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Synthetic tissue environment enables spatial definition of cancer cells and macrophages

Synthetic tissue environment enables spatial definition of cancer cells and macrophages

Tumors are notoriously difficult to study in their natural habitat - body tissues - but a new synthetic tissue environment may give cancer researchers the next-best look at tumor growth and behavior. [More]
Biocompatible scaffold enables beating heart cells to snap together like Velcro

Biocompatible scaffold enables beating heart cells to snap together like Velcro

Engineers at the University of Toronto just made assembling functional heart tissue as easy as fastening your shoes. The team has created a biocompatible scaffold that allows sheets of beating heart cells to snap together just like Velcro™. [More]
Novel chemical virus can cross double lipid layer surrounding cells to release drugs

Novel chemical virus can cross double lipid layer surrounding cells to release drugs

Viruses are able to redirect the functioning of cells in order to infect them. Inspired by their mode of action, scientists from the CNRS and Université de Strasbourg have designed a "chemical virus" that can cross the double lipid layer that surrounds cells, and then disintegrate in the intracellular medium in order to release active compounds. [More]
Keratin 17 protein plays crucial role in degrading key tumor suppressor protein

Keratin 17 protein plays crucial role in degrading key tumor suppressor protein

Keratin 17 (K17), a protein previously believed to provide only mechanical support for cancer cells, appears to play a crucial role in degrading a key tumor suppressor protein in cancer cells named p27. This finding, published in the September 1 issue of Cancer Research, is based on the work of researchers in the Department of Pathology at Stony Brook University School of Medicine. [More]
Fetal microchimerism could be a subtle and dizzyingly complex puzzle

Fetal microchimerism could be a subtle and dizzyingly complex puzzle

Parents go to great lengths to ensure the health and well-being of their developing offspring. The favor, however, may not always be returned. [More]
KAIST scientists predict how biological circuits sustain rhythms

KAIST scientists predict how biological circuits sustain rhythms

Our bodies have a variety of biological clocks that follow rhythms or oscillations with periods ranging from seconds to days. For example, our hearts beat every second, and cells divide periodically. The circadian clock located in the hypothalamus generates twenty-four hour rhythms, timing our sleep and hormone release. [More]
New non-invasive image processing technique may improve IVF success rates

New non-invasive image processing technique may improve IVF success rates

A collaboration between biologists and engineers at Monash University has led to the development of a new non-invasive image processing technique to visualise embryo formation. Researchers were able to see, for the first time, the movement of all of the cells in living mammalian embryos as they develop under the microscope. [More]
Four UC San Diego researchers selected to receive newly established NCI Outstanding Investigator Award

Four UC San Diego researchers selected to receive newly established NCI Outstanding Investigator Award

Four University of California, San Diego School of Medicine researchers have been selected to receive the newly established National Cancer Institute (NCI) Outstanding Investigator Award. The multi-million dollar awards fund new projects that have an unusual potential in cancer research over seven years. [More]
Fish oil diet modifies gut bacteria to boost health

Fish oil diet modifies gut bacteria to boost health

Diets rich in fish oil versus diets rich in lard produce very different bacteria in the guts of mice, reports a study from Sahlgrenska Academy published in Cell Metabolism. The researchers transferred these microbes into other mice to see how they affected health. The results suggest that gut bacteria share some of the responsibility for the beneficial effects of fish oil and the harmful effects of lard. [More]
Telesta Therapeutics receives FDA BLA Filing Notification for MCNA

Telesta Therapeutics receives FDA BLA Filing Notification for MCNA

Telesta Therapeutics Inc. announced today that it has received its BLA Filing Notification for MCNA from the U.S. Food and Drug Administration. This formal letter communicates that the FDA has completed its initial review of Telesta's Biologics License Application (BLA) submitted on June 29, 2015 and has accepted it for filing. [More]
Passport Health participates in clinical study to test effects of oral typhoid vaccination

