Cell Cycle News and Research

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Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

13 Jun 2023

Study reveals intricate pathway that dictates the cell’s ability to be resilient and plastic

Researchers have long thought that once a cell starts down its path of differentiation, growing into a skin cell or a liver cell or a neuron, that path could not be changed.

7 Jun 2023

Researchers discover sex-specific genes, molecular pathways that contribute to Alzheimer's disease progression

Alzheimer's Disease (AD) is a complex neurodegenerative illness with genetic and environmental origins.

19 May 2023

Mutation in a ribosomal protein leads to impaired cardiac contractility in mice

A team of researchers have discovered that a mutation in a ribosomal protein found specifically in heart and skeletal muscle leads to impaired cardiac contractility in mice.

19 May 2023

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

Identifying the underlying mechanism associated with the initiation of focal amplification in breast cancer.

19 May 2023

Machine learning reveals sex-specific Alzheimer's risk genes

Research explores sex-specific gene associations in Alzheimer's disease using a machine-learning approach. It reveals immune response pathways in both sexes and stress-response pathways in males, highlighting potential biomarkers and therapeutic targets for personalized treatments.

16 May 2023

Finnish mitochondrial disease of newborns shows cancer-like changes in proliferating cells

A study found that a mitochondrial disease of newborns shows cancer-like changes in proliferating cells, causing tissues to age prematurely.

3 May 2023

Drugs targeting FXR1 may treat vascular proliferative diseases

Vascular diseases, including myocardial infarction, stroke, renal failure, and peripheral vascular disease, continue to account for one third of all mortality in the United States, Europe, and the developing world (World Health Organization, 2021).

2 May 2023

Novel chronic murine wound mouse model to study cellular senescence

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "A chronic wound model to investigate skin cellular senescence."

2 May 2023

Study evaluates the effects of phenolic compounds in extra virgin olive oil on skin health

Researchers evaluated the effects of phenolic compounds in extra virgin olive oil on human fibroblasts.

27 Apr 2023

Study reveals ERK signaling as a crucial molecular switch between scarring and regeneration

Why do some animals regenerate lost tissues after injury while others don't? Researchers from the lab of Kerstin Bartscherer (Osnabrück University and formerly Hubrecht Institute) and Ashley Seifert (University of Kentucky) studied spiny mice, which have a remarkable regenerative capacity, to answer this question.

26 Apr 2023

New study aims to elucidate the role of p21 in chronic lung inflammation

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 7, entitled, "p21 facilitates chronic lung inflammation via epithelial and endothelial cells."

18 Apr 2023

Bonn researchers elucidate a mechanism underlying cisplatin resistance in testicular cancer

Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options.

11 Apr 2023

Scientists develop genetically defined mouse models for multiple myeloma subtypes

A team of scientists led by Martin Janz and Klaus Rajewsky at the Max Delbrück Center has successfully generated genetically defined mouse models for two subtypes of multiple myeloma.

16 Mar 2023

Different cellular building blocks are not produced at the same time, research shows

Textbooks will tell you that in dividing cells, the production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level.

27 Feb 2023

A new trial to assess if butyrate can prevent colon cancer

Researchers discuss a new clinical trial that will determine the efficacy of butyrate administration in preventing colon cancer.

16 Feb 2023

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Researchers evaluated the clinical and genetic characteristics of acute myeloid leukemia (AML) patients with a mutant Ikaros zinc finger protein 1 (IKZF1).

2 Feb 2023

UT Southwestern physician-scientist wins NIH award to support heart regeneration research

UT Southwestern physician-scientist Hesham Sadek, M.D., Ph.D., has received the prestigious National Institutes of Health Outstanding Investigator Award to support his ongoing research into mechanisms behind heart regeneration that could lead to treatments for heart failure.

30 Jan 2023

New candidate molecule could become an effective non-hormonal male contraceptive

Despite birth control existing for decades, almost none of the options specifically target sperm cells. Researchers are now developing approaches that target testosterone or otherwise interrupt the sperm's ability to fertilize an egg, yet these may not work for everyone.

30 Jan 2023

Researchers discover a key role played by ch-TOG protein in the initiation of microtubule assembly

Microtubules are cellular fibres that are part of the skeleton of the cell, termed cytoskeleton. They ensure that cells maintain their shape, carry out their functions, and divide.

27 Jan 2023

Cell Cycle News and Research

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

Study reveals intricate pathway that dictates the cell’s ability to be resilient and plastic

Researchers discover sex-specific genes, molecular pathways that contribute to Alzheimer's disease progression

Mutation in a ribosomal protein leads to impaired cardiac contractility in mice

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

Machine learning reveals sex-specific Alzheimer's risk genes

Finnish mitochondrial disease of newborns shows cancer-like changes in proliferating cells

Drugs targeting FXR1 may treat vascular proliferative diseases

Novel chronic murine wound mouse model to study cellular senescence

Study evaluates the effects of phenolic compounds in extra virgin olive oil on skin health

Study reveals ERK signaling as a crucial molecular switch between scarring and regeneration

New study aims to elucidate the role of p21 in chronic lung inflammation

Bonn researchers elucidate a mechanism underlying cisplatin resistance in testicular cancer

Scientists develop genetically defined mouse models for multiple myeloma subtypes

Different cellular building blocks are not produced at the same time, research shows

A new trial to assess if butyrate can prevent colon cancer

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

UT Southwestern physician-scientist wins NIH award to support heart regeneration research

New candidate molecule could become an effective non-hormonal male contraceptive

Researchers discover a key role played by ch-TOG protein in the initiation of microtubule assembly

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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