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Cartilage is a stiff yet flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs.
Highlights from the August issue of Mayo Clinic Health Letter

Highlights from the August issue of Mayo Clinic Health Letter

Here are highlights from the August issue of Mayo Clinic Health Letter. You may cite this publication as often as you wish. Reprinting is allowed for a fee. Mayo Clinic Health Letter attribution is required. [More]
New mechanism of joint destruction grinds away healthy cartilage, worsens osteoarthritis

New mechanism of joint destruction grinds away healthy cartilage, worsens osteoarthritis

A new mechanism of joint destruction caused by a natural material that grinds away healthy cartilage and worsens osteoarthritis has been identified in human hip joints for the first time by University of Liverpool scientists. [More]
Novel therapy takes rheumatoid arthritis treatment in mice to a new level

Novel therapy takes rheumatoid arthritis treatment in mice to a new level

Rheumatoid arthritis is a condition that causes painful inflammation of several joints in the body. The joint capsule becomes swollen, and the disease can also destroy cartilage and bone as it progresses. Rheumatoid arthritis affects 0.5% to 1% of the world's population. Up to this point, doctors have used various drugs to slow or stop the progression of the disease. [More]
Researchers postulate similarities between changes in cells and origins of triple negative breast cancer

Researchers postulate similarities between changes in cells and origins of triple negative breast cancer

Healthy breast cells may be able to reinvent themselves -- some have the flexibility to change after they are mature -- which leads researchers to postulate that similarities exist between this occurrence and the origins of a particularly aggressive type of breast cancer. [More]
AlloSource receives wellness awards from Cigna and Denver Business Journal

AlloSource receives wellness awards from Cigna and Denver Business Journal

AlloSource, one of the nation's largest providers of skin, bone and soft tissue allografts for use in surgical procedures, and the world's largest processor of cellular bone allografts, received a pair of wellness awards from Cigna and the Denver Business Journal. [More]
Protein once seen as promising anti-cancer compound helps to stabilize neural circuits

Protein once seen as promising anti-cancer compound helps to stabilize neural circuits

Researchers at UC San Francisco (UCSF) have discovered that endostatin, a protein that once aroused intense interest as a possible cancer treatment, plays a key role in the stable functioning of the nervous system. [More]
Signaling pathway key player in formation of front-most portion of developing vertebrate embryos

Signaling pathway key player in formation of front-most portion of developing vertebrate embryos

A signaling pathway once thought to have little if any role during embryogenesis is a key player in the formation of the front-most portion of developing vertebrate embryos. [More]
Paracetamol safety and osteoarthritis: an interview with Professor David Hunter, University of Sydney

Paracetamol safety and osteoarthritis: an interview with Professor David Hunter, University of Sydney

Firstly, paracetamol has been the first-line recommended treatment for osteoarthritis pain for very many years and, secondly, it is readily available over the counter and can be bought in relatively large quantities. [More]
BRI researchers use tetramer technology to find T cells that drive rheumatoid arthritis

BRI researchers use tetramer technology to find T cells that drive rheumatoid arthritis

Researchers at Benaroya Research Institute at Virginia Mason used cutting-edge tetramer technology developed at BRI to find the T cells that drive rheumatoid arthritis (RA). "By using tetramer technology, we were able to examine whether T cells in people with rheumatoid arthritis were increased in number or were unique in other ways," says BRI Associate Director Jane Buckner, MD, who led the study with BRI Tetramer Core Laboratory Manager Eddie James, PhD. [More]
Intake of monounsaturated fatty acids, cholesterol influence disease activity in RA and OA respectively

Intake of monounsaturated fatty acids, cholesterol influence disease activity in RA and OA respectively

Two new studies presented today at the European League Against Rheumatism Annual Congress have helped clarify the relationship between the dietary intake of monounsaturated fatty acids and cholesterol with disease activity in rheumatoid arthritis (RA) and osteoarthritis (OA) respectively. [More]
Grain legume crops overlooked as potentially valuable sources of micronutrients

Grain legume crops overlooked as potentially valuable sources of micronutrients

Popular diets across the world typically focus on the right balance of essential components like protein, fat, and carbohydrates. These items are called macronutrients, and we consume them in relatively large quantities. [More]
Scientist unlocks potential of stem cells for repairing neural damage to brain

Scientist unlocks potential of stem cells for repairing neural damage to brain

A QUT scientist is hoping to unlock the potential of stem cells as a way of repairing neural damage to the brain. [More]
Tissue-engineered medical devices: an interview with Anna Wynn, Business Development Manager, Instron

Tissue-engineered medical devices: an interview with Anna Wynn, Business Development Manager, Instron

Tissue Engineering and Regenerative Medicine (TERM) are dedicated to creating new tissue-engineered medical devices that replace and/or enhance tissue function that has been impaired by disease, injury, or age. [More]
Ultrasound beam 'tweezers' can grip and manipulate tiny clusters of cells

Ultrasound beam 'tweezers' can grip and manipulate tiny clusters of cells

Pioneering 'tweezers' that use ultrasound beams to grip and manipulate tiny clusters of cells under electronic, push-button control could lead to life-changing medical advances, such as better cartilage implants that reduce the need for knee replacement operations. [More]
Two new Manchester research centres aim at improving lives of people with arthritis

Two new Manchester research centres aim at improving lives of people with arthritis

Two major new research centres at The University of Manchester aimed at improving the lives of people with arthritis are to be officially launched on May 19. [More]
Regular grape consumption may help alleviate pain linked with symptomatic osteoarthritis of knee

Regular grape consumption may help alleviate pain linked with symptomatic osteoarthritis of knee

New research presented last week at the Experimental Biology conference in San Diego, California, suggests that regular grape consumption may help alleviate pain associated with symptomatic osteoarthritis of the knee, and improve joint flexibility and overall mobility. [More]
Researchers identify novel proceed to treat brittle bone disease

Researchers identify novel proceed to treat brittle bone disease

Researchers at Baylor College of Medicine have identified a new approach to treating brittle bone disease, a congenital disorder that results in fragile bones that break easily. [More]
Scientists find key information that may lead to new therapeutic approaches to epilepsy

Scientists find key information that may lead to new therapeutic approaches to epilepsy

A team of researchers from Sanford-Burnham Medical Research Institute (Sanford-Burnham) and SUNY Downstate Medical Center (SUNY Downstate) has found that deficiencies in hyaluronan, also known as hyaluronic acid or HA, can lead to spontaneous epileptic seizures. [More]
P4 pain scale found suitable for use in knee osteoarthritis

P4 pain scale found suitable for use in knee osteoarthritis

The P4 pain scale compares favorably with other commonly used measures for patients with severe knee osteoarthritis, a Canadian study has found. [More]
Sprifermin reduces cartilage loss in patients with knee osteoarthritis

Sprifermin reduces cartilage loss in patients with knee osteoarthritis

In a new study in patients with osteoarthritis (OA) of the knee, at 12 months, total femorotibial cartilage thickness loss was reduced in sprifermin (recombinant human fibroblast growth factor 18)-treated knees compared to placebo-treated knees, with effects being significant in the lateral femorotibial compartment but not in the central femorotibial compartment. [More]