The hardening of arteries is a hallmark of atherosclerosis, an often deadly disease in which plaques, excessive connective tissue, and other changes build up inside vessel walls and squeeze off the flow of oxygen-rich blood throughout the body.
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A class of water-loving, jelly-like materials with uses ranges ranging from the mundane, such as superabsorbent diaper liners, to the sophisticated, such as soft contact lenses, could be tapped for a new line of serious work: testing the biological effects of nanoparticles now being eyed for a large variety of uses.
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Sanofi and Regeneron Pharmaceuticals, Inc. today announced that the COMPARE and ASCERTAIN trials of sarilumab, the first fully human monoclonal antibody directed against the IL-6 receptor, which is delivered by subcutaneous injection every other week, have enrolled their first patients.
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Researchers from the RIKEN Center for Integrative Medical Sciences in Japan have identified the first gene to be associated with adolescent idiopathic scoliosis (also called AIS) across Asian and Caucasian populations.
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Scientists have discovered that fat cells in the knee secrete a protein linked to arthritis, a finding that paves the way for new gene therapies that could offer relief and mobility to millions worldwide.
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A new "solder" for laser welding of tissue during surgical operations has the potential to produce stronger seals and expand use of this alternative to conventional sutures and stapling in intestinal surgery, scientists are reporting. Their study, which involves use of a gold-based solder, or sealing material, appears in the journal ACS Nano.
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Over 20 million people in Europe suffer from osteoarthritis which can lead to extensive damage to the knee and hip cartilage. Stem cells offer a promising way forward but a key challenge has been to design a 'smart material' that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibres such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer
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A team of researchers led by a Boston University Biomedical Engineer has developed a new joint lubricant that could bring longer lasting relief to millions of osteoarthritis sufferers.
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EntreMed, Inc., a clinical-stage pharmaceutical company developing therapeutics for the treatment of a variety of cancers, announced the issuance of a U.S. patent covering methods of treatment and formulations for its clinical-stage compound, 2-methoxyestradiol.
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Researchers at New York University and NYU Langone Medical Center have created a novel way to enhance MRI by reducing interference from large macromolecules that can often obscure images generated by current chemical exchange saturation transfer methods.
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An upcoming symposium will offer highlights of the 150-year history of Hospital for Special Surgery and at the same time provide a fascinating look at the evolution of medicine from the "Dark Ages" of the Civil War period to modern medicine as we know it today.
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Ampio Pharmaceuticals, Inc. today announced the completion of patient enrollment in a dose-escalation run-in study to a Phase III pivotal trial evaluating Ampion in the treatment of moderate to severe osteoarthritis of the knee.
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Researchers have married two biological imaging technologies, creating a new way to learn how good cells go bad. "Let's say you have a large population of cells," said Corey Neu, an assistant professor in Purdue University's Weldon School of Biomedical Engineering.
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Researchers at Micro Orthopaedics, Zhongnan Hospital of Wuhan University, led by Dr. Ai-xi Yu, have suggested that articular cartilage defects can be repaired by a novel thermo-sensitive injectable hydrogel engineered with gene modified bone marrow mesenchymal stromal cells.
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Rheumatoid arthritis (RA) is an autoimmune disorder that can cause debilitating joint damage. In cases of RA, the immune system attacks the body’s own tissues, especially the membranes that line the joints. As a result, fluid builds up in the joints, causing pain and systemic inflammation, leading to joint destruction if untreated.
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Young athletes who specialize in one sport and train intensively have a significantly higher risk of stress fractures and other severe overuse injuries, even when compared with other injured athletes, according to the largest clinical study of its kind.
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A researcher at The Feinstein Institute for Medical Research has discovered additional mechanical properties of articular cartilage, a protective cartilage on the ends of bones that wears down over time, resulting in the development of osteoarthritis.
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Hospital for Special Surgery, the nation's top hospital for orthopedics, will host Current Concepts in Sports Medicine, an educational symposium to discuss how to identify, prevent and treat articular cartilage and hip/pelvis injuries, as well as injuries common to the throwing and multisport athlete.
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Osteoarthritis, which affects at least 20 percent of adults in the United States, leads to deterioration of cartilage, the rubbery tissue that prevents bones from rubbing together.
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Platelet-rich plasma derived from blood contains growth factors and other bioactive molecules that promote healing at sites of tissue injury. However, it is difficult to deliver and retain these molecules at a target site, and clinical results have proven to be mixed - until now.
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