announces it has commenced shipment of CardioCel into Europe after the Company received its first orders for the product from outside of Australia.

8 Nov 2013

Rice U. researchers link von Willebrand factor to heart-valve calcium deposits

Heart valves calcify over time, and Rice University scientists are beginning to understand why. The Rice lab of bioengineer Jane Grande-Allen found through studies of pigs' heart valves that age plays a critical role in the valves' progressive hardening, and the problem may be due to the infiltration of a protein known as von Willebrand factor.

8 Nov 2013

MRI: A valuable tool for assessing risk of heart attack, stroke in diabetic patients

Whole-body MRI may serve as a valuable noninvasive tool for assessing the risk of heart attack and stroke in diabetic patients, according to a new study published online in the journal Radiology.

10 Sep 2013

Aortic stenosis doubles in patients with family history of the condition

Aortic stenosis is the most common heart valve disease in the elderly. It is associated with congenital bicuspid aortic valve and previous rheumatic heart disease, but is also often caused by calcification of a normal valve. Calcification of a normal valve may be associated with atherosclerotic changes in the portion of the aorta closest to the valve.

2 Sep 2013

Study compiles and analyzes data on reaction of marine animals to ocean acidification

Ocean acidification could change the ecosystems of our seas even by the end of this century. Biologists at the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI), have therefore assessed the extent of this ominous change for the first time.

30 Aug 2013

Kidney patients who take calcium to lower phosphorous levels at higher risk of death: Study

Kidney patients who take calcium supplements to lower their phosphorous levels may be at a 22 per cent higher risk of death than those who take other non-calcium based treatments, according to a new study by Women's College Hospital's Dr. Sophie Jamal.

20 Jul 2013

Research shows that rates of coronary heart disease are higher with longer duration of obesity

In a study of adults recruited and followed up over the past 3 decades in the United States, longer duration of overall and abdominal obesity beginning in young adulthood was associated with higher rates of coronary artery calcification, a subclinical predictor of coronary heart disease, according to a study in the July 17 issue of JAMA.

17 Jul 2013

Cancer patients who receive chest radiation should screen for heart disease every 5-10 years

Cancer patients who receive chest radiation should be screened for heart disease every 5-10 years, according to the European Association of Cardiovascular Imaging (EACVI) of the European Society of Cardiology (ESC) and the American Society of Echocardiography (ASE).

17 Jul 2013

Cancer patients who receive chest radiation should be screened for heart disease every 5-10 years

16 Jul 2013

New study identifies possible treatment to block deposition of calcium in arterial wall

HGPS is a rare genetic disease that affects one in every 4-8 million births. The disease is caused by a spontaneous mutation in one of the two copies (alleles) of the gene LMNA, which codes for lamin A, a protein important for the integrity and function of the envelope surrounding the cell nucleus. The mutation causes incorrect processing of the messenger RNA for lamin proteins, resulting in the synthesis of an anomalous protein, called progerin.

18 Jun 2013

OPKO reports more than 50% enrollment in phase 3 trial of Rayaldy for treatment of secondary hyperparathyroidism

OPKO Health, Inc., has surpassed 50% enrollment in the first phase 3 trial of RayaldyTM to treat patients with secondary hyperparathyroidism (SHPT), stage 3 or 4 chronic kidney disease (CKD) and vitamin D insufficiency.

24 May 2013

Study: Air and noise pollution may increase risk of cardiovascular disease

Both fine-particle air pollution and noise pollution may increase a person's risk of developing cardiovascular disease, according to German researchers who have conducted a large population study, in which both factors were considered simultaneously.

21 May 2013

Patients with faulty heart valves can benefit from Valve-in-Valve technique

When a biologic aortic valve prosthesis fails, the patient often faces a high risk valve replacement through repeat open heart surgery. A new technique, known as Valve-in-Valve, uses minimally invasive techniques to introduce a collapsible aortic heart valve into the damaged valve in order to restore function.

7 May 2013

Drug that targets phosphate does not improve CVD measures in patients with mild kidney disease

High phosphate levels in the blood carry increased heart-related risks, but taking a drug that targets phosphate does not improve cardiovascular measures in patients with mild kidney disease, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

19 Apr 2013

Study shows long-term exposure to fine particle matter air pollution is associated with atherosclerosis

The association between road traffic and heart disease has been suggested in several studies. In 2012 a large prospective cohort study from Denmark showed that traffic noise was significantly associated with risk of heart attack - for every 10 decibel increase in noise exposure (either at the time of the attack or over the five years preceding it) there was a 12% increased risk.

18 Apr 2013