Passport Health participates in clinical study to test effects of oral typhoid vaccination

Passport Health, in partnership with vaccine manufacturer PaxVax, Inc. is participating in a clinical study to test the effects of the oral typhoid vaccination, Vivotif (Typhoid Vaccine Live Oral Ty21a). The study will look at the side effects that could occur when taking Vivotif across the range of approved potencies. [More]
Cholinergic neurons in basal forebrain broadcast message throughout the cerebral cortex

Cholinergic neurons in basal forebrain broadcast message throughout the cerebral cortex

When a large combat unit, widely dispersed in dense jungle, goes to battle, no single soldier knows precisely how his actions are affecting the unit's success or failure. But in modern armies, every soldier is connected via an audio link that can instantly receive broadcasts - reporting both positive and negative surprises - based on new intelligence. The real-time broadcasts enable dispersed troops to learn from these reports and can be critical since no solider has an overview of the entire unit's situation. [More]

Scientists reveal role of dynamin and show how specific mutations impair function of dynamin

Cells continually form membrane vesicles that are released into the cell. If this vital process is disturbed, nerve cells, for example, cannot communicate with each other. The protein molecule dynamin is essential for the regulated formation and release of many vesicles. [More]
Multiple IV administration of adipose-derived MSCs may extend healthy life and lifespan

Multiple IV administration of adipose-derived MSCs may extend healthy life and lifespan

Researchers in Korea have determined the possibility that adult mesenchymal stem cells (MSCs) may extend healthy life and lifespan by intravenous injections. [More]
Findings reveal a new way to prevent meningitis

Findings reveal a new way to prevent meningitis

The fungus Cryptococcus causes meningitis, a brain disease that kills about 1 million people each year — mainly those with impaired immune systems due to AIDS, cancer treatment or an organ transplant. [More]
Powerful explosive devices of 21st century warfare prompt urgent calls to re-engineer protective gear

Powerful explosive devices of 21st century warfare prompt urgent calls to re-engineer protective gear

Battle-inflicted head injuries are as old as war itself, evidenced by the copper helmets worn by Bronze Age soldiers to deflect blows from spears and axes. Over the ensuing millennia, as weapons evolved, so did armor. Today, the powerful explosive devices of 21st century warfare have once again raised the stakes, prompting urgent calls to re-engineer protective gear. [More]
Cell-to-cell transmission of HIV leads to development of AIDS

Cell-to-cell transmission of HIV leads to development of AIDS

Researchers from the Gladstone Institutes have revealed that HIV does not cause AIDS by the virus's direct effect on the host's immune cells, but rather through the cells' lethal influence on one another. [More]
UVA researchers reveal how sperm use 'harpoon' to facilitate fertilization

UVA researchers reveal how sperm use 'harpoon' to facilitate fertilization

Could the sperm harpoon the egg to facilitate fertilization? That's the intriguing possibility raised by the University of Virginia School of Medicine's discovery that a protein within the head of the sperm forms spiky filaments, suggesting that these tiny filaments may lash together the sperm and its target. [More]
Scientists uncover mechanism responsible for development of adrenal gland tumors

Scientists uncover mechanism responsible for development of adrenal gland tumors

Scientists at the Helmholtz Zentrum München have elucidated a mechanism that is responsible for the development of adrenal gland tumors. They discovered that the BMP7 protein plays a key role in this process and that it could be a possible target for future treatments. The results have been published in the journal 'Oncotarget'. [More]
Researchers identify drugs that may enhance ability of TKI dasatinib to kill human cancer cells

Researchers identify drugs that may enhance ability of TKI dasatinib to kill human cancer cells

Researchers have discovered how a common mutation in a high-risk leukemia subtype drives the cancer's aggressiveness and have identified drugs that may work with existing precision medicines to improve survival. St. Jude Children's Research Hospital scientists led the study, which was published online today in the journal Cancer Cell. [More]
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